实验动物代谢监测系统(笼统地称为代谢笼)选择需要关注的问题


目前,全球及中国糖尿病肥胖等代谢疾病的发病率越来越高,越来越需要我们认真去研究对待,因此对糖尿病肥胖等代谢疾病的研究越来越多。

     该研究一般以大小鼠为实验对象,通过大小鼠的呼吸商(即呼入氧气和呼出二氧化碳的比值)来对大小鼠的能量消耗进行评估,除此之外可能需要给大小鼠提供喂食饮水,并对喂食饮水进行量和次数的监测,也需要对其尿液进行收集,也需要同时监测活动情况,体重 心率等功能的监测。

       国内外现在对糖尿病和肥胖营养等疾病研究越来越深入:以下是一些相关的文章做参考:

客户名称

作者

发表文章

收录杂志

南京大学模式动物中心

高翔

Interaction of MAGED1 with nuclear receptors

affects circadian clock function

EMBO Journal

中科院营养所

郭非凡

Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue

Diabetes

ATF4 regulates lipid metabolism and thermogenesis

CELL RESEARCH



中科院营养所

刘勇

Abrogation of Hepatic ATP-Citrate Lyase Protects

Against Fatty Liver and Ameliorates Hyperglycemia in

Leptin Receptor-Deficient Mice

HEPATOLOGY

Tyrosine-dependent and -independent actions

of leptin receptor in control of energy balance

and glucose homeostasis

PNAS美国科学院院刊



Signaling through Tyr985 of Leptin Receptor as an

Age/Diet-Dependent Switch in the Regulation

of Energy Balance

MOLECULAR AND CELLULAR BIOLOGY



A high-fat, ketogenic diet induces a unique metabolic state in mice

Adam R. Kennedy,1 Pavlos Pissios,1 Hasan Otu,2 Bingzhong Xue,1 Kenji Asakura,1 Noburu Furukawa,1 Frank E. Marino,1 Fen-Fen Liu,1 Barbara B. Kahn,1 Towia A. Libermann,2 and Eleftheria Maratos-Flier1Am J Physiol Endocrinol Metab 292: E1724-E1739, 2007

Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice

Alexander V. Mayorova,b, Neri Amarac, Jason Y. Changa,b, Jason A. Mossa,b Mark S. Hixona,b, Diana I. Ruiza,b, Michael M. Meijlerc,1, Eric P. Zorrillad,e,1, and Kim D. Jandaa,b,f,g,1
PNAS November 11, 2008 vol. 105 no. 45 17487-17492

A Novel Method for High Throughput Phenotyping of Sleep in Mice

Allan I Pack1*, Raymond J. Galante2, Greg Maislin1, Jacqueline Cater2, Dimitris Metaxas3, Shan Lu3, Lin Zhang2, Randy Von Smith4, Timothy Kay2, Jie Lian2, Karen Svenson4, and Luanne L Peters5Physiol. Genomics (September 19, 2006). doi:10.1152/physiolgenomics.00139.2006

Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor

Andrea Frassettoa, Jiaping Zhanga, Julie Z. Laoa, Amanda Whiteb, Joseph M. Metzgerb, Tung M. Fonga and Richard Z. Chena

Brain Research Volume 1236, 21 October 2008, Pages 140-144

Hemodynamic effects of substance P and its receptor antagonist RP67580 in anesthetized rats with carbon tetrachloride-induced cirrhosis

Andres Cardenas ab; Robert Lowe c; Sangik Oh a; Sheila Bodkin c; Tom Kenney c; Wayne W. Lamorte d; Nezam H. Afdhal a
Scandinavian Journal of Gastroenterology, Volume 43, Issue 3 2008 , pages 328 - 333