SignalingofHepatocyteGrowthFactorReceptor
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutated forms of the HGF receptor are associated with oncogenesis and metastasis, making the HGF receptor a potential therapeutic target for cancer drugs. Changes in cell motility, cell shape, adhesion, resistance to apoptosis, and anchorage independent growth all contribute ......阅读全文
Signaling－of－Hepatocyte－Growth－Factor－Receptor
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutate
Nerve－growth－factor－pathway－(NGF)
Nerve growth factor (NGF) is one of a family of neurotrophins that induce the survival and proliferation of neurons. In cell culture NGF induces the f
Growth－Hormone－Signaling－Pathway
Growth hormone plays a major role in regulating growth during childhood and adolescence and also regulates metabolism. Defects in growth hormone signa
Trka－Receptor－Signaling－Pathway
Nerve growth factor (NGF) is a neurotrophic factor that stimulates neuronal survival and growth through TrkA, a member of the trk family of tyrosine k
T－Cell－Receptor－Signaling－Pathway
The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alph
Msp/Ron－Receptor－Signaling－Pathway
MSP, macrophage-stimulating protein, acts through the transmembrane receptor kinase RON (Stk in mice) to play a role in inflammation and the response
Fc－Epsilon－Receptor－I－Signaling－in－Mast－Cells
The Fc Epsilon Receptor 1 signaling pathway in mast cells uses multiple core signal path to achieve its necessary ends. Through the BTK protein and PK
IL22－Soluble－Receptor－Signaling－Pathway
IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surfa
Growing－Cells－in－Geltrex™－Reduced－Growth－Factor－Basement－Membrane－Matrix
实验概要Basement membranes are continuous sheets of specialized extracellular matrix that form an interface between endothelial, epithelial, muscle, or
酪氨酸激酶的受体型
受体酪氨酸激酶（receptor protein tyrosine kinases，RPTKs）的胞外区是结合配体结构域，配体是可溶性或膜结合的多肽或蛋白类激素，包括胰岛素和多种生长因子。胞内段是酪氨酸蛋白激酶的催化部位，并具有自磷酸化位点。 配体（如EGF）在胞外与受体结合并引起构象变化，导
TGFβ（transforming－growth－factorβ）的功能和作用机制
TGFβ（transforming growth factor-β）是由多种动物细胞合成与分泌、以非活性形式储存在细胞胞外基质中结构相关的信号分子超家族，TGFβ超家族是一类作用广泛、具有多种功能的生长因子，对不同的细胞类型或处于不同状态的同一细胞会引起不同的反应。TGFβ通过具有丝氨酸/苏氨酸激酶
TGFβ（transforming－growth－factorβ）的功能和作用机制
TGFβ（transforming growth factor-β）是由多种动物细胞合成与分泌、以非活性形式储存在细胞胞外基质中结构相关的信号分子超家族，TGFβ超家族是一类作用广泛、具有多种功能的生长因子，对不同的细胞类型或处于不同状态的同一细胞会引起不同的反应。TGFβ通过具有丝氨酸/苏氨酸激酶
IGF1－Signaling－Pathway
Insulin like growth factor 1 (IGF-1) and its receptor (IGF-1R) provide a potent proliferative signaling system that stimulates growth in many differen
Sprouty－regulation－of－tyrosine－kinase－signals
Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors,
CBL－mediated－ligandinduced－downregulation－of－EGF－receptors
