实验动物代谢监测系统(笼统地称为代谢笼)选择需要关注的问题
该研究一般以大小鼠为实验对象,通过大小鼠的呼吸商(即呼入氧气和呼出二氧化碳的比值)来对大小鼠的能量消耗进行评估,除此之外可能需要给大小鼠提供喂食饮水,并对喂食饮水进行量和次数的监测,也需要对其尿液进行收集,也需要同时监测活动情况,体重 心率等功能的监测。
国内外现在对糖尿病和肥胖营养等疾病研究越来越深入:以下是一些相关的文章做参考:
客户名称 | 作者 | 发表文章 | 收录杂志 |
南京大学模式动物中心 | 高翔 | Interaction of MAGED1 with nuclear receptors affects circadian clock function | EMBO Journal |
中科院营养所 | 郭非凡 | Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue | Diabetes |
ATF4 regulates lipid metabolism and thermogenesis | CELL RESEARCH | ||
中科院营养所 | 刘勇 | Abrogation of Hepatic ATP-Citrate Lyase Protects Against Fatty Liver and Ameliorates Hyperglycemia in Leptin Receptor-Deficient Mice | HEPATOLOGY |
Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis | PNAS美国科学院院刊 | ||
Signaling through Tyr985 of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance | MOLECULAR AND CELLULAR BIOLOGY |
A high-fat, ketogenic diet induces a unique metabolic state in mice
Adam R. Kennedy,1 Pavlos Pissios,1 Hasan Otu,2 Bingzhong Xue,1 Kenji Asakura,1 Noburu Furukawa,1 Frank E. Marino,1 Fen-Fen Liu,1 Barbara B. Kahn,1 Towia A. Libermann,2 and Eleftheria Maratos-Flier1Am J Physiol Endocrinol Metab 292: E1724-E1739, 2007
Alexander V. Mayorova,b, Neri Amarac, Jason Y. Changa,b, Jason A. Mossa,b Mark S. Hixona,b, Diana I. Ruiza,b, Michael M. Meijlerc,1, Eric P. Zorrillad,e,1, and Kim D. Jandaa,b,f,g,1
PNAS November 11, 2008 vol. 105 no. 45 17487-17492
A Novel Method for High Throughput Phenotyping of Sleep in Mice
Allan I Pack1*, Raymond J. Galante2, Greg Maislin1, Jacqueline Cater2, Dimitris Metaxas3, Shan Lu3, Lin Zhang2, Randy Von Smith4, Timothy Kay2, Jie Lian2, Karen Svenson4, and Luanne L Peters5Physiol. Genomics (September 19, 2006). doi:10.1152/physiolgenomics.00139.2006
Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor
Andrea Frassettoa, Jiaping Zhanga, Julie Z. Laoa, Amanda Whiteb, Joseph M. Metzgerb, Tung M. Fonga and Richard Z. Chena
Brain Research Volume 1236, 21 October 2008, Pages 140-144
Andres Cardenas ab; Robert Lowe c; Sangik Oh a; Sheila Bodkin c; Tom Kenney c; Wayne W. Lamorte d; Nezam H. Afdhal a
Scandinavian Journal of Gastroenterology, Volume 43, Issue 3 2008 , pages 328 - 333