RegulationoftranscriptionalactivitybyPML
The PML nuclear bodies are ring-shaped nuclear substructures associated with the regulation of transcription, transformation, cell growth, and apoptosis and are characterized by the presence of the protein PML. The activities of PML as a tumor suppressor and apoptosis inducing factor are exerted through the numerous proteins it interacts with in the PML-nuclear bodies including the tumor suppressor p53. DNA damage in......阅读全文
Regulation of transcriptional activity by PML
The PML nuclear bodies are ring-shaped nuclear substructures associated with the regulation of transcription, trans
Overview of telomerase RNA component gene hTerc Transcriptional Regulation
Telomerase is an enzyme which replicates the terminal sequences of eukaryotic chromosomes, namely the telomeres. Cells which have an unlimited replica
Basic Mechanisms of SUMOylation
Like ubiquitin, SUMO (small ubiquitin-related modifier) proteins are small protein tags that are conjugated
SUMOylation as a mechanism to modulate CtBP-dependent gene responses
Covalent attachment of one eukaryotic protein to another is a prominent posttranslational modification and Ubiquitin is the most familiar of the prote
CARM1 and Regulation of the Estrogen Receptor
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
Ca++/ Calmodulin-dependent Protein Kinase Activation
The calcium/calmodulin-dependent kinases (CaMKs) are involved in a large number of cellu
METS affect on Macrophage Differentiation
Terminal differentiation of cells is often accompanied by repression of cellular proliferation, suggesting that there is a mechanism by which these ce
ChREBP regulation by carbohydrates and cAMP
Although insulin and glucagon play important roles in regulating the response of cells to nutrients, cells also respond to carbohydrates through trans
Regulation of PGC-1a
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nucl
Control of skeletal myogenesis by HDAC &calcium/calmodulin-dependent kinase
The differentiation of muscle cells is transcriptionally regulated, in part by the myocyte enhancer factor-2, MEF2. During myogenesis MEF2 binds to My