RasIndependentpathwayinNKcellmediatedcytotoxicity
NK (natural killer) cells are lymphocytes distinct from B and T cells that induce perforin-mediated lysis of tumor cells and virus-infected cells. NK cell-mediated cytotoxicity is activated by glycoproteins on the cell surface (activating receptors) and inhibited by MHC-1 with self-peptide bound. The MHC-1 inhibitory signal through Ig-family or lectin receptors prevents NK cells from killing normal cells. Abnormal MH......阅读全文
Ras-Independent pathway in NK cell-mediated cytotoxicity
NK (natural killer) cells are lymphocytes distinct from B and T cells that induce perforin-mediated lysis of tumor cells and virus-infected cells. NK
NK-cell cytotoxicity assay
Outline:To measure NK cell killing, suitable target cells are labeled with 51Cr, washed and incubated together with the killer cells (and treatments).
NO2-dependent IL 12 Pathway in NK cells
Macrophages and NK cells help provide innate immunity against infection by intracellular parasites and communicate with each other to regulate this pr
抗体介导的调理作用
ADCC,antibody-dependent cell-mediated cytotoxicity 抗体依赖的细胞介导的细胞毒性作用。简而言之，就是有些杀伤性细胞在抗体的作用下产生的细胞杀伤作用。其中最主要发挥作用的细胞是NK细胞，它的表面有抗体Fc段受体，在与抗体Fc段结合的情况下可以直接杀
adcc效应是什么
adcc效应是：1、ADCC，是抗体依赖的细胞介导的细胞毒性作用（ADCC，antibody-dependent cell-mediated cytotoxicity）是指抗体的Fab段结合病毒感染的细胞或肿瘤细胞的抗原表位，其Fc段与杀伤细胞（NK细胞、巨噬细胞等）表面的FcR结合，介导杀伤细胞直
Cytotoxicity Assays Protocol
Cytotoxicity Assays ProtocolCell-mediated cytotoxicity was determined by using a standard microcytotoxicity assay. Briefly, target cells were pelleted
关于抗体的调理吞噬和ADCC的功能介绍
IgG可通过其Fc段与表面具有相应受体的细胞结合，产生不同的生物学作用。 1．调理作用（opsonization）指IgG抗体（特别是IgG1和IgG3）的Fc段与中性粒细胞、巨噬细胞表面相应的Fc受体结合，从而增强吞噬细胞的吞噬作用。例如，细菌特异性的IgG抗体可通过其Fab段与相应的细菌抗
Cr Release Cytotoxicity assay
DescriptionCytotoxic activities of mNK cells are examined in 51Cr release assay from target cells ProcedureEffector cells (mNK cells) are seeded into
IL12 and Stat4 Dependent Signaling Pathway in Th1 Development
Interleukin-12 (IL-12) promotes cell-mediated immunity by inducing Th1 cell differentiation and activation of both T cells and NK cells. Dendritic cel
免疫系统是否具有细胞毒性？
抗体依赖的细胞介导的细胞毒性作用（antibody-dependent cell-mediated cytotoxicity，ADCC）是指某些淋巴细胞对抗体标记的靶细胞的杀伤能力；另外还有补体依赖的细胞毒性作用（complement-dependent cytotoxicity，CDC）；以及既不