国自然科学基金委：通报这10项科研不端案件处理决定

　　国家自然科学基金委员会坚决贯彻落实中共中央办公厅、国务院办公厅《关于进一步加强科研诚信建设的若干意见》《关于进一步弘扬科学家精神加强作风和学风建设的意见》精神，为净化学术生态，保障高水平科技自立自强，持续深入开展科研诚信建设，对涉及国家自然科学基金的科研不端行为进行严肃查处。国家自然科学基金委员会监督委员会对受理的科研诚信案件开展调查核实、综合研判，依照《国家自然科学基金条例》《国家自然科学基金委员会监督委员会对科学基金资助工作中不端行为的处理办法（试行）》《国家自然科学基金项目科研不端行为调查处理办法》等法规制度提出处理建议。国家自然科学基金委员会2022年度第2次委务会议经审议，决定对相关涉事主体进行处理。现将其中给予通报批评的10份处理决定（网络发布版）予以公布。

关于对吴冬梅、郑元林、陆军等发表的论文存在图片或数据造假、编造研究过程和未经同意使用他人署名以及项目结题报告中存在虚假信息等问题的处理决定

国科金监处〔2022〕1号

　　国家自然科学基金委员会监督委员会对江苏师范大学吴冬梅、郑元林、陆军等多篇论文涉嫌学术不端开展了调查，涉事论文如下：

　　论文1：“Lu, Hong-Jie#； Yan, Jing#； Jin, Pei-Ying#； Zheng, Gui-Hong； Qin, Su-Ming； Wu, Dong-Mei*； Lu, Jun*； Zheng, Yuan-Lin*. MicroRNA-152 inhibits tumor cell growth while inducing apoptosis via the transcriptional repression of cathepsin L in gastrointestinal stromal tumor. Cancer Biomarkers, 2018, 21(3):711-722.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文2：“Dong-Mei Wu, Xin Wen, Xin-Rui Han, Shan Wang, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Jun Lu*, Yuan-Lin Zheng*, Gui-Quan Chen*. Reduced LINC00540 Expression Inhibits Human Hepatocellular Carcinoma Progression and Metastasis via the NKD2-Dependent Wnt/β-Catenin Pathway. SSRN Electronic Journal, 2019.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文3：“Xin Wen#, Jing Yan#, Xin-Rui Han#, Gui-Hong Zheng, Ran Tang, Li-Fang Liu, Dong-Mei Wu, Jun Lu*, Yuan-Lin Zheng*. PTEN gene silencing contributes to airway remodeling and induces airway smooth muscle cell proliferation in mice with allergic asthma. Journal of Thoracic Disease，2018, 10(1):202-211.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文4：“Zi-Feng Zhang#, Yong-Jian Wang#, Shao-Hua Fan, Shi-Xin Du, Xue-Dong Li, Dong-Mei Wu*, Jun Lu* and Yuan-Lin Zheng*. MicroRNA-182 downregulates Wnt/β-catenin signaling, inhibits proliferation, and promotes apoptosis in human osteosarcoma cells by targeting HOXA9.Oncotarget, 2017, 8(60):101345-101361.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文5：“Yong-Jian Wang#, Zi-Feng Zhang#, Shao-Hua Fan, Juan Zhuang, Qun Shan, Xin-Rui Han, Xin Wen, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Bin Qiao, Qian Tao, Dong-Mei Wu*, Jun Lu* and Yuan-Lin Zheng*. MicroRNA-433 inhibits oral squamous cell carcinoma cells by targeting FAK. Oncotarget, 2017, 8(59):100227-100241.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文6：“Xin-Rui Han#, Xin Wen#, Yong-Jian Wang#, Shan Wang, Min Shen, Zi-Feng Zhang, Shao-Hua Fan, Qun Shan, Liang Wang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu*, Jun Lu*and Yuan-Lin Zheng*. Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia. Molecular Medicine, 2018, 24:18.”（标注基金号81271225、81171012、30950031、81571055、81400902、81570531、81672731）

