SRY相关的HMG-box（SOX）基因编码一个DNA结合蛋白家族，该家族含有79个氨基酸HMG（高迁移率基团）结构域，与SRY蛋白（MIM 480000）的DNA结合HMG-box具有至少50%的序列同源性根据hmg域内外的序列相似性，sox蛋白被分成6个亚群。有关sox基因的其他背景信息，请参见sox1（mim 602148）。
SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).