MechanismofProteinImportintotheNucleus
Nuclear pore complexes (NPCs) are large proteinaceous assemblies that provide the only known portals for exchanging macromolecules between the nucleus and cytoplasm. This includes the movement of small molecules and the selective, facilitated transport of large proteins and RNAs. Faithful, continuous NPC assembly is key for maintaining normal physiological function and is closely tied to proper cell division. One of ......阅读全文
Mechanism of Protein Import into the Nucleus
Nuclear pore complexes (NPCs) are large proteinaceous assemblies that provide the only known portals for exchang
Acetylation and Deacetylation of RelA in The Nucleus
Contributor: Glenn Croston Ph.D.REFERENCES: Gilmore T. The Rel/NF-kB signal transduction pathway: An introduction to the Rel/NF-kB Signal Transduction
Transcriptional activation of dbpb from mRNA
Endothelial cells respond to treatment with the protease thrombin with increased secretion of the PDGF B-chain. This activation occurs at the transcri
Cycling of Ran in nucleocytoplasmic transport
Ran is a member of the Ras family of small GTPases. Ran is an important component of many crucial nucleocytoplasmic transport pathways. The cycling of
Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
The most recognized mechanism by which peroxisome proliferators r
Calcium Signaling by HBx of Hepatitis B virus
Hepatitis B is a small DNA virus that contains only 4 open reading frames in its genome. Three of these ORFs have been identified as the envelope, cap
G-Protein Signaling Through Tubby Proteins
The tubby gene product is expressed in the brain and has been implicated by mouse genetics in obesity and other disorders such as blindness. Structura
Regulation of Spermatogenesis by CREM
The transcriptional regulator CREM plays a key role in spermatogenesis, acting as a central transcription factor triggering a cascade of transcription
Opposing roles of AIF in Apoptosis and Cell Survival
Programmed cell death is induced by many different factors and involves numerous signaling pathways, some dependent on caspase proteases and others th
Oxidative Stress Induced Gene Expression Via Nrf2
Reactive oxygen species (ROS) can damage biological macromolecules and are detrimental to cellular health. Electrophilic compounds, xenobiotics and an