　　论文7：“Hong-Jie Lu#, Jing Yan#, Pei-Ying Jin#, Gui-Hong Zheng#, Hai-Lin Zhang#, Ming Bai#, Dong-Mei Wu*, Jun Lu*, and Yuan-Lin Zheng*. Mechanism of MicroRNA-708 Targeting BAMBI in Cell Proliferation, Migration, and Apoptosis in Mice With Melanoma via the Wnt and TGF-β Signaling Pathways. Technology in Cancer Research & Treatment, 2018, 17:1-15.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文8：“Dong-Mei Wu#, Shan Wang#, Xin Wen, Xin-Rui Han, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Jun Lu*, Yuan-Lin Zheng*. Inhibition of microRNA-200a Upregulates the Expression of Striatal Dopamine Receptor D2 to Repress Apoptosis of Striatum via the cAMP/PKA Signaling Pathway in Rats with Parkinson’s Disease. Cellular Physiology and Biochemistry, 2018, 51:1600-1615.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文9：“Dong-Mei Wu#, Xin-Rui Han#, Xin Wen#, Shan Wang, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Jun Lu*, Yuan-Lin Zheng*. Long Non-Coding RNA LINC01260 Inhibits the Proliferation, Migration and Invasion of Spinal Cord Glioma Cells by Targeting CARD11 Via the NF-κB Signaling Pathway. Cellular Physiology and Biochemistry, 2018, 48:1563-1578.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文10：“Dong-Mei Wu#, Xin-Rui Han#, Xin Wen#, Shan Wang, Shao-Hua Fan, Juan Zhuang, Yong-Jian Wang, Zi-Feng Zhang, Meng-Qiu Li, Bin Hu, Qun Shan, Chun-Hui Sun, Jun Lu*, Yuan-Lin Zheng*. Salidroside Protection Against Oxidative Stress Injury Through the Wnt/β-Catenin Signaling Pathway in Rats with Parkinson’s Disease. Cellular Physiology and Biochemistry, 2018, 46:1793-1806.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文11：“Dong-Mei Wu#, Xin Wen#, Xin-Rui Han#, Shan Wang, Yong-Jian Wang, Min Shen,Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Jun Lu*, and Yuan-Lin Zheng*. Micro-RNA-143 inhibits proliferation and promotes apoptosis of thymocytes by targeting CXCL13 in a myasthenia gravis mouse model. AJP Cell Physiology, 2019, 316:C70-C80.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文12：“Dong-Mei Wu#, Shan Wang#, Xin Wen, Xin-Rui Han, Yong-Jian Wang, Shao-Hua Fan, Zi-Feng Zhang, Qun Shan, Jun Lu*, and Yuan-Lin Zheng*. MircoRNA-1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1. Journal of Cellular and Molecular Medicine, 2018, 22:4963-4974.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文13：“Xin-Rui Han#, Xin Wen#, Yong-Jian Wang#, Shan Wang, Min Shen, Zi-Feng Zhang, Shao-Hua Fan, Qun Shan, Liang Wang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu*, Jun Lu*, Yuan-Lin Zheng*. MicroRNA-140-5p elevates cerebral protection of dexmedetomidine against hypoxic-ischaemic brain damage via the Wnt/β-cateninsignalling pathway. Journal of Cellular and Molecular Medicine, 2018, 22:3167-3182.”（标注基金号81271225、81171012、30950031、81571055、81400902、81570531、81672731）

　　论文14：“Dong-Mei Wu#, Yong-Jian Wang#, Xin-Rui Han, Xin Wen, Lei Li, Lan Xu, Jun Lu*, Yuan-Lin Zheng*. Tanshinone IIA prevents left ventricular remodelling via the TLR4/MyD88/NF-κBsignalling pathway in rats with myocardial infarction. Journal of Cellular and Molecular Medicine, 2018, 22:3058-3072.”（标注基金号81271225、81171012、30950031、81571055、81400902、81570531、81672731）

　　论文15：“Dong-Mei Wu#, Shan Wang#, Min Shen#, Yong-Jian Wang, Bo Zhang, Zi-Qi Wu, Jun Lu*, Yuan-Lin Zheng*. S100A9 gene silencing inhibits the release of pro-inflammatory cytokines by blocking the IL-17 signalling pathway in mice with acute pancreatitis. Journal of Cellular and Molecular Medicine, 2018, 22:2378-2389.”（标注基金号81271225、81171012、30950031、81571055、81400902、81570531、81672731）

