Interleukin6InducedAcutePhenotypicMicroenvironmentPromote...（十）
In this study, we found that “acute” response was strongly induced by cryo-thermal therapy with “acute” and high expression of a series of acute phase proteins and consequently reverse the tumor chronic pro-tumorigenic environment. “Acute’ response is generally occurred as an immediate and evident inflammation in response to stress. In tumor progress, chronic environment is often induced with little visib......阅读全文
Interleukin6－Induced－Acute－Phenotypic－Microenvironment－Promote...（十）
In this study, we found that “acute” response was strongly induced by cryo-thermal therapy with “acute” and high expression of a series of acute p
Interleukin6－Induced－Acute－Phenotypic－Microenvironment－Promote...（二）
As a primary component of circulatory system, serum is the major reservoir of thousands of proteins secreted or “leaked” from a broad spectrum of
Interleukin6－Induced－Acute－Phenotypic－Microenvironment－Promote...（三）
Target analysis by Parallel reaction monitoring (PRM)The targeted quantification and verification were carried out in 94 serum samples with 5~6 mic
Interleukin6－Induced－Acute－Phenotypic－Microenvironment－Promote...（四）
Flow cytometrySpleens were extracted after therapy and mechanically homogenized with gentle MACS Dissociator to obtain a single-cell splenocyte su
Interleukin6－Induced－Acute－Phenotypic－Microenvironment－Promote...（一）
Interleukin-6 Induced Acute Phenotypic Microenvironment Promotes Th1 Anti-Tumor ImmunityTing Xue1, Ping Liu1, Yong Zhou2, Kun Liu1, Li Yang2, Robert L
Interleukin6－Induced－Acute－Phenotypic－Microenvironment－Promote...（六）
Cryo-thermal therapy induced an “acute” phase response First, we performed PRM analysis upon significant proteins involved in acute phase response,
Interleukin6－Induced－Acute－Phenotypic－Microenvironment－Promote...（八）
In summary, we suggested that “acute” response could elicit innate and Th1 adaptive immunity, reversing the tumor-mediated immunosuppressive envir
Interleukin6－Induced－Acute－Phenotypic－Microenvironment－Promote...（七）
Figure 7. The expression of three acute phase proteins after IL-6 neutralization. Mice were injected intraperitoneally with mouse anti-IL-6 Ab 3 and
Interleukin6－Induced－Acute－Phenotypic－Microenvironment－Promote...（五）
Figure 2. Proteomics analysis of serum glycoproteins from treated and untreated mice. 21 days after cell injection, mice underwent cryo-thermal or
Interleukin6－Induced－Acute－Phenotypic－Microenvironment－Promote...（九）
The strongest and unique “acute” environment induced by cryo-thermal therapy stimulated the most effective anti-tumor immune response As described
Interleukin6－Induced－Acute－Phenotypic－Microenvironment－Prom...（十一）
ConclusionIn summary, using comprehensive discovery proteomics analysis followed by target proteomics validation at a large scale sample size, we
Interleukin6－Induced－Acute－Phenotypic－Microenvironment－Prom...（十二）
References1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA: a cancer journal for clinician
Developmental－and－phenotypic－implications－of－transplantation
ObjectiveIn this experiment, a region of the neural crest will be transplanted from one stage-fourteen embryo to another (Figure 1). To facilitate the
Lectin－Induced－Complement－Pathway
The complement cascade of proteolytic factors involved in cellular lysis can be initiated by several different factors, including antibody-dependent a
Free－Radical－Induced－Apoptosis
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Chloroplast－Phenomics:－Systematic－Phenotypic－Screening－of－Chloroplast－...
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HIV－Induced－T－Cell－Apoptosis
HIV infection is associated with immunosuppression caused by a dramatic reduction in the helper T cell population. The loss of helper T cells may be c
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Inflammation has several distinct components, including the localized response at the site of tissue injury or infection. Tissue injury stimulates the
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Objective:The purpose of this experiment was to explore the effects of the growth factors bFGF and VEGF on blood vessel formation within the chorioall
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As with many cell-surface receptors, activation of the EGF receptor can result in receptor internalization through receptor-mediated endocytosis, dese
TSP1－Induced－Apoptosis－in－Microvascular－Endothelial－Cell
As tissues grow they require angiogenesis to occur if they are to be supplied with blood vessels and survive. Factors that inhibit angiogenesis might
siRNAs结合生物芯片的实验设计1
Ambion and Applied Biosystems have joined forces to provide a complete convenient, solution for performing gene silencing experiments and validating t
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Neutrophils respond to bacterial infection by releasing reactive oxygen species that kill bacteria and by expressing chemokines that attract other imm
Oxidative－Stress－Induced－Gene－Expression－Via－Nrf2
Reactive oxygen species (ROS) can damage biological macromolecules and are detrimental to cellular health. Electrophilic compounds, xenobiotics and an
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2006年日本京都大学山中伸弥领导的实验室在世界著名学术杂志《细胞》上率先报道了诱导多能干细胞（Induced Pluripotent Stem cells，iPS）的研究。他们把Oct3/4、Sox2、c-Myc和Klf4这4种转录因子引入小鼠胚胎或皮肤纤维母细胞，发现可诱导其发生转化，产
RNAinduced－silencing－complex（RISC）的功能和用途
RNA-induced silencing complex（RISC）：一种RNA-蛋白质复合物，通过与目标mRNA完全或者部分的互补配对来实施切割或者翻译抑制功能。SiRNA组装siRISC，miRNA组装miRISC。RISCs（无论siRISC还是miRISC）包括两种类型：切割型和不切割型。
Dynamic－Monitoring－ofCellular－Remodeling－Induced－bythe－Transforming－Growth2
Results and discussionData acquisition demonstrated a linear increasing of the CI values in control cells during the time interval observed. However,
Dynamic－Monitoring－ofCellular－Remodeling－Induced－bythe－Transforming－Growth2
Results and discussionData acquisition demonstrated a linear increasing of the CI values in control cells during the time interval observed. However,