PolyadenylationofmRNA

Gene expression requires the coordination and integration of multiple processes, including transcription, splicing, polyadenylation, nucleocytoplasmic export, and translation of mRNAs. Posttranscriptional addition of poly (A) to the 3' end of mRNA is important process conserved from bacteria to humans. In eukarya, polyadenylation is essential for the stability of many mRNAs and also influences the efficiency of translation. Most histone-mRNAs and all sn-RNAs (except U6), however are not polyadenylated. The mature mRNA moves to the nuclear surface and is exported through nuclear pores.

Contributor: Kosi Gramatikoff, PhD

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