RegulatorsofBoneMineralization
Osteoblasts mineralize bone matrix by promoting hydroxyapatite crystal formation and growth in the interior of membrane-limited matrix vesicles (MVs) and by propagating the crystals onto the collagenous extracellular matrix. Two osteoblast proteins, tissue-nonspecific alkaline phosphatase (TNAP) and plasma cell membrane glycoprotein-1 (PC-1) are involved in this process. Schematic representation of the counterregulat......阅读全文
Regulators-of-Bone-Mineralization
Osteoblasts mineralize bone matrix by promoting hydroxyapatite crystal formation and growth in the interior of membrane-limited matrix vesicles (MVs)
Bone-Remodelling
Bone density and structure is maintained through a balance of bone resorption by osteoclasts and bone deposition by osteoblasts. The combination of si
Isolation-of-bone-marrow
(contributed by Chris Jackson (chris.jackson@bris.ac.uk))A protocol I have used to isolate rat bone marrow is: 1. Kill the rat and dissect out the fem
LRRK1基因编码功能及结构描述
该基因编码一个富含亮氨酸的重复激酶和一个GDP/GTP结合蛋白的多结构域蛋白。编码的蛋白质被认为在调节骨量中起作用缺乏相似基因的小鼠表现出严重的骨石化,骨矿化增加,骨吸收减少[由RefSeq提供,2017年1月]This gene encodes a multi-domain protein tha
LRRK1基因突变与药物因子介绍
该基因编码一个富含亮氨酸的重复激酶和一个GDP/GTP结合蛋白的多结构域蛋白。编码的蛋白质被认为在调节骨量中起作用缺乏相似基因的小鼠表现出严重的骨石化,骨矿化增加,骨吸收减少[由RefSeq提供,2017年1月]This gene encodes a multi-domain protein tha
Determining-the-effects-of-nicotine-on-bone--in-chicks
ObjectiveThe purpose of this experiment is to determine how the development of bone and cartilage in a chick are affected by treating the embryo with
Function-of-SLRP-in-Bone:-An-Integrated-View
SLRPs (Small leucine-rich proteoglycans) are extracellular molecules that bind to TGF-betas, collagens and other matrix molecules. In vitro, SLRPs wer
Bone-Res-|-新发现!
南京大学曹望森/蒋青揭示跑步预防骨质疏松症的潜在机理 骨质疏松症(OP)是一种常见的骨骼疾病,涉及低骨矿物质密度(BMD),通常会导致脆性骨折,并且其发展受多种细胞病变的影响,与成骨基因的显性表观遗传改变有关。适当的体育锻炼有益于骨骼健康和骨质疏松症,据报道具有表观遗传调控能力。然而,运动对OP的
Isolation-of-osteoblasts-from-human-bone.
Bone samples were cleaned of adherent soft tissue and osteoblasts isolated by two methods.a. The bone was cut into small pieces (2 mm × 2 mm), washed
Shellless-cultures-of-chick-embryos
This experiment allows you to observe the development of a chick embryo outside its shell. Cultured chicks are also more accessible for manipulation.
Isolation-and-Culture-of-Multipotent-Stem-Cells-from-Human-Bone-Morrow
Bone marrow contains three types of stem cells:1. Hematopoietic stem cells give rise to the three classes of blood cells that are found in the circu
DIRECT-AND-SHORTTERM-PROCEDURE-FOR-HARVESTING-BONE-MARROW-CHROMOSOMES
