NO2dependentIL12PathwayinNKcells
Macrophages and NK cells help provide innate immunity against infection by intracellular parasites and communicate with each other to regulate this process. When stimulated, macrophages secrete the cytokine IL-12 that is essential for activation of the cytotoxic activity of natural killer (NK) cells. IL-12 stimulates this NK cell response through activation of a JAK/STAT signaling pathway. Binding of IL-12 to its rec......阅读全文
淋巴因子激活的杀伤细胞的简介
LAK细胞即淋巴因子激活的杀伤细胞。将外周血淋巴细胞在体外经淋巴因子白介素-2(IL-2)激活3～5天而扩增为具有广谱抗瘤作用的杀伤细胞。把LAK输给带瘤小鼠，不但使原瘤消退，还可以使已确立的转移瘤消失。LAK有广谱抗瘤作用，LAK与IL-2合用比单用LAK效果好，因为经IL-2激活的LAK在输
BNDG－hIL15细胞因子人源化小鼠作用原理
Merry Christmas Everyone，圣诞节到啦，有没有哪位小主想要和小编分享一下你的圣诞大餐呢？作为交换，小编决定和大家分享一下今日的知识源泉--细胞因子人源化小鼠模型 B-NDG hIL15。 利用重度免疫缺陷小鼠通过植入人造血干细胞 HSC（hematopoietic s
IL7－Signal－Transduction
IL-7 is a key cytokine in the immune system, essential for normal development of B cells and T cells. Mice with the IL-7 receptor deleted lack B and T
Complement－Pathway
The complement pathway consists of a series of over thirty proteins in plasma that are part of the immune response. Activation of the complement syste
Prion－Pathway
Transmissible spongiform encephalopathy (TSE) is thought to result from the structural conversion of cellular prion protein, PrP(C), into a misfolded
Glycolysis－Pathway
Glycolysis was one of the first metabolic pathways studied and is one of the best understood, in terms of the enzymes involved, their mechanisms of ac
Fibrinolysis－Pathway
Clot formation and fibrinolysis is a balance of plasmin activation/inhibition and thrombin-thrombomodulin activity that regulates fibrin polymer forma
Antisense－Pathway
About 8% of human genes have been estimated to carry out transcription from both DNA strands, resulting in significant level of endogenous antisense R
Dicer－Pathway
The degradation of endogenous mRNA in a sequence-specific manner can be induced by dsRNA [RNA interfernce (RNAi)], antisense transcription, or viral i
Cadmium－induces－DNA－synthesis－and－proliferation－in－macrophages
Exposure to divalent cadmium ions (Cd2+) is a known cancer risk factor, but the molecular mechanisms responsible for the inappropriate induction of ce
关于白介素2－的作用介绍
1． IL-2对T细胞的作用 IL-2是T细胞生长因子，能使T细胞在试管内长期存活，刺激T细胞进入细胞分裂周期。IL-2能增强T细胞的杀伤活性，在体外它与IL-4、IL-5和IL-6一起共同诱导细胞毒性T细胞（Tc）的产生，并使其活性大大增强，延长其生长期；在体内IL-2也能增强抗原诱导的TC活
研究揭示短形式白介素18的抗肿瘤功能和机制
1月31日，中国科学院上海免疫与感染研究所孟广勋研究组与上海交通大学医学院附属新华医院刘辰莹课题组合作，在《自然-免疫学》（Nature Immunology）上发表了题为Short IL-18 generated by caspase-3 cleavage mobilizes NK cells t
小鼠白细胞介素12抗体（IL12－Ab）酶联免疫分析（ELISA）
小鼠白细胞介素-12抗体（IL-12 Ab）酶联免疫分析（ELISA）试剂盒使用说明书本试剂仅供研究使用 目的：本试剂盒用于测定小鼠血清，血浆及相关液体样本中白细胞介素-12抗体（IL-12 Ab）含量。实验原理： 本试剂盒应用双抗原夹心法测定标本中小鼠白细胞介素-12抗体（IL
淋巴因子激活的杀伤细胞(LAK)
严格来说，LAK细胞并非是一个独立的淋巴群或亚群，而是NK细胞或T细胞体外培养时，在高剂量IL-2等细胞因子诱导下成为能够杀伤NK不敏感肿瘤细胞的杀伤细胞，称为淋巴因子激活的杀伤细胞（lymphokine activated killer cells,LAK)。目前应用LAK细胞过继免疫疗
