发布时间:2022-07-26 12:45 原文链接: DOT1L基因突变与药物因子介绍

这个基因编码的蛋白质是组蛋白甲基转移酶,它使组蛋白h3的赖氨酸-79甲基化。它对游离核心组蛋白不起作用,但对核小体显示出显著的组蛋白甲基转移酶活性。[由RefSeq提供,2011年8月]
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]