发布时间:2022-08-22 10:10 原文链接: PPP4R2基因编码的功能和结构描述

该基因编码的蛋白质是丝氨酸/苏氨酸蛋白磷酸酶4复合物的调节亚单位。这种复合物除了能有效修复DNA双链断裂外,还参与中心体微管的组织和剪接体snrnp的加工已经发现了一些编码不同亚型的转录变体。

The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centrosomes and processing of spliceosomal snRNPs. Several transcript variants encoding different isoforms have been found for this gene.