　　论文16：“Shan Wang#, Xin Wen#, Xin-Rui Han, Yong-Jian Wang,Min Shen, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan,Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu*, Jun Lu*, Yuan-Lin Zheng*. Repression of microRNA-382 inhibits glomerular mesangial cell proliferation and extracellular matrix accumulation via FoxO1 in mice with diabetic nephropathy. Cell Proliferation, 2018, e12462.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文17：“Yao Tang#, Qi-Hang Cai#, Yong-Jian Wang, Shao-Hua Fan, Zi-Feng Zhang, Meng-Qi Xiao, Jin-Yu Zhu, Dong-Mei Wu*, Jun Lu* and Yuan-Lin Zheng*. Protective effect of autophagy on endoplasmic reticulum stress induced apoptosis of alveolar epithelial cells in rat models of COPD. Bioscience Report, 2017, 37(6).”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文18：“Xin Wen#, Xin-Rui Han#, Shao-Hua Fan, Zi-Feng Zhang, Lu Chen, Gao Yi, Dong-Mei Wu*, Jun Lu* and Yuan-Lin Zheng*. Down-regulation of XIAP enhances the radiosensitivity of esophageal cancer cells in vivo and in vitro. Bioscience Report, 2017, 37(5).”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文19：“Hong-Jie Lu#, Pei-Ying Jin#, Yao Tang#, Shao-Hua Fan, Zi-Feng Zhang, Fang Wang, Dong-Mei Wu*, Jun Lu*, Yuan-Lin Zheng*. microRNA-136 inhibits proliferation and promotes apoptosis and radiosensitivity of cervical carcinoma through the NF-κB pathway by targeting E2F1. Life Sciences, 2018, 199:167-178.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文20：“Yong-Jian Wang#, Min Shen#, Shan Wang#, Xin Wen, Xin-Rui Han, Zi-Feng Zhang, Hui Li, Fei Wang, Dong-Mei Wu*, Jun Lu*, Yuan-Lin Zheng*. Inhibition of the TGF-β1/Smad signaling pathway protects against cartilage injury and osteoarthritis in a rat model. Life Sciences, 2017, 189:106-113.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文21：“Xiao-Fei Jin#, Shan Wang#, Min Shen#, Xin Wen, Xin-Rui Han, Jun-Chang Wu, Gao-Zhuo Tang, Dong-Mei Wu*, Jun Lu*, Yuan-Lin Zheng*. Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways. Brain Research Bulletin, 2017, 134:236-245.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文22：“Pei-Ying Jin#, Hong-Jie Lu#, Yao Tang#, Shao-Hua Fan, Zi-Feng Zhang, Yan Wang, Xu-Ning Li, Dong-Mei Wu*, Jun Lu*, Yuan-Lin Zheng*. The effect of DNA-PKcs gene silencing on proliferation, migration, invasion and apoptosis, and in vivo tumorigenicity of human osteosarcoma MG-63 cells. Biomedicine & Pharmacotherapy, 2017, 96:1324-1334.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文23：“Qi-Hang Cai#, Yao Tang#, Shao-Hua Fan, Zi-Feng Zhang, Hong Li, Shao-Qiang Huang, Dong-Mei Wu*, Jun Lu*, Yuan-Lin Zheng*. In vivo effects of dexmedetomidine on immune function and tumor growth in rats with ovarian cancer through inhibiting the p38MAPK/NF-κB signaling pathway. Biomedicine & Pharmacotherapy, 2017, 95:1830-1837.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文24：“Min Shen#, Shan Wang#, Xin Wen, Xin-Rui Han, Yong-Jian Wang, Xiu-Min Zhou, Man-He Zhang, Dong-Mei Wu*, Jun Lu*, Yuan-Lin Zheng*. Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K/Akt/mTOR signaling pathway in rats with traumatic brain injury. Biomedicine & Pharmacotherapy, 2017, 95(3):885-893.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文25：“Dong-Mei Wu#, Shan Wang#, Xin Wen, Xin-Rui Han, Yong-Jian Wang, Shao-Hua Fan, Zi-Feng Zhang, Qun Shan, Jun Lu*, Yuan-Lin Zheng*. Long noncoding RNA nuclear enriched abundant transcript 1 impacts cell proliferation, invasion, and migration of glioma through regulating miR-139-5p/CDK6. Journal of Cellular Biochemistry, 2019, 234(5):5972-5987.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文26：“Dong-Mei Wu#, Xin Wen#, Yong-Jian Wang, Xin-Rui Han, Shan Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Jun Lu*, Gui-Quan Chen*, Yuan-Lin Zheng*. Effect of microRNA-186 on oxidative stress injury of neuron by targeting interleukin 2 through the janus kinase-signal transducer and activator of transcription pathway in a rat model of Alzheimer’s disease. Journal of Cellular Biochemistry, 2018, 233(12):9488-9502.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文27：“Shan Wang#, Xin Wen#, Xin-Rui Han#, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Wei Xu, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu*, Jun Lu*, Yuan-Lin Zheng*. MicroRNA-30d preserves pancreatic islet β-cell function through negative regulation of the JNK signaling pathway via SOCS3 in mice with streptozotocin-induced diabetes mellitus. Journal of Cellular Biochemistry, 2018, 233(9):7343-7355.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文28：“Xin Wen#, Xin-Rui Han#, Yong-Jian Wang#, Shan Wang, Min Shen, Zi-Feng Zhang, Shao-Hua Fan, Qun Shan, Liang Wang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu*, Jun Lu*, Yuan-Lin Zheng*. MicroRNA-421 suppresses the apoptosis and autophagy of hippocampal neurons in epilepsy mice model by inhibition of the TLR/MYD88 pathway. Journal of Cellular Biochemistry, 2018, 233(9):7022-7034.”（标注基金号81271225、81171012、81571055、81400902、81570531）

　　论文29：“Xin-Rui Han#, Xin Wen#, Yong-Jian Wang#, Shan Wang, Min Shen, Zi-Feng Zhang, Shao-Hua Fan, Qun Shan, Liang Wang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu*, Jun Lu*, Yuan-Lin Zheng*. Protective effects of microRNA-431 against cerebral ischemia-reperfusion injury in rats by targeting the Rho/Rho-kinase signaling pathway. Journal of Cellular Biochemistry, 2018, 233(8):5895-5907.”（标注基金号81271225、81171012、30950031、81571055、81400902、81570531、81672731）

　　论文30：“Dong-Mei Wu#, Yong-Jian Wang#, Xin-Rui Han, Xin Wen, Shan Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Jun Lu*, Yuan-Lin Zheng*. LncRNA LINC00880 promotes cell proliferation, migration, and invasion while inhibiting apoptosis by targeting CACNG5 through the MAPK signaling pathway in spinal cord ependymoma. Journal of Cellular Biochemistry, 2018, 233(9):6689-6704.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文31：“Xin Wen#, Xin-Rui Han#, Yong-Jian Wang#, Shan Wang, Min Shen, Zi-Feng Zhang, Shao-Hua Fan, Qun Shan, Liang Wang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu*, Jun Lu*, and Yuan-Lin Zheng*. Down-regulated long non-coding RNA ANRIL restores the learning and memory abilities and rescues hippocampal pyramidal neurons from apoptosis in streptozotocin-induced diabetic rats via the NF-κB signaling. Journal of Cellular Biochemistry, 2018, 119(7):5821-5833.”（标注基金号81271225、81171012、30950031、81571055、81400902、81570531、81672731）

