AngiotensinIImediatedactivationofJNKPathwayviaPyk2dependent
Ang II binding to AT1-R triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to the Pyk2 and further to the small G protein Rac1 but not Cdc42, although the direct activation of Rac1 by Pyk2 is not proved in this study. In turn, Rac1 activates a small G protein-activated kinase whose identity is still controversial, but one of which has been suggested to be PAK1. Finally, the JNK cascade,......阅读全文
RasIndependent－pathway－in－NK－cellmediated－cytotoxicity
NK (natural killer) cells are lymphocytes distinct from B and T cells that induce perforin-mediated lysis of tumor cells and virus-infected cells. NK
无创血压计应用论文：动物用血压计（五）
FIG. 4.Aberrant gene expression patterns of cardiac remodeling factors in ARKO male mice with or without Ang II stimulation. The left panel demons
无创血压计应用论文：动物用血压计（一）
Androgen Receptor Gene Knockout Male Mice Exhibit Impaired Cardiac Growth and Exacerbation of Angiotensin II-induced Cardiac Fibrosis 【摘要】 Androg
Inactivation－of－Gsk3－by－AKT－causes－accumulation－of－bcatenin
Lipopolysaccharide (LPS) from XX bacteria induces a wide range of inflammatory responses, including the response of alveolar macrophages to bacteria i
RhoSelective－Guanine－Exchange－FactorAKAP13－Mediates－Stress－Fiber－Formation
The A-kinase anchor protein 13 (AKAP13, also known as AKAP-LBC) is one of a group of structurally diverse proteins, which have the common function of
IL12－and－Stat4－Dependent－Signaling－Pathway－in－Th1－Development
Interleukin-12 (IL-12) promotes cell-mediated immunity by inducing Th1 cell differentiation and activation of both T cells and NK cells. Dendritic cel
Role－of－arrestins－in－the－activation－and－targeting－of－MAP－kinases
The binding of ?-arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kinase activation complex using ?-arrestin as a scaffold, with sub
Regulation－of－cell－cycle－progression－by－Plk3
The focus of this pathway is to illustrate the role of Polo-like Kinase 3 (Plk3 also known as Prk and Fnk) as part of the regulatory cascade leading t
GADD34mediated－Dephosphorylatoin－of－eIF2a－in－Stress－Response－Pathway
NON-Clickable Image Translation initiation is inhibited in cells exposed to different stressful conditions. The phosphorylation of the aContributor:RE
山羊抗兔二抗（HRP标记）在诸多文献中的应用
在免疫学实验中，比如WB，IHC，IF等，大家都知道选着好正确的一抗，往往实验就成功了一大半，因此，往往很多研究者便会忽视对二抗，以及其它试剂盒品质的追求。二抗是一种相对而言比较稳定的产品，包装大，因此很多实验室都会公用一个二抗。但如果二抗没有选择好的话，影响的可能就是一整个实验室或者课题组了。艾美
Hypoxia－and－p53－in－the－Cardiovascular－system
Hypoxic stress, like DNA damage, induces p53 protein accumulation and p53-dependent apoptosis in oncogenically transformed cells. Unlike DNA damage, h
血液肿瘤常用体内外模型总结工具病毒使用指南（二）
二、细胞实验效果不错，那动物实验怎么做？稳定性、重复性较好的动物模型可在肿瘤基础性研究和抗肿瘤药物筛选中发挥重要作用。血液肿瘤常用的动物模型主要有：I皮下移植瘤模型；II血液模型。皮下移植瘤模型较容易建立，易于动态观察肿瘤的生长状态。血液模型则一般以生存天数作为观察终点，用活体成像、病理切片、流式细
Oxidative－Stress－Induced－Gene－Expression－Via－Nrf2
Reactive oxygen species (ROS) can damage biological macromolecules and are detrimental to cellular health. Electrophilic compounds, xenobiotics and an
HIVI－Nef:－negative－effector－of－Fas－and－TNF
