PhospholipaseCepsilonpathway
Proposed model for b2-AR- and prostanoid-receptor-mediated PLC and calcium signalling. Receptors coupling to Gs stimulate AC, resulting in elevated cAMP levels and activation of Epac1. Epac1 then catalyses GTP-loading on Rap2B, which leads to PLC-e activation. The proposed pathway may involve additional signalling components to attain PLC stimulation.The action of cAMP seems to be independent of PKA; Instead, the cAM......阅读全文
Phospholipase－Cepsilon－pathway
Proposed model for b2-AR- and prostanoid-receptor-mediated PLC and calcium signalling. Receptors coupling to Gs stimulate AC, resulting in elevated cA
Phospholipase－C－Signaling－Pathway
Phospholipase C comes in multiple forms and plays a key role in the signal transduction process for many receptors. Its main function is to hydrolyze
Assay－of－Phospholipase－A－Activity
Phospholipases of the A type constitute a large family of esterases that catalyze the hydrolysis of the fatty acid ester bonds in phospholipids an
Antisense－Pathway
About 8% of human genes have been estimated to carry out transcription from both DNA strands, resulting in significant level of endogenous antisense R
Complement－Pathway
The complement pathway consists of a series of over thirty proteins in plasma that are part of the immune response. Activation of the complement syste
Prion－Pathway
Transmissible spongiform encephalopathy (TSE) is thought to result from the structural conversion of cellular prion protein, PrP(C), into a misfolded
Fibrinolysis－Pathway
Clot formation and fibrinolysis is a balance of plasmin activation/inhibition and thrombin-thrombomodulin activity that regulates fibrin polymer forma
Glycolysis－Pathway
Glycolysis was one of the first metabolic pathways studied and is one of the best understood, in terms of the enzymes involved, their mechanisms of ac
Dicer－Pathway
The degradation of endogenous mRNA in a sequence-specific manner can be induced by dsRNA [RNA interfernce (RNAi)], antisense transcription, or viral i
Phospholipase－C－d1－in－phospholipid－associated－cell－signaling
Phospholipase C (PLC) d1 is a member of the PLC family that produces two second messengers, diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3)
WNT－Signaling－Pathway
Wnt family members are secreted glycoproteins who bind to cell surface receptors such as Frizzled. Wnt members can play a role in the expression of ma
TPO－Signaling－Pathway
Thrombopoietin (TPO) binds to its receptor inducing aggregation and activation. TPO signals its growth regulating effects to the cell through several
BCR－Signaling－Pathway
Significant progress has been made towards delineation of the intrinsic molecular processes that regulate B lymphocyte immune function. Recent observa
Ceramide－Signaling－Pathway
Over 1,000 papers and reviews have been written about the role of ceramide in the production of programmed cell death or apoptosis. Ceramide is a sphi
AKT－Signaling－Pathway
Many cell-surface receptors induce production of second messengers like PIP3, phosphatidylinositol 3,4,5-trisphosphate, that convey signals to the cyt
Integrin－Signaling－Pathway
Integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals in response to the extracellular ma
EGF－Signaling－Pathway
The epidermal growth factor (EGF) peptide induces cellular proliferation through the EGF receptor, which has a tyrosine kinase cytoplasmic domain, a s
ATM－Signaling－Pathway
The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to
EPO－Signaling－Pathway
Erythropoietin functions to increase the number of red blood cells. Thus, it has found utility as a drug for those needing to replenish erythrocytes f
Reelin－Signaling－Pathway
Reelin is an extracellular protein secreted by neurons. Reeler mice with a defective Reelin gene exhibit neuronal abnormalities in development. Mice t
Insulin－Signaling－Pathway
The appropriate signaling through the insulin pathway is critical for the regulation of glucose levels and the avoidance of diabetes. Insulin forms a
MAPKinase－Signaling－Pathway
The ever evolving mitogen-activated protein kinase (MAP kinase) pathways consist of four major groupings and numerous related proteins which constitut
PDGF－Signaling－Pathway
Platelet Derived Growth Factor (PDGF) plays a critical role in cellular proliferation and development. The biologically active form is a dimer formed
Phosphatidylcholine－Biosynthesis－Pathway
The main components of biological membranes are phosphoglyceride lipids composed of a glycerol unit esterified to two fatty acids and a polar alcohol
Classical－Complement－Pathway
The complement system is part of the defense against invading cells and is composed of about twenty different proteins found in the plasma. When activ
Erythrocyte－Differentiation－Pathway
Stem cells in the bone marrow produce a variety of hematopoietic cell types from common progenitor cells under the influence of cytokines and growth f
mTOR－Signaling－Pathway
mTOR (mammalian target of rapamycin) appears to play a central role in signaling caused by nutrients and mitogens such as growth factors to regulate t
Ras－Signaling－Pathway
Ras activates many signaling cascades. Here we illustrate some of the well-characterized cascades in a generic compilation of effector molecules. The
Alternative－Complement－Pathway
The complement system of plasma proteins is an important part of the immune system that forms a cascade of factors that lyses foreign cells. There are
Nerve－growth－factor－pathway－(NGF)
Nerve growth factor (NGF) is one of a family of neurotrophins that induce the survival and proliferation of neurons. In cell culture NGF induces the f