　　论文32：“Xin Wen#, Xin-Rui Han#, Yong-Jian Wang#, Shao-Hua Fan, Zi-Feng Zhang, Dong-Mei Wu*, Jun Lu*, Yuan-Lin Zheng*. Effects of S100A12 gene silencing on serum levels of anti-inflammatory/pro-inflammatory cytokines in septic rats through the ERK signaling pathway. Journal of Cellular Biochemistry, 2018, 119(5):4038-4049.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文33：“Gui-Hong Zheng#, Xin Wen#, Yong-Jian Wang#, Xin-Rui Han#, Qun Shan, Wang Li, Tian Zhao, Dong-Mei Wu*, Jun Lu*, Yuan-Lin Zheng*. MicroRNA-381-induced down regulation of CXCR4 promotes the proliferation of renal tubular epithelial cells in rat models of renal ischemia reperfusion injury. Journal of Cellular Biochemistry, 2018, 119(4):3149-3161.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文34：“Xin Wen#, Xin-Rui Han#, Yong-Jian Wang#, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Qiao Wu, Jun-Hua Tan, Dong-Mei Wu*, Jun Lu*, Yuan-Lin Zheng*. Effects of long noncoding RNA SPRY4-IT1-mediated EZH2 on the invasion and migration of lung adenocarcinoma. Journal of Cellular Biochemistry, 2018, 119(2):1827-1840.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　论文35：“Dong-Mei Wu, Xiao-Wu Hong, Xin Wen, Xin-Rui Han, Shan Wang, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Jun Lu*, Yuan-Lin Zheng*. MCL1 gene silencing promotes senescence and apoptosis of glioma cells via inhibition of the PI3K/Akt signaling pathway. IUBMB Life, 2019, 71(1):81-92.”（标注基金号81271225、31201039、81171012、30950031、81571055、81400902）

　　经依托单位调查，上述35篇涉事论文均存在图片不当使用或数据造假的问题，存在问题的图片或数据均由第三方公司提供。35篇涉事论文中，有34篇（除论文21外）还存在未经同意使用他人署名的问题，论文4、5、9、12、30、34还存在编造研究过程的问题。吴冬梅作为上述35篇涉事论文的撰写人，其中12篇论文（论文2、8、9、10、11、12、14、15、25、26、30、35）的第一作者和22篇论文（论文1、4、5、6、7、13、16、17、18、19、20、21、22、23、24、27、28、29、31、32、33、34）的通讯作者，应对图片或数据造假的客观结果、未经同意使用他人署名和编造研究过程负主要责任；郑元林和陆军作为35篇涉事论文的共同通讯作者，疏于审核，负次要责任。此外，吴冬梅将4篇涉事论文（论文21、24、28、29）列入其国家自然科学基金项目（批准号81400902）结题报告中，郑元林将9篇涉事论文（论文6、8、10、13、21、24、26、28、29）列入其国家自然科学基金项目（批准号81571055）结题报告中，均应对在结题报告中存在虚假信息的客观结果负责。

　　经国家自然科学基金委员会监督委员会五届十二次会议（生命医学专业委员会）审议、国家自然科学基金委员会2022年第2次委务会议审定，决定依照《国家自然科学基金条例》第三十五条第四项、《国家自然科学基金委员会监督委员会对科学基金工作中不端行为的处理办法（试行）》第十七条第三、四项、第九条，撤销吴冬梅国家自然科学基金项目“TRPV4介导软骨藻酸处理致小鼠认知缺陷的分子机制”（批准号81400902），追回已拨资金，永久取消吴冬梅国家自然科学基金项目申请资格（自2022年1月18日起），给予吴冬梅通报批评；决定依照《国家自然科学基金条例》第三十五条第四项，并参照《国家自然科学基金委员会监督委员会对科学基金工作中不端行为的处理办法（试行）》第十七条第三、四项，撤销郑元林国家自然科学基金项目“HDAC6激活HMGB1/RAGE信号轴介导Ⅱ型糖尿病小鼠认知缺陷的机制研究”（批准号81571055），追回已拨资金，取消郑元林国家自然科学基金项目申请资格5年（2022年1月18日至2027年1月17日），给予郑元林通报批评；决定参照《国家自然科学基金委员会监督委员会对科学基金工作中不端行为的处理办法（试行）》第十七条第三、四项，取消陆军国家自然科学基金项目申请资格5年（2022年1月18日至2027年1月17日），给予陆军通报批评。

