ApoptoticSignalinginResponsetoDNADamage
The cellular activation of the caspase cascade resulting in cell death is triggered by chemical damage to DNA which stimulates a sequence resulting in the cleavage of Bid in a manner similar to the binding of so called “death-receptors” or directly initiates the permeability transition of the mitochondrial membrane. The permiability transition releases several factors including cytochrome c, AIF and other factors in ......阅读全文
NOD1基因编码功能及结构描述
该基因编码核苷酸结合寡聚结构域（nod）样受体（nlr）家族的一个成员。编码蛋白作为结合细菌肽聚糖并引发炎症的模式识别受体（prr）在先天免疫中发挥作用。这种蛋白质也与病毒和寄生虫感染的免疫反应有关。该蛋白的主要结构特征包括一个n端caspase募集域（card）、一个中心定位的核苷酸结合域（nbd
RPA4基因突变因子与药物介绍
这个基因编码一个单链dna结合蛋白，它是复制蛋白a复合物的30kda亚单位。复制蛋白a是dna双链断裂修复和细胞周期检测点激活的重要因子。编码蛋白定位于DNA修复灶，可能参与细胞DNA损伤反应这种蛋白质也可能在抑制病毒复制方面发挥作用This gene encodes a single-strand
MicroRNA－Expression－Profiling－by－Bead－Array－1
MicroRNA Expression Profiling by Bead Array Technology in Human Tumor Cell Lines Treated with Interferon-Alpha-2aMicroRNAs are positive and negative r
Stress－Induction－of－HSP－Regulation
Mammalian cells can respond to a variety of stresses such as heat, cold, oxidative stress, metabolic disturbance, and environmental toxins through nec
IFN－alpha－signaling－pathway
Interferon alpha plays a role in viral infections. Signaling takes place through an IFN Recpetor complex consisting of two alpha chains (Type I recept
IL－3－signaling－pathway
Interleukin-3 promotes the proliferation and differentiation of hematopoietic cells through binding to its receptor. The receptor for IL-3 is a hetero
TNF/Stress－Related－Signaling
TNF acts on several different signaling pathways through two cell surface receptors, TNFR1 and TNFR2 (See TNFR1 and TNFR2 Signaling Pathways) to regul
IL－6－signaling－pathway
Interleukin-6 (IL-6) is a cytokine that provokes a broad range of cellular and physiological responses. In addition to playing a role in inflammation
Proteolysis－and－Signaling－Pathway－of－Notch
Notch is a large cell-surface receptor that is activated by contact with membrane-bound ligands on neighboring cells. The ligands that activate Notch
IL－2－signaling－pathway
Interleukin 2 (IL-2) is a potent cytokine that can lead to cellular activation and proliferation. IL-2 Receptors are found on activated B-Cells, LPS t
Trka－Receptor－Signaling－Pathway
Nerve growth factor (NGF) is a neurotrophic factor that stimulates neuronal survival and growth through TrkA, a member of the trk family of tyrosine k
Cell－to－Cell－Adhesion－Signaling
Interactions between cells responsible for cell to cell adhesion also can communicate signals into the cellular interior, often involving interactions
Nitric－Oxide－Signaling－Pathway
Glutamatergic-mediated nitric oxide (NO) production occurs via the N-methyl-D-aspartic acid (NMDA) postsynaptic density protein 95 (PSD95)-neuronal ni
IL－17－Signaling－Pathway
