这个基因属于R-海绵蛋白家族。编码蛋白在Wnt（wingless-type-MMTV-integration-site-family）/beta-catenin和Wnt/平面细胞极性（planar cell polarity，PCP）信号通路的调控中发挥作用，参与发育、细胞生长和疾病的发生全基因组相关研究表明该基因与骨密度和骨折风险相关。该基因可能参与肿瘤的发生发展[由RefSeq提供，2013年7月]
This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]