　　国家自然科学基金委员会

　　2022年3月30日

关于对汤华等发表的论文存在图片不当操作及实验数据混乱以及项目申请书、进展报告及结题报告中存在虚假信息等问题的处理决定

国科金监处〔2022〕2号

　　国家自然科学基金委员会监督委员会对天津医科大学汤华等发表的论文涉嫌学术不端开展了调查，涉事论文如下：

　　论文1: “Yaqi Hu#, Xu Guo#, Jinxia Wang#, Yankun Liu, Huijie Gao, Hongxia Fan, Xiangyang Nong, Xi Yang, Min Liu, Shengping Li, Hua Tang*. A novel microRNA identified in hepatocellular carcinomas is responsive to LEF1 and facilitates proliferation and epithelial-mesenchymal transition via targeting of NFIX. Oncogenesis. 2018, 7(2):22.”（标注基金号91629302、81572790、31270818、81602410）

　　论文2: “Xi Yang, Yaqi Hu, Yankun Liu, Weiying Liu, Xiaoqing Zhao, Min Liu, Hua Tang*. C14orf28 downregulated by miR-519d contributes to oncogenicity and regulates apoptosis and EMT in colorectal cancer. Molecular and Cellular Biochemistry. 2017, 434(1-2):197-208.” (标注基金号81572790、91629302、91029714、31270818)

　　论文3: “Weiying Liu, Shixing Wang, Qi Sun, Zhen Yang, Min Liu, Hua Tang*. DCLK1 promotes epithelial-mesenchymal transition via the PI3K/Akt/NF-κB pathway in colorectal cancer. International Journal of Cancer. 2018, 142(10):2068-2079.”（标注基金号81602512、91629302、81572790、31270818、91029714）

　　论文4: “Peipei Zhang#, Xiangling Wang#, Wei Zhao#, Bing Qi, Qian Yang, Haiying Wan, Zeyu Shuang, Min Liu, Xin Li, Shengping Li*, Hua Tang*. DNA methylation-mediated repression of miR-941 enhances lysine (K)-specific demethylase 6B expression in hepatoma cells.The Journal of Biological Chemistry.2014. 289(35):24724-35.” (标注基金号31270818、91029714、31071191)

　　论文5: “Xue Liu#, Qian Liu#, Yajie Fan#, Shaohua Wang#, Xinrui Liu, Lihua Zhu, Min Liu, Hua Tang*. Downregulation of PPP2R5E expression by miR-23a suppresses apoptosis to facilitate the growth of gastric cancer cells. FEBS Letters. 2014, 588(17):3160-3169.” (标注基金号91029714、31270818、31101000)

　　论文6: “Liming Guo#, Rui Gao#, Jianchen Gan#, Yanan Zhu, Junyi Ma, Ping Lv, Yi Zhang, Shengping Li, Hua Tang*. Downregulation of TNFRSF19 and RAB43 by a novel miRNA, miR-HCC3, promotes proliferation and epithelial–mesenchymal transition in hepatocellular carcinoma cells.Biochemical and Biophysical Research Communications. 2020, 525(2):425-432.” (标注基金号81830094、91629302、81572790、31270818)

　　论文7：“Lili Yao#, Yadi Zhou#, Zhenhua Sui#, YanlingZhang, Yankun Liu, Hong Xie, Huijie Gao, Hongxia Fan, Yi Zhang, Min Liu, Shengping Li, Hua Tang*. HBV-encoded miR-2 functions as an oncogene by downregulating TRIM35 but upregulating RAN in liver cancer cells. EBioMedicine.2019, 48:117-129.” (标注基金号 81830094、91629302、31270818)

　　论文8: “Xiaoxiao Kong#, YanruLv#, Liping Shao#, Xiangyang Nong, Guangling Zhang, Yi Zhang, Hongxia Fan, Min Liu, Xin Li, Hua Tang*. HBX-induced MiR-1269b in NF-κB dependent manner upregulates cell division cycle 40 homolog (CDC40) to promote proliferation and migration in hepatoma cells. J Transl Med.2016, 14(1):189.” (标注基金号 91029714、81201281、31270818、81572790)

　　论文9: “Zheng Chen#, Xiangling Wang#, Ruiyan Liu#, Lin Chen, Jianying Yi, Bing Qi, Zeyu Shuang, Min Liu, Xin Li, Shengping Li, Hua Tang*. KDM4B-mediated epigenetic silencing of miRNA-615-5p augments RAB24 to facilitate malignancy of hepatoma cells. Oncotarget. 2017, 8(11):17712-17725.” (标注基金号31270818、91029714、81371667、81572790)

　　论文10: “Qian Liu#, Xu Guo#, Shengshun Que#, Xi Yang, Hongxia Fan, Min Liu, Xin Li, Hua Tang*. LncRNA RSU1P2 contributes to tumorigenesis by acting as a ceRNA against let-7a in cervical cancer cells. Oncotarget. 2017, 8(27):43768-43781.” (标注基金号91029714、81572790、31270818、31101000)

　　论文11: “Lifen Wu#, Chunli Cai#, Xinghua Wang#, Min Liu, Xin Li, Hua Tang*. MicroRNA-142-3p, a new regulator of RAC1, suppresses the migration and invasion of hepatocellular carcinoma cells. FEBS Letters. 2011, 585(9):1322-1330.” (标注基金号30873017、91029714、31071191)

