RoleofEGFReceptorTransactivationbyGPCRsinCardiacHypertrophy
One of responses to increased blood pressure is cardiac hypertrophy through increased size of ventricular myocardial cells leading to increased thickness of the ventricular walls. Cardiac hypertrophy allows the heart to handle the increased stress caused by elevated blood pressure but is also a risk factor associated with heart disease. Cardiac hypertrophy results from cross-talk between G-protein coupled receptor si......阅读全文
Role－of－EGF－Receptor－Transactivation－by－GPCRs－in－Cardiac－Hypertrophy
One of responses to increased blood pressure is cardiac hypertrophy through increased size of ventricular myocardial cells leading to increased thickn
Bioactive－Peptide－Induced－Signaling－Pathway
Many different peptides act as signaling molecules, including the proinflammatory peptide bradykinin, the protease enzyme thrombin, and the blood pres
NFAT－and－Hypertrophy－of－the－heart－(Transcription－in－the－broken－heart)
Hypertrophy associated with both hypertension and obstruction to ventricular outflow leads to pathologic cardiac growth and it is associated with incr
无创血压计应用论文：动物用血压计（五）
FIG. 4.Aberrant gene expression patterns of cardiac remodeling factors in ARKO male mice with or without Ang II stimulation. The left panel demons
无创血压计应用论文：动物用血压计（一）
Androgen Receptor Gene Knockout Male Mice Exhibit Impaired Cardiac Growth and Exacerbation of Angiotensin II-induced Cardiac Fibrosis 【摘要】 Androg
无创血压计应用论文：动物用血压计（四）
Ang II-stimulated Cardiac Dysfunction in ARKO Male Mice-We also evaluated the cardiac performance of these mice using echocardiography. Although l
Neuroregulin－receptor－degredation－protein1－Controls－ErbB3－receptor
The neuregulins comprise a subfamily of at least four epidermal growth factor (EGF)-like growth factors that influence a variety of cellular events, i
arrestins－in－GPCR－Desensitization
Role of ?-arrestins in the desensitization, sequestration and intracellular trafficking of GPCRs. Homologous desensitization of GPCRs (1) results from
Corticosteroids－and－cardioprotection
Myocardial infarction damages heart tissue both during the initial ischemia and the subsequent reperfusion of tissues with oxygen. Corticosteroids can
CBL－mediated－ligandinduced－downregulation－of－EGF－receptors
As with many cell-surface receptors, activation of the EGF receptor can result in receptor internalization through receptor-mediated endocytosis, dese
ALK－in－cardiac－myocytes
Heart formation is cued by a combination of positive and negative signals from surrounding tissues. Inhibitory signals that block heart formation in a
无创血压计应用论文：动物用血压计（三）
TABLE IPrimer sequences for mRNA analyses Sequences are listed 5' to 3'.Quantitative Real-time PCR by SYBR Green Detection Method-The mRNA l
Hop－Pathway－in－Cardiac－Development
Homeodomain transcription factors comprise a large family of DNA binding factors that regulate transcription and development. Many homeodomain genes a
Aspirin－Blocks－Signaling－Pathway－Involved－in－Platelet－Activation
Activation of the protease-activated GPCRs in platelets contributes to platelet activation in clotting. The protease-activated receptors PAR1 and PAR4
GMEB1基因编码功能及结构描述
该基因编码一个与gmeb2蛋白相关的kdwk基因家族成员。gmeb1-gmeb2复合物是细小病毒dna复制的关键。在大鼠体内对类似基因的研究表明，该基因的作用是调节糖皮质激素受体与糖皮质激素反应元件结合时的反式激活。存在三种不同编码亚型的剪接转录变体。[由RefSeq提供，2016年2月]This
GMEB1基因突变与药物因子介绍
该基因编码一个与gmeb2蛋白相关的kdwk基因家族成员。gmeb1-gmeb2复合物是细小病毒dna复制的关键。在大鼠体内对类似基因的研究表明，该基因的作用是调节糖皮质激素受体与糖皮质激素反应元件结合时的反式激活。存在三种不同编码亚型的剪接转录变体。[由RefSeq提供，2016年2月]This
GMEB1基因编码功能及结构描述
该基因编码一个与gmeb2蛋白相关的kdwk基因家族成员。gmeb1-gmeb2复合物是细小病毒dna复制的关键。在大鼠体内对类似基因的研究表明，该基因的作用是调节糖皮质激素受体与糖皮质激素反应元件结合时的反式激活。存在三种不同编码亚型的剪接转录变体。[由RefSeq提供，2016年2月]This
Differentiate－ES－cells－into－cardiac－myocytes
Day -1: Pass ES cells at normal density on gelatinized plate to free the culture of contamination fibroblast cells.____________________Day 1: Trypsini
Primary－cardiac－fibroblast－and－cardiomyocyte－isolation
1. Ventricles were removed under sterile conditions. 2. Ventricles were placed in cold sterile primary cell culture medium, minced into approximat
Isolation－of－rat－cardiac－fibroblasts－and－cardiomyocytes
1. Hearts were removed from newborn rats (day 0), put into calcium- and bicarbonate-free HEPES-buffered Hanks’ medium, cut into pieces and digeste
ECSCR基因编码功能及结构描述
该基因编码的蛋白质主要存在于内皮细胞和血管中，参与细胞形态变化和表皮生长因子诱导的细胞迁移。能增强血管内皮生长因子受体-2/激酶插入结构域受体的活化，并促进内化激酶插入结构域受体的蛋白水解。该基因可能在血管生成相关疾病中发挥作用。选择性剪接导致多个转录变体。The protein encoded b
ECSCR基因突变与药物因子介绍
该基因编码的蛋白质主要存在于内皮细胞和血管中，参与细胞形态变化和表皮生长因子诱导的细胞迁移。能增强血管内皮生长因子受体-2/激酶插入结构域受体的活化，并促进内化激酶插入结构域受体的蛋白水解。该基因可能在血管生成相关疾病中发挥作用。选择性剪接导致多个转录变体。The protein encoded b
Eph－Kinases－and－ephrins－support－platelet－aggregation
Eph kinases are a family of receptor tyrosine kinases with an extracellular domain that binds their ligand, the ephrins, and an intracellular kinase d
Pertussis－toxininsensitive－CCR5－Signaling－in－Macrophage
The chemokine receptors CCR5 and CXCR4 in macrophages are activated by their peptide ligands and also by the HIV envelope protein GP120 during HIV inf
Role－of－Mitochondria－in－Apoptotic－Signaling
Mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein
Control－of－skeletal－myogenesis－by－HDAC－calcium/calmodulindependent－kinase
The differentiation of muscle cells is transcriptionally regulated, in part by the myocyte enhancer factor-2, MEF2. During myogenesis MEF2 binds to My
EGF－Signaling－Pathway
The epidermal growth factor (EGF) peptide induces cellular proliferation through the EGF receptor, which has a tyrosine kinase cytoplasmic domain, a s
Trka－Receptor－Signaling－Pathway
Nerve growth factor (NGF) is a neurotrophic factor that stimulates neuronal survival and growth through TrkA, a member of the trk family of tyrosine k
B－Cell－Receptor－Complex
B cells produce immunoglobulins (Ig, antibodies) that specifically bind antigen molecules. B cells first produce a membrane-bound form of immunoglobul
Chromatin－Remodeling－by－hSWI/SNF－ATPdependent－Complexes
The eukaryotic genome is packaged by histone and nonhistone proteins to form chromatin. The assembly of nucleosomesas well as compaction of nucleosoma