Inflammation is a complex response involving many different cells and signaling molecules, including the secretion of the cytokine IL-17 by activated
IL－4－signaling－pathway
Interleukin 4 (IL-4) is a cytokine that can lead to development of Th2 cells. The 140 kD IL-4 Receptor (CD124) is found on many cell types, even those
IFN－gamma－signaling－pathway
Interferon gamma is secreted from CD4+ Th1 cells, CD8 cells, gamma/delta T cells and activated NK cells. It plays a role in activating lymphocytes to
IL－18－Signaling－Pathway
IL-18 is a pro-inflammatory cytokine similar in structure and mechanism of action to IL-1 beta. Formation of active IL-18 by macrophages requires clea
Phospholipase－C－Signaling－Pathway
Phospholipase C comes in multiple forms and plays a key role in the signal transduction process for many receptors. Its main function is to hydrolyze
TGF－beta－signaling－pathway
TGF-beta regulates growth and proliferation of cells, blocking growth of many cell types. The TGF-beta receptor includes type 1 and type 2 subunits th
Growth－Hormone－Signaling－Pathway
Growth hormone plays a major role in regulating growth during childhood and adolescence and also regulates metabolism. Defects in growth hormone signa
细胞凋亡信号通路相关基因介绍ATR
该基因编码的蛋白属于PI3/PI4激酶家族，与ATM（一种在共济失调性毛细血管扩张症中突变的基因编码的蛋白激酶）关系最为密切。这种蛋白和atm与pombe-rad3裂殖酵母菌（schizosaccharomyces pombe rad3）具有相似性，后者是细胞周期停滞和DNA损伤修复反应中所需的细胞
ATR正相关基因编码功能描述
该基因编码的蛋白属于PI3/PI4激酶家族，与ATM（一种在共济失调性毛细血管扩张症中突变的基因编码的蛋白激酶）关系最为密切。这种蛋白和atm与pombe-rad3裂殖酵母菌（schizosaccharomyces pombe rad3）具有相似性，后者是细胞周期停滞和DNA损伤修复反应中所需的细胞
实体肿瘤检测ATR基因介绍
该基因编码的蛋白属于PI3/PI4激酶家族，与ATM（一种在共济失调性毛细血管扩张症中突变的基因编码的蛋白激酶）关系最为密切。这种蛋白和atm与pombe-rad3裂殖酵母菌（schizosaccharomyces pombe rad3）具有相似性，后者是细胞周期停滞和DNA损伤修复反应中所需的细胞
细胞周期信号通路相关ATR
该基因编码的蛋白属于PI3/PI4激酶家族，与ATM（一种在共济失调性毛细血管扩张症中突变的基因编码的蛋白激酶）关系最为密切。这种蛋白和atm与pombe-rad3裂殖酵母菌（schizosaccharomyces pombe rad3）具有相似性，后者是细胞周期停滞和DNA损伤修复反应中所需的细胞
ATR基因突变与药物因子介绍
该基因编码的蛋白属于PI3/PI4激酶家族，与ATM（一种在共济失调性毛细血管扩张症中突变的基因编码的蛋白激酶）关系最为密切。这种蛋白和atm与pombe-rad3裂殖酵母菌（schizosaccharomyces pombe rad3）具有相似性，后者是细胞周期停滞和DNA损伤修复反应中所需的细胞
与细胞周期信号通路相关因子介绍ATR
该基因编码的蛋白属于PI3/PI4激酶家族，与ATM（一种在共济失调性毛细血管扩张症中突变的基因编码的蛋白激酶）关系最为密切。这种蛋白和atm与pombe-rad3裂殖酵母菌（schizosaccharomyces pombe rad3）具有相似性，后者是细胞周期停滞和DNA损伤修复反应中所需的细胞
ATR基因编码功能及结构描述
该基因编码的蛋白属于PI3/PI4激酶家族，与ATM（一种在共济失调性毛细血管扩张症中突变的基因编码的蛋白激酶）关系最为密切。这种蛋白和atm与pombe-rad3裂殖酵母菌（schizosaccharomyces pombe rad3）具有相似性，后者是细胞周期停滞和DNA损伤修复反应中所需的细胞
DNA损伤修复信号通路相关因子ATR
该基因编码的蛋白属于PI3/PI4激酶家族，与ATM（一种在共济失调性毛细血管扩张症中突变的基因编码的蛋白激酶）关系最为密切。这种蛋白和atm与pombe-rad3裂殖酵母菌（schizosaccharomyces pombe rad3）具有相似性，后者是细胞周期停滞和DNA损伤修复反应中所需的细胞
与细胞凋亡信号通路相关因子介绍ATR
该基因编码的蛋白属于PI3/PI4激酶家族，与ATM（一种在共济失调性毛细血管扩张症中突变的基因编码的蛋白激酶）关系最为密切。这种蛋白和atm与pombe-rad3裂殖酵母菌（schizosaccharomyces pombe rad3）具有相似性，后者是细胞周期停滞和DNA损伤修复反应中所需的细胞
DNA修复机制的分子机理
当DNA双链发生断裂时，细胞启动DNA破坏反应（DNA-damage response, DDR）。DDR的一个重要方面是被破坏的DNA位点的信号的反馈和修复因子的聚集。这项研究表明，在高等的真核生物中，DDR机制中向双链破坏位点不断的积聚作用依赖于组蛋白变体（histone varia