　　论文12: “Xuemei Xu#, Xiaobo Wang#, Miaomiao Chen#, Tao Liu, Yixuan Li, Weihua Jia, Min Liu, Xin Li, Hua Tang*. MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5. Cancer Letters. 2012, 322(2):148-158.” (标注基金号30873017、91029714、31071191)

　　论文13: “Ruiqing Peng#, Haiying Wan#, Haifang Li#, Min Liu, Xin Li, Hua Tang*. MicroRNA-214 suppresses growth and invasiveness of cervical cancer cells by targeting UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7. The Journal of Biological Chemistry. 2012, 287(17): 14301–14309.” (标注基金号30873017、91029714、31071191)

　　论文14: “Jinghua Wang#, Le Zhang#, Yuwei Ma#, Jing Xiao, Yi Zhang, Min Liu, Hua Tang*. MicroRNA-34a-upregulated retinoic acid-inducible gene-I promotes apoptosis and delays cell cycle transition in cervical cancer cells DNA and cell biology. 2016, 35(6): 267-279.” (标注基金号 31301132、91029714、31270818、31071191)

　　论文15：“Lan Li#, Li He#, Jianli Zhao#, Jing Xiao, Min Liu, Xin Li, Hua Tang*. MiR-17-5p up-regulates YES1 to modulate the cell cycle progression and apoptosis in ovarian cancer cell lines. J Cell Biochem. 2015, 116(6):1050-9.”（标注基金号31270818、91029714、31071191）

　　论文16：“Jianli Zhao#, Le Zhang#, Xu Guo#, Jinghua Wang, Wen Zhou, Min Liu, Xin Li, Hua Tang*. miR-212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymaltransition in cervical cancer cells. IUBMB Life. 2015, 67(5):380-94.”（标注基金号31270818、91029714、31071191、31101000、81201281）

　　论文17：“Jing Ru#, Huahui Sun#, Hongxia Fan#, Chunmei Wang, Yixuan Li, Min Liu, Hua Tang*. MiR-23a Facilitates the Replication of HSV-1 through the Suppression of Interferon Regulatory Factor 1.Plos One. 2014, 9(12):e114021.”（标注基金号31100933、31270818、91029714、31071191、81201281）

　　论文18：“Zhen Yang#, Xiangling Wang#, Ru Bai#, Weiying Liu, Xin Li, Min Liu, Hua Tang*. miR-23a promotes IKKα expression but suppresses ST7L expression to contribute to the malignancy of epithelial ovarian cancer cells. British Journal of Cancer. 2016, 115:731–740.”（标注基金号91029714、31270818、81572790）

　　论文19：“Xue Liu#, Jing Ru#, Jian Zhang#, Lihua Zhu, Min Liu, Xin Li, Hua Tang*. miR-23a Targets Interferon Regulatory Factor 1 and Modulates Cellular Proliferation and Paclitaxel-Induced Apoptosis in Gastric Adenocarcinoma Cells. Plos One. 2013, 8(6): e64707.”（标注基金号31270818、91029714、31071191）

　　论文20：“Mingxue Zhang#, Jie Zhang#, Hong Zhang*, Hua Tang*. miR-24-3p suppresses malignant behavior of lacrimal adenoid cystic carcinoma by targeting prkch to regulate p53/p21 pathway. Plos One, 2016, 11 (6):e0158433.”（标注基金号91029714、31270818、81572790）

　　论文21：“Hua Li#, Hui Song#, Xiaoyong Yuan, Jun Li, Hua Tang*. miR-30a reverses TGF-β2-induced migration and EMT in posterior capsular opacification by targeting Smad2. Mol Biol Rep. 2019, 46(4):3899-3907.” （标注基金号91629302、81572790）

　　论文22：“Junfei Guo, Jing Lv, Min Liu, Hua Tang*. miR-346 up-regulates argonaute 2 (ago2) protein expression to augment the activity of other microRNAs (miRNAs) and contributes to cervical cancer cell malignancy. J Biol Chem. 2015, 290(51): 30342–30350.” （标注基金号31270818、91029714、31071191）

　　论文23：“Weiying Liu, Zhen Yang, Qi Sun, Xi Yang, Yang Hu, Hong Xie, Huijie Gao, Liming Guo, Jianying Yi, Min Liu, Hua Tang*. miR-377-3p drives malignancy characteristics via upregulating GSK-3β expression and activating NF-κB pathway in hCRC cells. Journal of Cellular Biochemistry. 2018, 119(2):2124-2134.”（标注基金号81602512、91629302、81572790、31270818、91029714）

　　论文24：“Yang Hu, Hong Xie, Yankun Liu, Weiying Liu, Min Liu, Hua Tang*. miR-484 suppresses proliferation and epithelial -mesenchymal transition by targeting of ZEB1 and SMAD2 in cervical cancer cells. Cancer Cell International. 2017,17(1): 36.”（标注基金号91029714、31270818、81572790）

　　论文25：“Lingyun Zhang, Min Liu*, Xin Li, Hua Tang*. miR-490-3p modulates cell growth and epithelial to mesenchymal transition of hepatocellular carcinoma cells by targeting endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3). J Biol Chem. 2013, 288(6):4035–4047.”（标注基金号31270818、91029714、31071191）