一文了解nkt细胞免疫治疗
NKT（natural killer T)细胞是一群细胞表面既有T细胞受体TCR，又有NK细胞受体的特殊T细胞亚群。NKT细胞能大量产生细胞因子。NKT细胞表达的是“半恒定的”αβTCR。 NKT细胞能表达T细胞的TCR与NK细胞的NKR-P1两种受体，特别是NKT细胞多数表达Va14TCR，
The－OP9DL1－System:－Generation－of－TLymphocytes－from－Embryonic4
TROUBLESHOOTINGProblem: The OP9 cells are more than 80%-90% confluent.Solution: It is important when creating working stocks of OP9 cells for freezing
Differentiate－ES－cells－into－glial－cells－and－neurons
Day -1: Pass ES cells at normal density on gelatinized plate to free the culture of contamination fibroblast cells.___________________Day 1: Trypsiniz
Culture－of－BEND－Cells－(Bovine－Endometrial－Cells)
Culture of BEND Cells (Bovine Endometrial Cells)Charles E. Krininger, III and Peter J. Hansen Dept. of Animal Sciences, University of FloridaThis prot
人白介素－12（IL12）酶联免疫分析试剂盒使用说明书
人白介素 12（IL-12）酶联免疫分析试剂盒使用说明书 本试剂盒仅供研究使用。 检测范围： 96T 1 ng/L -60 ng/L 使用目的： 本试剂盒用于测定人血清、血浆及相关液体样本中白介素 12（IL-12）含量。 实验原理 本试剂
白介素的作用
对于白介素这个三个字，我想很多人对它都并不是那么的陌生，但是真正了解白介素的能可能就没那么多了，我们今天所要讲的就是关于白介素了，上海elisa生物的技术工作人们为大家总结了白介素的作用有哪些。在没有说到白介素的作用之前，我们就先简单的了解一下白介素，白介素的种类是繁多的，其实白介素是一个减缩的名字
Journal－of－Immunology发布上年度下载量最高的20篇文章
《免疫学杂志》（Journal of Immunology）近日发布了“Top Downloads for 2018”目录。质谱流式技术作为免疫学研究中越来越不可或缺的方法，共有3篇文章名列其中。整理如下：1 文章可说是质谱流式初学者的福音，对数据分析和可视化进行了基础、详尽的描述。 在质谱
IL2－Receptor－Beta－Chain－in－T－cell－Activation
The IL-2 receptor is a key component of immune signaling and is required for the activation, proliferation, and survival of T cells. This receptor is
新一代高效、低毒的肿瘤特异性IL12前体药物
2022年1月7日，Science Immunology在线发表了中国科学院生物物理研究所研究员彭华与美国德克萨斯大学西南医学中心教授傅阳心合作完成的研究论文A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to
关于白细胞介素12的结构功能介绍
结构：IL-12主要由B细胞和巨噬细胞产生；其分子是一种异型二聚体，40KD（p40）和35KD(p35)的2个亚基通过二硫键相连接。 功能：IL-12主要作用于T细胞和NK细胞，曾被命名为细胞毒性淋巴细胞成熟因子（CLMF）和NK细胞刺激因子（NKsf）。IL-12可刺激活化型T细胞增殖，促
mTOR－Signaling－Pathway
mTOR (mammalian target of rapamycin) appears to play a central role in signaling caused by nutrients and mitogens such as growth factors to regulate t
Erythrocyte－Differentiation－Pathway
Stem cells in the bone marrow produce a variety of hematopoietic cell types from common progenitor cells under the influence of cytokines and growth f
MAPKinase－Signaling－Pathway
The ever evolving mitogen-activated protein kinase (MAP kinase) pathways consist of four major groupings and numerous related proteins which constitut
Reelin－Signaling－Pathway
Reelin is an extracellular protein secreted by neurons. Reeler mice with a defective Reelin gene exhibit neuronal abnormalities in development. Mice t
PDGF－Signaling－Pathway
Platelet Derived Growth Factor (PDGF) plays a critical role in cellular proliferation and development. The biologically active form is a dimer formed
BCR－Signaling－Pathway
Significant progress has been made towards delineation of the intrinsic molecular processes that regulate B lymphocyte immune function. Recent observa