HIV infection leads to drastic declines in CD4 T helper cells, in part through apoptosis of uninfected cells. Apoptosis of uninfected cells may be ind
Role－of－Erk5－in－Neuronal－Survival
Axons extend significant distances to innervate target tissues. At the site of innervation, target tissues release neurotrophins including NGF, BDNF a
Regulation－of－Spermatogenesis－by－CREM
The transcriptional regulator CREM plays a key role in spermatogenesis, acting as a central transcription factor triggering a cascade of transcription
Phosphorylation－of－MEK1－by－cdk5/p35－down－regulates－the－MAP－kinase－pathway
Map kinases transduce responses to extracellular signals by a variety of routes, and communicate with other pathways through extensive crosstalk netwo
Signal－transduction－through－IL1R
Interleukin-1 (IL-1) is a pro-inflammatory cytokine that signals primarily through the type 1 IL-1 receptor (IL-1R1). The activities of IL-1 include i
狗血管紧张素II(Angiotensin2)ELISA检测法
狗血管紧张素II(Angiotensin-2)ELISA试剂盒 (用于血清、血浆、细胞培养上清液和其它生物体液内) 原理本实验采用双抗体夹心 ABC-ELISA法。用抗狗 Angiotensin-2 单抗包被于酶标板上，标准品和样品中的 Angiotensin-2与单抗结合，加入生物素化的抗狗Ang
大鼠血管紧张素II(Angiotensin2)ELISA检测法
大鼠血管紧张素II(Angiotensin-2)ELISA试剂盒 (用于血清、血浆、细胞培养上清液和其它生物体液内)原理本实验采用双抗体夹心 ABC-ELISA法。用抗大鼠 Angiotensin-2 单抗包被于酶标板上，标准品和样品中的 Angiotensin-2与单抗结合，加入生物素化的抗大鼠A
Actions－of－Nitric－Oxide－in－the－Heart
Nitric oxide (NO) has a number of important physiological actions in the cardiovascular system. In the heart, NO plays role in keeping the vessels pat
Chaperones－modulate－interferon－Signaling－Pathway
Signaling by interferon-gamma stimulates anti-viral responses and tumor suppression through the heterodimeric interferon-gamma receptor. Signaling is
Bioactive－Peptide－Induced－Signaling－Pathway
Many different peptides act as signaling molecules, including the proinflammatory peptide bradykinin, the protease enzyme thrombin, and the blood pres
Ion－Channels－and－Their－Functional－Role－in－Vascular－Endothelium
Endothelial cells (EC) form a multifunctional signal-transducing surface that performs different tasks dependent on its localization in the vessel tre
昆明植物所抗肿瘤药物研究取得进展
环吡酮胺（ciclopirox，CPX）作为广谱抗真菌药，在近年的研究中发现该化合物具有较好的体内外抗肿瘤作用，并显示出重要的抗肿瘤药物成药潜力。机制研究显示，CPX 抗肿瘤作用与细胞内多个重要信号通路，如 mTOR、wnt 等，以及螯合细胞内 Fe2+ 离子从而抑制 Fe2+ 依赖的核苷酸还原
小鼠血管紧张素II(Angiotensin2)ELISA试剂盒
小鼠血管紧张素II(Angiotensin-2)ELISA试剂盒 (用于血清、血浆、细胞培养上清液和其它生物体液内) 原理本实验采用双抗体夹心 ABC-ELISA法。用抗小鼠 Angiotensin-2 单抗包被于酶标板上，标准品和样品中的 Angiotensin-2与单抗结合，加入生物素化的抗小鼠
兔血管紧张素II(Angiotensin2)ELISA试剂盒
兔血管紧张素II(Angiotensin-2)ELISA试剂盒 (用于血清、血浆、细胞培养上清液和其它生物体液内) 原理本实验采用双抗体夹心 ABC-ELISA法。用抗兔 Angiotensin-2 单抗包被于酶标板上，标准品和样品中的 Angiotensin-2与单抗结合，加入生物素化的抗兔Ang
人血管紧张素II(Angiotensin2)ELISA试剂盒
人血管紧张素II(Angiotensin-2)ELISA试剂盒 (用于血清、血浆、细胞培养上清液和其它生物体液内) 原理本实验采用双抗体夹心 ABC-ELISA法。用抗人 Angiotensin-2 单抗包被于酶标板上，标准品和样品中的 Angiotensin-2与单抗结合，加入生物素化的抗人Ang
猪血管紧张素II(Angiotensin2)ELISA试剂盒
猪血管紧张素II(Angiotensin-2)ELISA试剂盒 (用于血清、血浆、细胞培养上清液和其它生物体液内) 原理本实验采用双抗体夹心 ABC-ELISA法。用抗猪 Angiotensin-2 单抗包被于酶标板上，标准品和样品中的 Angiotensin-2与单抗结合，加入生物素化的抗猪Ang
中山大学最新《Blood》文章解析细胞因子新发现
郑利民 教授 1984年毕业于上海医科大学后在附属华山医院任临床医生，94年获荷兰莱顿（Leiden）大学细胞生物和免疫学博士学位，1999年获瑞典国家研究院人才基金（助理教授）资助而在瑞典林雪平大学建立了独立的实验室。2002年被聘为中山大学教授，博士导师。现任中山大学生命科学院生物化学系主