　　论文26：“Jing Xiao#, Yankun Liu#, Fuxia Wu#, Ruiyan Liu#, YongliXie, Qian Yang, Yufeng Li, Min Liu, Shengping Li, Hua Tang*. miR-639 expression is silenced by dnmt3a-mediated hypermethylation and functions as a tumor suppressor in liver cancer cells. Molecular Therapy. 2020, 28(2):587-598.”（标注基金号81830094、81572790、91629302、81573115）

　　论文27：“Jian Zhang#, Haidong Wu#, Pu Li#, Yanzheng Zhao, Min Liu, Hua Tang*. NF-κB-modulated miR-130a targets TNF-α in cervical cancer cells. Journal of Translational Medicine. 2014, 12:155.”（标注基金号31270818、91029714、31071191、31101000）

　　论文28：“Chang Su#, Zhongjie Ren#, Fang Wang, Min Liu, Xin Li, Hua Tang*. PIWIL4 regulates cervical cancer cell line growth and is involved in down-regulating the expression of p14ARF and p53. FEBS Letters. 2012, 586:1356–1362.”（标注基金号91029714、31071191）

　　论文29：“Ying Zhu#, Yan Zhang#, Zhenhua Sui, Yi Zhang, Min Liu, Hua Tang*. USP14 de-ubiquitinates vimentin and miR-320a modulates USP14 and vimentin to contribute to malignancy in gastric cancer cells. Oncotarget. 2017,8(30):48725-48736.”（标注基金号91029714； 31270818: 81572790）

　　论文30：“Chaoqun Ma#, Ying Qi#, Liping Shao#, Min Liu, Xin Li, Hua Tang*. Downregulation of miR-7 upregulates Cullin 5 (CUL5) to facilitate G1/S transition in human hepatocellular carcinoma cells. IUBMB Life, 2013. 65(12): 1026-34.”（标注基金号91029714、31071191、31270818）

　　论文31：“Qi Sun#, Zhen Yang#, Pu Li#, Xu Wang, Lu Sun, Shixing Wang, Min Liu, Hua Tang*. A novel miRNA identified in GRSF1 complex drives the metastasis via the PIK3R3/AKT/NF-κB and TIMP3/MMP9 pathways in cervical cancer cells. Cell Death and Disease.2019,10:636.”（标注基金号91629302、81572790、81830094、31270818）

　　论文32：“Yankun Liu, Yingnan Zhang, Haidong Wu, Yufeng Li, Yi Zhang, Min Liu, Xin Li, Hua Tang*. miR-10a suppresses colorectal cancer metastasis by modulating the epithelial-to-mesenchymal transition and anoikis. Cell Death &Disease. 2017； 8(4): e2739.” （标注基金号91629302、31270818、91029714、81572790、30873017）

　　经依托单位调查，上述论文存在图片不当操作及实验数据混乱等问题，通讯作者汤华对上述问题负主要责任。此外，汤华将上述论文多次列入其7项国家自然科学基金项目（批准号30873017、91029714、31071191、31270818、81572790、91629302、81830094）申请书、进展报告、结题报告中，还应对在项目申请书、进展报告或结题报告中存在虚假信息的客观结果负责。

　　经国家自然科学基金委员会监督委员会五届十二次会议（生命医学专业委员会）审议、国家自然科学基金委员会2022年第2次委务会议审定，决定依照《国家自然科学基金条例》第三十五条第四项、《国家自然科学基金委员会监督委员会对科学基金资助工作中不端行为的处理办法（试行）》第十六条第二项、第十七条第三项，撤销汤华国家自然科学基金项目“Hsa-miR-10a抑制结肠癌转移的分子机制研究”（批准号30873017）、“在卵巢癌细胞中miRNA与TNF-α-IKK-NF-κB信号途径基因的相互调控作用研究”（批准号91029714）、“miR-372调控宫颈癌细胞周期的机制研究”（批准号31071191）、“PSMC3对Ago2稳定性的调节及其机制研究”（批准号31270818）、“肝癌细胞中miR-615-5p的表观遗传调控及功能机制研究”（批准号81572790）、“炎性因子激活NF-κB/STAT3通过表观遗传修饰调控肿瘤细胞恶性行为及前转移微环境形成的机制研究”（批准号91629302）、“HPVE6/E7调控METTL3所介导的m6A-RNA在宫颈癌细胞中的作用与机制研究”（批准号81830094），追回上述7个项目已拨资金，取消汤华国家自然科学基金项目申请资格5年（2022年1月18日至2027年1月17日），给予汤华通报批评。

　　国家自然科学基金委员会

　　2022年3月30日

关于对武淑芳、周博等发表的论文存在图片不当操作及实验数据混乱以及项目申请书中存在虚假信息等问题的处理决定

国科金监处〔2022〕11号

　　国家自然科学基金委员会监督委员会对西安交通大学武淑芳、周博等发表的论文涉嫌学术不端开展了调查，涉事论文如下：

　　论文1：“Shufang Wu, Tal Grunwald, Alexei Kharitonenkov, Julie Dam, Ralf Jockers, Francesco De Luca*. Increased Expression of Fibroblast Growth Factor 21 (FGF21) During Chronic Undernutrition Causes Growth Hormone Insensitivity in Chondrocytes by Inducing Leptin Receptor Overlapping Transcript (LEPROT) and Leptin Receptor Overlapping Transcript-Like 1 (LEPROTL1) Expression. J Biol Chem, 2013, 288(38):27375 -27383.”（标注基金号81071440、81222026）

