WIKI资讯
WIKI资讯
Programmed cell death is induced by many different factors and involves numerous signaling pathways, some dependent on caspase proteases and others that are caspase independent. Like cytochrome C, AIF (apoptosis-inducing factor) is a protein found in mitochondria that is released from mitochondria by apoptotic stimuli. While cytochrome C is linked to caspase-dependent apoptotic signaling, AIF release stimulates caspa......阅读全文
Over 1,000 papers and reviews have been written about the role of ceramide in the production of programmed cell death or apoptosis. Ceramide is a sphi
【关键词】 肝细胞 肝细胞凋亡的病理学特征为肝细胞的嗜酸性变，又称嗜酸性坏死。表现为个别肝细胞胞浆的嗜伊红性增强，胞核固缩直至消失，形成嗜酸小体（eosinophilic body），脱离肝细胞索坠入肝窦或窦间隙。周围可出现CTL、枯否细胞，将凋亡小体
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutate
Erythropoietin (Epo) is most commonly known as the cytokine secreted by the kidneys that stimulates red blood cell production and is used as a drug fo
第五届金属组学国际研讨会会议日程 Scientific Programme Wednesday, 9th Sept 2015 9:00 -21:00 Registration Wednesday, 9th Sept 2015, Ginkgo Hall
实验概要A novel impulsive cell pressurization experiment has been developed using a Kolsky bar device to investigate blast-induced traumatic b
3 胆汁淤滞性肝病在许多临床综合征中可以观察到胆汁淤滞，胆汁淤滞是一组慢性进行肝病的主要特征，并可最终导致肝硬化、肝衰竭和死亡。肝内疏水的毒性胆盐储滞长期以来被认为是肝损伤的一个主要原因，并被认为是胆汁淤滞性肝病肝损伤的一个关键原因。事实上肝内毒性胆盐：鹅脱氧胆酸和脱氧胆酸盐的储滞水平与肝损伤的程度
The IL-2 receptor is a key component of immune signaling and is required for the activation, proliferation, and survival of T cells. This receptor is
Our experience indicates that it may not be sufficient to change the medium containing Rottlerin and to wash the cells before adding MTT to avoid a po
IntroductionIn our lab we use the term 'cell-free system' when we talk about the examination of apoptotic activity in cytoplasmic extrac
The differentiation of muscle cells is transcriptionally regulated, in part by the myocyte enhancer factor-2, MEF2. During myogenesis MEF2 binds to My
美国BARTZ公司最早研制生产微根窗根系观测仪器，BTC-100成为国际上应用最广、发表论文最多的根系研究仪器技术，其学术研究论文涵盖几十种世界知名学术期刊和专著，包括Science、Nature、Global change biology（影响因子8.502）、New
Abstract Choriallantoic membrane (CAM) limb grafting functions as a method to isolate the inductive eve
作者：钱燕春，唐 平 作者单位：（永州职业技术学院医学院，湖南永州 425000） [摘要] 目的：探讨凋亡抑制基因和凋亡促进基因bax表达与肝细胞癌生物学行为的关系及对肝细胞癌预后
Receptors in the TNF receptor family are associated with the induction of apoptosis, as well as inflammatory signaling. The Fas receptor (CD95) mediat
原文检索： Type 3 inositol 1,4,5-trisphosphate receptor negatively regulates apoptosis during mouse embryonic stem cell differentiation Ca2+ sign
Mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein
引言：上海吉凯基因化学技术有限公司成立于2002年，拥有国内最大的慢病毒文库，同时也是国内最大的疾病关键基因科研服务供应商，在疾病研究领域的实验积累已逾14年！在这里，我们为大家特别整理了10多个研究领域的经验所得，将最实用的精华分享给大家！肺癌作为世界范围内第一大常见肿瘤，这次就当仁不让先来分享，
引言：上海吉凯基因化学技术有限公司成立于2002年，拥有国内最大的慢病毒文库，同时也是国内最大的疾病关键基因科研服务供应商，在疾病研究领域的实验积累已逾14年！在这里，我们为大家特别整理了10多个研究领域的经验所得，将最实用的精华分享给大家！肺癌作为世界范围内第一大常见肿瘤，这次就当仁不让先来分
Cryo-thermal therapy induced an “acute” phase response First, we performed PRM analysis upon significant proteins involved in acute phase respo
The epidermis, which provides a protective barrier that undergoes a constant renewal, is a multi-layered tissue with the proliferating cells located i
Glycolysis was one of the first metabolic pathways studied and is one of the best understood, in terms of the enzymes involved, their mechanisms of ac
蛋白酶caspase-8同时具有诱导和抑制细胞死亡的功能：它可以通过死亡受体（Death receptor），比如TNFR1来诱导细胞凋亡（Apoptosis）【1】，同时，也可以通过激酶RIPK3和MLKL来抑制细胞坏死（Necroptosis）【2-4】。caspase-8缺失或者突变（CA
辉瑞-惠氏（Pfizer/Wyeth） Feng, Xidong（冯喜东）教授 来自辉瑞-惠氏（Pfizer/Wyeth）的Feng, Xidong（冯喜东）教授做了题为“Structure Elucidation of Natural Product Cyclic Peptides
3. 实验过程 通过分子生物学克隆技术, 应用单克隆细胞技术的筛选，将荧光素酶的基因稳定整合到预期观察的细胞的染色体内，培养出能稳定表达荧光素酶蛋白的细胞株。典型的成像过程是：小鼠经过麻醉系统被麻醉后放入成像暗箱平台，软件控制平台的升降到一个合适的视野，自动开启照明灯拍摄第一次背景图。下一步，自动关
来自杜兰大学（Tulane University）健康科学中心，台湾荣民总医院（Veterans General Hospital-Taipei），阳明大学等处的研究人员利用缺氧的环境培养人类骨髓间叶性干细胞，取得了突破性的研究成果。这一研究成果公布在最新一期的国际干细胞权威期刊《干细胞》上。
The ever evolving mitogen-activated protein kinase (MAP kinase) pathways consist of four major groupings and numerous related proteins which constitut
IGF-1R, the type 1 receptor for insulin-like growth factor, mediates cell survival and growth in response to its ligands IGF-1 and IGF-2. This tyrosin
2. 克隆形成实验细胞的克隆形成实验被广泛应用于癌症的临床和机理研究中，人们以此来评价细胞群体在体外的功能状况。其中一些重要的研究领域就包括了细胞毒性评估、细胞转化研究以及预测肿瘤细胞对各种化学治疗试剂的反应。过去，克隆计数实验是在半固体的琼脂糖双层系统上进行的，需要在显微镜下一个一个地数