RoleofMEF2DinTcellApoptosis

Mef2 (Myocyte enhancer factor 2) transcription factors play a role in T-Cell Calcium Induced Apoptosis. Several factors regulate Mef2 transcription factors, including Map kinases and histone deacetylase (HDAC) enzymes. See also Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) pathway.

Contributor:

REFERENCES: Esau C, Boes M, Youn HD, Tatterson L, Liu JO, Chen J. Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells. J Exp Med. 2001 Nov 19;194(10):1449-59. Kim MJ, Jo DG, Hong GS, Kim BJ, Lai M, Cho DH, Kim KW, Bandyopadhyay A, Hong YM, Kim do H, Cho C, Liu JO, Snyder SH, Jung YK. Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9870-5. Liu W, Youn HD, Liu JO. Thapsigargin-induced apoptosis involves Cabin1-MEF2-mediated induction of Nur77. Eur J Immunol. 2001 Jun;31(6):1757-64. Sun L, Youn HD, Loh C, Stolow M, He W, Liu JO. Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. Immunity. 1998 Jun;8(6):703-11. Youn HD, Chatila TA, Liu JO. Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis. EMBO J. 2000 Aug 15;19(16):4323-31. Youn HD, Liu JO. Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2.Immunity. 2000 Jul;13(1):85-94. Youn HD, Sun L, Prywes R, Liu JO. Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2. Science. 1999 Oct 22;286(5440):790-3.