WIKI资讯
WIKI资讯
PTEN is a tumor suppressor gene. Recombinant PTEN is capable of dephosphorylating phosphatidylinositol 3,4,5-triphosphate[PI(3,4,5)P3], the product of phosphatidylinositol 3 -kinase. Many of the cancer-related mutations have been mapped to the phosphatase catalytic domain, it has been suggested that the phosphatase activity of PTEN is required for its tumor suppressor function. The activation of PKB/AKT is regulated ......阅读全文
2.2 Interaction mating - large scaleWith a few modifications, the procedure described above can be used to test for interactions between a single prey
实验概要Live cell studies of cellular DNA content and cell cycle distribution are useful to detect variations of growth patterns due to a vari
Cyclins are proteins that associate with cyclin-dependent protein kinases to regulate their activity and the progression of the cell cycle through spe
3. Commentary 3.1. Background informationApoptosis is an innate mechanism of eukariotic cell suicide which plays a major role i
B.3. COMMENTARY B.3.1 Background information The critical steps in the methodology are cell fixation, permeabilization and the concentration
TNF acts on several different signaling pathways through two cell surface receptors, TNFR1 and TNFR2 (See TNFR1 and TNFR2 Signaling Pathways) to regul
实验概要Provides a rapid and convenient assay for apoptosis. 实验原理Apoptosis is a carefully regulated process of cell death that occurs as a norm
一个月发表30多篇10分以上的文章，到底是何方神圣？答案：RNA甲基化。今天小编先来介绍一下m6A RNA甲基化。 m6A是真核细胞中mRNAs丰度最高的甲基化修饰，在包括组织发育、干细胞自我更新和分化、热休克以及DNA损伤应答，母本合子(maternal-to-zygotic)转化等多个
一个月发表30多篇10分以上的文章，到底是何方神圣？答案：RNA甲基化。今天小编先来介绍一下m6A RNA甲基化。m6A是真核细胞中mRNAs丰度最高的甲基化修饰，在包括组织发育、干细胞自我更新和分化、热休克以及DNA损伤应答，母本合子(maternal-to-zygotic)转化等多个重要的生物学
引言血球计数板一直是实验室细胞计数的金牌标准。自从18世纪在法国第一次被用于分析病人的血液样本，血球计数板在过去几百年中已经得到一系列的重大发展，相比以前计数更为精确、使用更为简单，并最终形成了今天我们使用的样子。现在血球计数板计数仍然是所有细胞学研究的一个组成部分，然而其计数存在的问题由于自身固有
E2F-1 is a transcription factor that regulates the expression of genes involved in the cell cycle and that is involved in progression of the cell cycl
Terminal differentiation of cells is often accompanied by repression of cellular proliferation, suggesting that there is a mechanism by which these ce
多功能单细胞显微操作系统FluidFM BOT在活细胞提取中的应用由于细胞异质性的存在，单细胞层面的分析就变得十分重要。目前对于单细胞分析的方法主要还是通过化学、生物学的方法进行裂解后，提取内容物进行分析，然而这种方法往往会对样本造成一些损伤。直接提取活细胞具有诸多优点，但是操作苦难。如今一种全新使
由于细胞异质性的存在，单细胞层面的分析就变得十分重要。目前对于单细胞分析的方法主要还是通过化学、生物学的方法进行裂解后，提取内容物进行分析，然而这种方法往往会对样本造成一些损伤。直接提取活细胞具有诸多优点，但是操作苦难。如今一种全新使用FluidFM科技的技术新报道有望提供一种活细胞提取新型的简易方
Our experience indicates that it may not be sufficient to change the medium containing Rottlerin and to wash the cells before adding MTT to avoid a po
Initiation of DNA replication in eukaryotes is a highly conserved, multi-step process (replication licensing) designed to restrict initiation events t
Receptors in the TNF receptor family are associated with the induction of apoptosis, as well as inflammatory signaling. The Fas receptor (CD95) mediat
The differentiation of muscle cells is transcriptionally regulated, in part by the myocyte enhancer factor-2, MEF2. During myogenesis MEF2 binds to My
Homeodomain transcription factors comprise a large family of DNA binding factors that regulate transcription and development. Many homeodomain genes a
Mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein
蛋白酶caspase-8同时具有诱导和抑制细胞死亡的功能：它可以通过死亡受体（Death receptor），比如TNFR1来诱导细胞凋亡（Apoptosis）【1】，同时，也可以通过激酶RIPK3和MLKL来抑制细胞坏死（Necroptosis）【2-4】。caspase-8缺失或者突变（CA
p27/Kip1 regulates the cell cycle by inhibiting the checkpoint kinase cdk2/cyclin E and blocking cell cycle progression through the G1-S transition. C
The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted f
郑利民 教授 1984年毕业于上海医科大学后在附属华山医院任临床医生，94年获荷兰莱顿（Leiden）大学细胞生物和免疫学博士学位，1999年获瑞典国家研究院人才基金（助理教授）资助而在瑞典林雪平大学建立了独立的实验室。2002年被聘为中山大学教授，博士导师。现任中山大学生命科学院生物化学系主
Overview1) Purpose: Data Independent Acquisition (DIA) has been applied for large-scale protein and PTM quantification on the Thermo Scientific ™
The polyamines spermidine and spermine are expressed in a variety of tissues and are involved in the regulation of apoptosis, cellular proliferation,
来自杜兰大学（Tulane University）健康科学中心，台湾荣民总医院（Veterans General Hospital-Taipei），阳明大学等处的研究人员利用缺氧的环境培养人类骨髓间叶性干细胞，取得了突破性的研究成果。这一研究成果公布在最新一期的国际干细胞权威期刊《干细胞》上。
生物学NATURE REVIEWS MOLECULAR CELL BIOLOGY140.272NATURE REVIEWS GENETICS139.215CELL130.173NATURE GENETICS128.9NATURE REVIEWS MICROBIOLOGY127.799NATURE M
The plasticity of differentiated adult cells could have a great therapeutic potential, but at the same time, it is characteristic of progression of se
Materials and MethodsCell culture conditions and surface transitionCryopreserved hiPSCs (SC102A-1, SBI™, USA) were initially thawed and pre-cultivat