Peptide-Based Drug Design: Methods and Protocols (Methods in Molecular Biology)
By Laszlo Otvos
Publisher: Humana Press
Number Of Pages: 304
Publication Date: 2008-09-12
ISBN-10 / ASIN: 1588299902
ISBN-13 / EAN: 9781588299901
Binding: Hardcover
Product Description:
Due to their high specificity and low toxicity profile, peptideshave once again become central to the development of new drugs. InPeptide-Based Drug Design: Methods and Protocols, expert researchersprovide a handbook which offers a selection of research and productiontools suitable for transforming a promising protein fragment orstand-alone native peptide into a pharmaceutically acceptablecomposition. The volume delves into contemporary, cutting-edge subjectssuch as hit isolation and target validation, computer-aided design,sequence modifications to satisfy pharmacologists, in vivo stabilityand imaging, and the actual production of difficult sequences. Writtenin the highly successful Methods in Molecular Biology™ series format,chapters include readily reproducible, step-by-step laboratoryprotocols, lists of materials, and the Notes section, which highlightstips on troubleshooting and avoiding known pitfalls.
Comprehensive and up-to-date, Peptide-Based Drug Design: Methodsand Protocols shows its subject to be an independent science on therise, and provides scientists with a clear, concise guide forcontinuing this vital research.