　　论文2:“Shufang Wu, Weijin Zang, Xu Li, Hongzhi Sun*. Proepithelin Stimulates Growth Plate Chondrogenesis via Nuclear Factor B-p65-dependent Mechanisms. J Biol Chem, 2011, 286(27): 24057-24067.”（标注基金号30930105、30971392、81071440）

　　论文3: “Shufang Wu, Janna K Flint, Geoffrey Rezvani, Francesco De Luca*. Nuclear factor-kappaB p65 Facilitates Longitudinal Bone Growth by Inducing Growth Plate Chondrocyte Proliferation and Differentiation and by Preventing Apoptosis. J Biol Chem, 2007, 282(46):33698-33706.”

　　论文4：“QinyueGuo, Qindong Shi, Huixia Li, Jiali Liu, ShufangWu, HongzhiSun, Bo Zhou*. Glycolipid Metabolism Disorder in the Liver of ObeseMice Is Improved by TUDCA via the Restoration of Defective HepaticAutophagy. Int J Endocrinol, 2015:687938.”（标注基金号81460287、81472038、81500016）

　　论文5：“Bo Zhou, Huixia Li, Lin Xu, Weijin Zang, Shufang Wu, Hongzhi Sun*. Osteocalcin reverses endoplasmic reticulum stress and improves impaired insulin sensitivity secondary to diet-induced obesity through nuclear factor-κB signaling pathway. Endocrinology, 2013, 154(3):1055-1068.”（标注基金号30930105、30971392、81170741、81071440）

　　经查，论文1、2、3存在图片不当操作及实验数据混乱等问题，第一作者武淑芳负主要责任。此外，武淑芳将3篇论文多次列入其国家自然科学基金项目（批准号81071440、81222026、81472038、81672221、81871813）申请书中，还应对在项目申请书中存在虚假信息的客观结果负责；论文4、5存在图片不当操作及实验数据混乱等问题，周博（论文4通讯作者及论文5第一作者）负主要责任。此外，周博将论文4列入其国家自然科学基金项目（批准号81500016）结题报告中，将论文5列入其国家自然科学基金项目（批准号81500016）申请书中，还应对在项目申请书和结题报告中存在虚假信息的客观结果负责。

　　经国家自然科学基金委员会监督委员会五届十二次会议（生命医学专业委员会）审议、国家自然科学基金委员会2022年第2次委务会议审定，决定依照《国家自然科学基金委员会监督委员会对科学基金资助工作中不端行为的处理办法（试行）》第十六条第二项、第十七条第三项，撤销武淑芳国家自然科学基金项目“FGF21介导"生长激素不敏感状态"软骨发育迟滞的机制研究”（批准号81071440）、“自噬调节在软骨功能障碍相关疾病的作用机制研究”（批准号81222026）、“外周生物钟紊乱在生长激素不敏感状态软骨功能异常的作用机制研究”（批准号81472038）、“Sirt1对软骨内成骨及软骨稳态维持的调控机制研究”（批准号81672221）、“外周神经递质NPY在软骨退变的直接作用与机制研究”（批准号81871813），追回上述5个项目已拨资金，取消武淑芳国家自然科学基金项目申请资格3年（2022年1月18日至2025年1月17日），给予武淑芳通报批评；决定依照《国家自然科学基金条例》第三十五条第四项、《国家自然科学基金委员会监督委员会对科学基金资助工作中不端行为的处理办法（试行）》第十六条第二项、第十七条第三项，撤销周博国家自然科学基金项目“自噬在化学伴侣改善支气管哮喘气道炎症中的调控机制研究”（批准号81500016），追回已拨资金，取消周博国家自然科学基金项目申请资格2年（2022年1月18日至2024年1月17日），给予周博通报批评。

　　国家自然科学基金委员会

　　2022年3月30日

关于对隋新兵等发表的论文存在图片不当操作和使用混乱以及项目申请书中存在虚假信息等问题的处理决定

国科金监处〔2022〕13号

　　国家自然科学基金委员会监督委员会对隋新兵（先后就职于浙江大学、杭州师范大学）等发表的论文涉嫌学术不端开展了调查，涉事论文如下：

　　论文1：“Xinbing Sui#, Yong Fang, Haizhou Lou, Kaifeng Wang, Yu Zheng, Fang Lou, Wei Jin, Yinghua Xu, Wei Chen, Hongming Pan*, Xian Wang#, Weidong Han*. p53 suppresses stress-induced cellular senescence via regulation of autophagy under the deprivation of serum. Molecular Medicine Reports, 2015, 11(2):1214-1220.”（标注基金号81301891、81272593、81071651、81071963）

　　论文2：“Xinbing Sui#, Na Kong#, Xian Wang, Yong Fang, Xiaotong Hu, Yinghua Xu, Wei Chen, Kaifeng Wang, Da Li, Wei Jin, Fang Lou, Yu Zheng, Hong