References1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA: a cancer journal for clinicians. 2015; 65: 87-108.2. Hall-Craggs MA, Vaidya JS. Minimally invasive therapy for the treatment of breast tumours. European journal of radiology. 2002; 42: 52-7.3. Vogl TJ, Farshid P, Naguib NN, Zangos S. Thermal ablation therapies in patients with breast cancer li......阅读全文
Interleukin-6 Induced Acute Phenotypic Microenvironment Promotes Th1 Anti-Tumor ImmunityTing Xue1, Ping Liu1, Yong Zhou2, Kun Liu1, Li Yang2, Robert L
In this study, we found that “acute” response was strongly induced by cryo-thermal therapy with “acute” and high expression of a series of acute p
Cryo-thermal therapy induced an “acute” phase response First, we performed PRM analysis upon significant proteins involved in acute phase respo
ConclusionIn summary, using comprehensive discovery proteomics analysis followed by target proteomics validation at a large scale sample size, we
在免疫学实验中,比如WB,IHC,IF等,大家都知道选着好正确的一抗,往往实验就成功了一大半,因此,往往很多研究者便会忽视对二抗,以及其它试剂盒品质的追求。二抗是一种相对而言比较稳定的产品,包装大,因此很多实验室都会公用一个二抗。但如果二抗没有选择好的话,影响的可能就是一整个实验室或者课题组了。艾美
As a primary component of circulatory system, serum is the major reservoir of thousands of proteins secreted or “leaked” from a broad spectrum of
【摘要】 血清淀粉酶的测定仍是诊断急性胰腺炎的最常用的生化标志物。但就诊较晚,高甘油三酯血症和慢性酒精中毒患者的血清淀粉酶的敏感性降低。尿胰蛋白酶原-2是个合适的、有较高诊断准确性的生化标志物。重症急性胰腺炎在发病48h内通过有效的评分系统可早期诊断,但新的血清生化标志物,如降钙素原和IL-6在急性
IntroductionFetal Alcohol Syndrome (FAS) is caused by exposure of the developing embryo to alcohol, one of several teratogenic agents which adversely
Results Enterotoxin Induced Histamine and LTC4 Release. Basophils from healthy subjects did not release more than 2 % histamine to any staphy
IL-7 is a key cytokine in the immune system, essential for normal development of B cells and T cells. Mice with the IL-7 receptor deleted lack B and T
The strongest and unique “acute” environment induced by cryo-thermal therapy stimulated the most effective anti-tumor immune response As desc
In summary, we suggested that “acute” response could elicit innate and Th1 adaptive immunity, reversing the tumor-mediated immunosuppressive envir
The IL-2 receptor is a key component of immune signaling and is required for the activation, proliferation, and survival of T cells. This receptor is
AbstractPrevious studies by Stachel and colleagues indicate that lithium chloride induction of post-midblastular Brachydanio rerio embryos r
摘要:目的 研究中药药对虎杖-桂枝对急性痛风性关节炎的影响。方法 取雄性 SD 大鼠 48 只,随机分为 6组(每组 8 只),即正常对照组,模型组,秋水仙碱组(0.1 g·kg-)1,虎杖-桂枝低、中、高剂量组(3.5,7,14 g·kg-)1。正常对照组和模型组给予等量生理盐水,其他各组给予相
IL-10 is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by
摘要:目的 研究中药药对虎杖-桂枝对急性痛风性关节炎的影响。方法 取雄性 SD 大鼠 48 只,随机分为 6组(每组 8 只),即正常对照组,模型组,秋水仙碱组(0.1 g·kg-)1,虎杖-桂枝低、中、高剂量组(3.5,7,14 g·kg-)1。正常对照组和模型组给予等量生理盐水,其他各组给予
摘要:目的 研究中药药对虎杖-桂枝对急性痛风性关节炎的影响。方法 取雄性 SD 大鼠 48 只,随机分为 6组(每组 8 只),即正常对照组,模型组,秋水仙碱组(0.1 g·kg-)1,虎杖-桂枝低、中、高剂量组(3.5,7,14 g·kg-)1。正常对照组和模型组给予等量生理盐水,其他各组给予
动物术中和术后保温是动物实验过程中的一个至关重要的环节,是否做好保温措施直接关系到实验的成败,同时也是科研工作者在进行生命科学相关研究中将实验动物伦理和福利付诸实践的真正体现,是对动物爱心的社会责任感的体现。善待活着的动物,减少动物死亡的痛苦!动物手术保温的科学价值Responsible scien
环孢素A(cyclosporin A,CsA)是一种强效免疫抑制剂,广泛应用于器官移植后抗排斥,及自身免疫性疾病的治疗。CsA诱导的牙龈肥大(CsA induced gingivalo vergrowth,CIGO)属于药物性牙龈增生(drug induced gingival overgrow
Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with the
张新超 北京医院急诊科 在临床实践中,没有哪个器官系统病症像心血管疾病在救治时效性方面的意义更为突出。急性心肌梗死(acute myocardial infarction,AMI)后1 h内得到再灌注治疗,死亡率为1%,6 h内得到治疗,死亡率约为10%~12%
Ambion and Applied Biosystems have joined forces to provide a complete convenient, solution for performing gene silencing experiments and validating t
Circulating bone marrow (BM)–derived endothelial progenitor cells (EPCs) are recruited to the site of tissue regeneration and substantially contri
生物分子发表的代表性文献 QTRAP:同时具有三重四极杆和线性离子阱性能的独一无二的LC/MS/MS系统 QTRAP系统最早在ASMS 2002上,作为第一台商用的线性离子阱发布,是世界上唯一的线性离子阱和三重四极杆的复合
Target analysis by Parallel reaction monitoring (PRM)The targeted quantification and verification were carried out in 94 serum samples with 5~
血糖监测是糖尿病管理的重要内容。已有多项大型临床研究证实,糖化血红蛋白(HbA1c)与糖尿病慢性并发症的发生存在关联,将HbA1c水平控制在合适的范围内可以有效降低慢性并发症的风险,因此,长久以来HbA1c一直被视作评价糖尿病患者长期血糖控制状况的金标准[1]。然而,血红蛋白的更新速度异常,某些情况
昨日,美国FDA批准了全球第二个CAR-T上市,用于治疗特定非霍奇金淋巴瘤,这是继诺华的首个CAR-T疗法的又一次重大突破。肿瘤免疫疗法频传捷报,特别是以嵌合抗原受体T细胞技术(CAR-T)以及免疫检查点阻断技术为代表的新兴肿瘤免疫疗法,发挥着巨大潜力。考虑到该疗法临床前评估需要接近人类免疫系统且具
为了跟前文“关节炎中软骨破坏方向的细胞模型”相对应,这里标题还用了“关节炎”这个描述,但其实,关节炎中涉及滑膜炎症的主要是类风湿关节炎(rheumatoid arthritis,RA)。也是关节炎中研究最广泛的类型之一。在类风湿关节炎发病进展中,至少涉及三大类细胞,免疫细胞,骨细胞,滑膜细胞。免疫细
随着人类基因组计划(human genome project )在2003年顺利完成,基因组测序技术取得了长足的进步,这直接导致了每兆基因组成本的大幅下降以及检测的基因组数量越来越多。人们对基因组的复杂性深感震惊,这也引导着测序技术的进一步发展。最近的一些突破性技术使得测序技术在更短的时间内可以