WIKI资讯
WIKI资讯
The G2/M DNA damage checkpoint prevents the cell from entering mitosis (M phase) if the genome is damaged. The Cdc2-cyclin B kinase is pivotal in regulating this transition. During G2 phase, Cdc2 is maintained in an inactive state by the kinases Wee1 and Mt1. As cells approach M phase, the phosphatase Cdc25 is activated, perhaps by the polo-kinase Pik1. Cdc25 then activates Cdc2, establishing a feedback amplification......阅读全文
Cell cycle checkpoint controls at the G1 to S transition and the G2 to M transition prevent the cell cycle from progressing when DNA is damaged. The A
Cyclins are proteins that associate with cyclin-dependent protein kinases to regulate their activity and the progression of the cell cycle through spe
BRCA1 and BRCA2 were identified genetically as breast cancer susceptibility genes when a single copy of the gene is mutated and are involved in the ce
The focus of this pathway is to illustrate the role of Polo-like Kinase 3 (Plk3 also known as Prk and Fnk) as part of the regulatory cascade leading t
p27/Kip1 regulates the cell cycle by inhibiting the checkpoint kinase cdk2/cyclin E and blocking cell cycle progression through the G1-S transition. C
The G1/S cell cycle checkpoint controls the passage of eukaryotic cells from the first 'gap' phase (G1) into the DNA synthesis phase (S). Two
胚胎早期发育过程中，卵细胞所提供的mRNA和蛋白质调控了发育的初始阶段，包括细胞核分裂、体轴建立以及胚盘形成，这种调控称为母体效应（maternal effect）。随着胚胎的不断发育，母体mRNA逐渐消耗和降解，合子基因开始表达，发育由最初的母体效应控制转变为胚胎本身的合子基因所控制，这种转变
The cell cycle transition from G1 to S phase is a key regulatory point in the cell cycle. This transition is regulated by the checkpoint kinase cdk2 t
Most plasmids can be adequately prepped by kits containing DNA binding columns. These columns do not do a great job of separating plasmid DNA from con
Sonic Hedgehog (Shh) is a secreted protein identified genetically as an important developmental factor. Shh provides a morphogenic signal in the devel
p53 is a transcription factor who's activity is regulated by phosphorylation. The function is p53 is to keep the cell from progressing through the
Qimin Zhan Qimin Zhan, MD, is currently an Academician of the Chinese Academy of Engineering, the Executive Vice President of Peking University, Pres
Drug addiction is associated with long-term behavioral changes, suggesting a long-lived transcriptional regulator that responds to chronic drug exposu
BCEIA2019 International Summit on Analytical Instrumentation and In Vitro Diagnosis--Registration in ProgressIn recent years，In Vitro Diagnosis has be
Map kinases transduce responses to extracellular signals by a variety of routes, and communicate with other pathways through extensive crosstalk netwo
The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to
7月份即将结束了，7月份Cell期刊又有哪些亮点研究值得学习呢？小编对此进行了整理，与各位分享。 1.Cell：中科院生物物理所王艳丽/章新政课题组从结构上揭示Cas13a切割RNA机制 doi:10.1016/j.cell.2017.06.050 作为一种VI-A型CRISPR-Cas系
*张是未转染的第12代，第二章是转染后的第22代。*张图：增值率S（合成期）+G2/M（合成后期/分裂期）：21.7%第二张图：增值率S（合成期）+G2/M（合成后期/分裂期）：19.6%据此分析两者的增值没有明显的差别。虽然第二张图比*张图的S期有所增高，但G2期下降了。细胞周期是基于细胞处于不同
第一张是未转染的第12代，第二章是转染后的第22代。第一张图：增值率S(合成期)+G2/M(合成后期/分裂期 )：21.7%第二张图：增值率S(合成期)+G2/M(合成后期/分裂期)：19.6%据此分析两者的增值没有明显的差别。虽然第二张图比第一张图的S期有所增高，但G2期下降了。细胞周期
请帮忙分析一下第一张是未转染的第12代，第二章是转染后的第22代。能说明转染后的细胞增值能力强了吗，怎么看出来的。据此分析两者的增值没有明显的差别。虽然第二张图比第一张图的S期有所增高，但G2期下降了。细胞周期是基于细胞处于不同分裂时期具有不同的DNA含量而分析细胞处于不同的时期的方法。确切的说结果
Cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells i
TIGIT是T细胞免疫球蛋白和ITIM结构域蛋白，它在淋巴细胞中表达，表达最高的是效应和调节性CD4+ T细胞、滤泡辅助CD4+ T细胞、效应CD8+ T细胞和自然杀伤（NK）细胞。CD155（PVR）是TIGIT的高亲和力受体，也有实验表明CD112和CD113也与TIGIT结合，但亲和力较弱。C