As with many cell-surface receptors, activation of the EGF receptor can result in receptor internalization through receptor-mediated endocytosis, dese
Neuroregulin－receptor－degredation－protein1－Controls－ErbB3－receptor
The neuregulins comprise a subfamily of at least four epidermal growth factor (EGF)-like growth factors that influence a variety of cellular events, i
与胃癌相关的SPRY2基因编码功能描述
这个基因编码一种属于芽科的蛋白质。编码蛋白含有一个羧基末端富含半胱氨酸的结构域，对受体酪氨酸激酶信号蛋白的抑制活性至关重要，并且对于生长因子刺激的蛋白质向膜皱褶的易位是必需的。在原发性真皮内皮细胞中，该基因对成纤维细胞生长因子2的反应是短暂上调的。该蛋白间接参与了对成纤维细胞生长因子2信号传导的非细
与肺癌相关的SPRY2基因编码功能描述
这个基因编码一种属于芽科的蛋白质。编码蛋白含有一个羧基末端富含半胱氨酸的结构域，对受体酪氨酸激酶信号蛋白的抑制活性至关重要，并且对于生长因子刺激的蛋白质向膜皱褶的易位是必需的。在原发性真皮内皮细胞中，该基因对成纤维细胞生长因子2的反应是短暂上调的。该蛋白间接参与了对成纤维细胞生长因子2信号传导的非细
SPRY2基因编码的功能和结构描述
这个基因编码一种属于芽科的蛋白质。编码蛋白含有一个羧基末端富含半胱氨酸的结构域，对受体酪氨酸激酶信号蛋白的抑制活性至关重要，并且对于生长因子刺激的蛋白质向膜皱褶的易位是必需的。在原发性真皮内皮细胞中，该基因对成纤维细胞生长因子2的反应是短暂上调的。该蛋白间接参与了对成纤维细胞生长因子2信号传导的非细
SPRY2基因突变因子与药物介绍
这个基因编码一种属于芽科的蛋白质。编码蛋白含有一个羧基末端富含半胱氨酸的结构域，对受体酪氨酸激酶信号蛋白的抑制活性至关重要，并且对于生长因子刺激的蛋白质向膜皱褶的易位是必需的。在原发性真皮内皮细胞中，该基因对成纤维细胞生长因子2的反应是短暂上调的。该蛋白间接参与了对成纤维细胞生长因子2信号传导的非细
GPB7基因编码功能及结构描述
这个基因的产物属于一个小的转接器蛋白家族，已知它与许多受体酪氨酸激酶和信号分子相互作用。该基因编码一种与表皮生长因子受体（EGFR）和肾上腺素受体相互作用的生长因子受体结合蛋白该蛋白通过与粘着斑激酶（FAK）结合在整合素信号通路和细胞迁移中发挥作用已经发现了编码两种不同亚型的转录变体[由RefSeq
GRB7基因编码功能及结构描述
这个基因的产物属于一个小的转接器蛋白家族，已知它与许多受体酪氨酸激酶和信号分子相互作用。该基因编码一种与表皮生长因子受体（EGFR）和肾上腺素受体相互作用的生长因子受体结合蛋白该蛋白通过与粘着斑激酶（FAK）结合在整合素信号通路和细胞迁移中发挥作用已经发现了编码两种不同亚型的转录变体[由RefSeq
GPB7基因突变与药物因子介绍
这个基因的产物属于一个小的转接器蛋白家族，已知它与许多受体酪氨酸激酶和信号分子相互作用。该基因编码一种与表皮生长因子受体（EGFR）和肾上腺素受体相互作用的生长因子受体结合蛋白该蛋白通过与粘着斑激酶（FAK）结合在整合素信号通路和细胞迁移中发挥作用已经发现了编码两种不同亚型的转录变体[由RefSeq
Role－of－ERBB2－in－Signal－Transduction－and－Oncology
Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with the
EGF－Signaling－Pathway
The epidermal growth factor (EGF) peptide induces cellular proliferation through the EGF receptor, which has a tyrosine kinase cytoplasmic domain, a s
VEGF,－Hypoxia,－and－Angiogenesis
Vascular endothelial growth factor (VEGF) plays a key role in physiological blood vessel formation and pathological angiogenesis such as tumor growth
Multiple－antiapoptotic－pathways－from－IGF1R－signaling－lead－to－BAD－phosphory
IGF-1R, the type 1 receptor for insulin-like growth factor, mediates cell survival and growth in response to its ligands IGF-1 and IGF-2. This tyrosin
Role－of－Erk5－in－Neuronal－Survival
Axons extend significant distances to innervate target tissues. At the site of innervation, target tissues release neurotrophins including NGF, BDNF a
GIGYF1基因突变与药物因子介绍
这个基因编码衔接蛋白gyf家族的一个成员编码蛋白包含一个gyf蛋白相互作用域。它结合生长因子受体结合蛋白10，另一种结合激活的胰岛素样生长因子1和胰岛素受体并调节受体信号的衔接蛋白[由RefSeq提供，2017年4月]This gene encodes a member of the gyf fam
GIGYF1基因编码功能及结构描述
这个基因编码衔接蛋白gyf家族的一个成员编码蛋白包含一个gyf蛋白相互作用域。它结合生长因子受体结合蛋白10，另一种结合激活的胰岛素样生长因子1和胰岛素受体并调节受体信号的衔接蛋白[由RefSeq提供，2017年4月]This gene encodes a member of the gyf fam