Ratio Distortion with Isobaric Multiplexing
Problem: Quantitation of low-abundance proteins in a complex background is distorted by co-isolated interfering precursor ions
Synchronous Precursor Selection (SPS) for Accurate Quantification
TMT3 Experiment, Powered by SPS
Co-isolation of Interfering Ions Affects Accuracy
Results: Best possible accuracy and precision by reducing co-isolated interfering ions.
Enhanced Differences Using SPS MS3 Quantitation
Thermo Poster Note : Towards Mechanism of EGFR Inhibitor Resistance in Non-Small Lung Cancer Cell;M.Blank. et al
…While Still Getting Proteome Coverage
The speed and parallelizable work flow of the Orbitrap Fusion means not choosing between accuracy and coverage…
The Orbitrap Fusion using multinotch can Quantify more proteins than were Identified on the previous generation top tier hybrid
…Don’t Settle
Orbitrap Fusion Lumos Tribrid Mass Spectrometer
2015
Unmatched Analytical Performance
Revolutionary performance
Exceptional versatility
Unprecedented usability
Highest sensitivity