头孢地尼胶囊RTU60分钟质的参考色谱图贡A~U) 2.杂质杂质AOH C5H6N4O2S186.20 (Z)-2-(2-氨基噻唑-4-基)-2-(羟基亚氨基)乙酰胺杂质BCOoHOH OH2N C14H13N5O6S2411.41 (6S,7R)-7-[(Z)-2-(2-氨基噻唑-4-基)-2-(羟基亚氨基)乙酰氨基]-8氧代-3-乙烯基-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸5-氧化物杂质C H2NIII HH(6R,7R)-7-氨基-8-氧代-3-乙烯基-5-硫杂1-氮杂双环4.2.0]辛-2-烯-2-羧酸(7-AVCA)杂质DCOOH C14H13N5O6S2411.41 (6R,7R)-7-(Z)-2-(2氨基噻唑-4-基)-2-(羟基亚氨基)乙酰氨基]-8-氧代-3-乙烯基-5-硫杂-1-氮杂双环[4.2.0]辛-2烯-2-羧酸5-氧化物杂质ECOOHOHo、OHH2N C14H15N5O6S2413.43 (Z)-2-[(R)-[(Z)-2-(2-氨基噻唑-4-基)-2-(羟基亚氨基)乙酰氨基](羧基)甲基]5-亚乙基5,6-二氢2H-1,3-噻嗪-4羧酸 杂质FCOOHHH2NHH C14H13N5O5S2395.41 (6R,7R)-7-[(z)-2-(2-氨基噻唑-4基)-2-(羟基亚氨基乙酰氨基]8-氧代-3-乙烯基5-硫杂-1-氮杂双环[4.2.0]辛3烯-2-羧酸杂质GCOOH C13H13N5O5S2383.40 (Z)-7-[2-(2氨基噻唑-4基)-2-(羟基亚氨基)乙酰氨基3-甲基-8-氧代5-硫杂-1-氮杂双环[4.2.0辛-2-烯-2-羧酸(3-甲基-头孢地尼)杂质HCOOHOH OH2N C14H15N5O6S2413.43 (6R,7R)-7-[(Z)-2-(2-氨基噻唑-4-基)-2-(羟基亚氨基乙酰氨基]-3-(2-羟基乙基)-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸杂质IHH2N H COOH C14H15N5O6S2413.43 (R)-2-[(Z)-2-(2氨基噻唑-4-基)-2-(羟基亚氨基)乙酰氨基]2[(2R,5S)-5-甲基7氧代2,4,5,7-四氢1H-呋喃并[3,4-d[1,3J噻嗪-2-基]乙酸杂质JH'CHH2N一 C14H15N5O6S2413.43 (R)-2[(Z)-2-(2氨基噻唑-4基)2-(羟基亚氨基)乙酰氨基]2[(2R,5R)-5甲基7-氧代2,4,5,7-四氢-1H-呋喃并[3,4-d][1,3]噻嗪2-基]乙酸 杂质HH O H COOh (R)-2-[(Z)-2-(2-氨基噻唑-4-基)-2-(羟基亚氨基)乙酰氨基]2-[(2S,5R)-5-甲基7-氧代-2,4,5,7-四氢-1H-呋喃并[3,4-d][1,3]噻嗪-2-基]乙酸杂质LCHH2N H COOH C14H15N5O6S2413.43 (R)-2-[(Z)-2-(2氨基噻唑-4-基)-2-(羟基亚氨基)乙酰氨基]-2[(2S,5S)-5-甲基7氧代-2,4,5,7-四氢-1H-呋喃并[3,4-d][1,3]噻嗪-2-基]乙酸杂质MOHHH C14H13N5O5S2395.41 (Z)-2-(2-氨基噻唑-4-基)-2-(羟基亚氨基)N-[(5aR6R)-3-甲基-1,7-二氧代-1,3,4,5a,6,7-六氢氮杂环丁二烯并[2,1-b]呋喃并[3,4-d][1,3]噻嗪-6-基]乙酰胺杂质NCOOHH2NHH H13N5O5S2395 (6R,7S)-7-[(Z)-2-(2-氨基噻唑-4基)-2(羟基亚氨基)乙酰氨基]8氧代3乙烯基-5-硫杂-1-氮杂双环[4.2.0]辛-2烯-2-羧酸(7S-头孢地尼) 杂质OCOOHH2NHH C14H14N4O4S2366.42 (6R,7R)-7-[2-(2-氨基噻唑-4基)乙酰氨基]8-氧代-3乙烯基-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯2-羧酸杂质PaH H COOH C14H15N5O6S2413.43 (R)-2[(E)-2-(2-氨基噻唑-4-基)-2-(羟基亚氨基)乙酰氨基]2-[(2R,5S)-5-甲基7氧代2,4,5,7-四氢-1H-呋喃并[3,4d][1,3]噻嗪-2-基]乙酸杂质QHHN H COOH C14H15N5O6S2413.4 (R)-2[(E)-2-(2-氨基噻唑-4-基)-2-(羟基亚氨基)乙酰氨基]2[(2R,5R)-5-甲基7-氧代2,4,5,7四氢-1H呋喃并[3,4-d][1,3]噻嗪-2-基]乙酸杂质R2SHH C14H13N5O5S2395. (6R,7R)-7-(F)-2-(2-氨基噻唑-4基)-2-(羟基亚氨基)乙酰氨基]-8-氧代-3-乙烯基-5-硫杂-1-氮杂双环[4.2.0辛-2-烯-2-羧酸 杂质SCOOHHH C16H15N5O6S2437.45 (6R,7R)-7[(E)-2-(乙酰氧基亚氨基)-2-(2-氨基噻唑4-基)乙酰氨基]-8-氧代-3-乙烯基5-硫杂-1-氮杂双环[4.2.0]辛-2-烯2-羧酸(N-乙酰氧基头孢地尼)杂质THH2N一 C13H15N5O4S2369.42 (Z)-2-(2-氨基噻唑-4基)-2-(羟基亚氨基)-N-[(2RS)-5-甲基7-氧代2,4,5,7-四氢-1H-呋喃并[3,4-d][1,3]噻嗪-2-基甲基]乙酰胺杂质∥CH3 C13H15N5O4S2369.42 (Z)-2-(2-氨基噻唑-4基)2(羟基亚氨基)N-[(2R,5R)-5-甲基-7-氧代-2,4,5,7-四氢-1H-呋喃并[3,4d][1,3]噻嗪-2-基甲基]乙酰胺