I. PurposeTo identify chromosome anomalies in hematopoietic cells. Used especially for chromosome studies for hematological disorders such as preleuke
骨碱性磷酸酶(bone-alkaline-phosphatase)临床意义
正常参考范围:女:10~22U/L男:12~33U/L临床意义:1反映成骨细胞的活性或骨形成情况,成骨细胞活性和骨形成增加,骨碱性磷酸酶活性增加。2升高可见于patet`s病、原发性甲状旁腺机能亢进、骨软化和肾性营养不良等。
TNFRSF11A基因突变因子与药物介绍
这个基因编码的蛋白质是肿瘤坏死因子受体超家族的一员。该受体可与多种traf家族蛋白相互作用,诱导nf-kappa b和mapk8/jnk的活化。该受体及其配体是t细胞与树突状细胞相互作用的重要调节因子。该受体也是破骨细胞和淋巴结发育的重要介质。该位点的突变与家族性扩张性骨溶解、常染色体隐性骨岩症和骨
TNFRSF11A基因编码的功能和结构描述
这个基因编码的蛋白质是肿瘤坏死因子受体超家族的一员。该受体可与多种traf家族蛋白相互作用,诱导nf-kappa b和mapk8/jnk的活化。该受体及其配体是t细胞与树突状细胞相互作用的重要调节因子。该受体也是破骨细胞和淋巴结发育的重要介质。该位点的突变与家族性扩张性骨溶解、常染色体隐性骨岩症和骨
Bone-Research:靶向血管生成治疗炎症性疾病骨折不愈合
萎缩性骨折不愈合是一个重要的临床问题,治疗干预有限。在这项研究中,作者利用血清转移诱导的类风湿性关节炎(RA)建立了一种独特的临床相关性高的骨不连模型。关节炎小鼠骨折不愈合,骨折痂消失,血管生成减少,纤维化瘢痕组织形成导致生物力学性能失效,是临床萎缩性骨折不愈合的主要表现。机制上,作者证明了在R
SCI杂志IF分析:CR的影响因子最高,Bone-Res暂未公布
我们经过检索,发现了268个SCI杂志(如果不全,可以补充):经过iNature预测Cell Research是17.576,实际上是17.848(越来越高,呈直线上升);Bone Research预测是15.771(短短几年,影响因子变化非常大),但实际上这一次SCI影响因子的公布,没有Bon
Purification-of-Lin,-ckit+,-Sca1+-bone-marrow-cells-for-Culture
MATERIALSMedia:Heat inactivated FBS (56°C x 30 min)PBS + 2% heat-inactivated FBSIMDM + 20% heat-inactivated FBSViral transduction: Iscove's + 20%
Bone-Res:揭示经典Wnt信号途径介导YAP对骨稳态的调节
对成年人来说,骨始终处在流失和重建的稳态平衡状态,一个关键的调控基因应该既能够促进骨生成又能抑制脂肪细胞的生成。YAP是受Hippo信号途径负调控的一个转录因子,众多研究已经证明Hippo/YAP是一个在多器官发育和大小调节方面非常保守的信号途径。但YAP在骨稳态维持方面的确切功能还存在争议。最
Bone-Res:揭示经典Wnt信号途径介导YAP对骨稳态的调节
对成年人来说,骨始终处在流失和重建的稳态平衡状态,一个关键的调控基因应该既能够促进骨生成又能抑制脂肪细胞的生成。YAP是受Hippo信号途径负调控的一个转录因子,众多研究已经证明Hippo/YAP是一个在多器官发育和大小调节方面非常保守的信号途径。但YAP在骨稳态维持方面的确切功能还存在争议。最
Control-of-Gene-Expression-by-Vitamin-D-Receptor
The vitamin D receptor, VDR is the mediator of all genomic actions of vitamin D3 and its analogs. It belongs to a family of ligand induced transcripti
骨髓的结构和功能
骨髓(bone marrow)存在于骨松质腔隙和长骨骨髓腔内,由多种类型的细胞和网状结缔组织构成,根据其结构不同分为红骨髓(red bone mar-row)和黄骨髓(yellow bone marrow)。为柔软富有血液的组织。
人骨髓细胞和骨髓瘤的分析
骨髓(人体内的造血组织)骨髓(bone marrow)存在于骨松质腔隙和
Erythrocyte-Differentiation-Pathway
Stem cells in the bone marrow produce a variety of hematopoietic cell types from common progenitor cells under the influence of cytokines and growth f
血清PSA与ALP、BAP检测在前列腺癌骨转移诊断中的价值
作者:徐晓辉,徐颖,田华,王欢【摘要】 目的 探讨血清前列腺特异抗原(PSA)、碱性磷酸酶(ALP)、骨特异性碱性磷酸酶(BAP)测定在前列腺癌骨转移诊断中的价值。 方法 对50例前列腺癌(PCa)患者PSA、ALP、BAP测定结果进行回顾性分析。结果 35例PCa骨转移患者血清PSA、ALP、B
Ex-Vivo-Human-Primary-Mesenchymal-Stem-Cells-(MSCs)-Culture
Human bone marrow contains mesenchymal progenitors (mesenchymal stem cells, MSCs). MSCs produce adventitial cells in the human bone marrow microenvi
Small-Leucinerich-Proteoglycan-(SLRP)-molecules
The small leucine-rich proteoglycans (SLRPs) are a family of proteins that are present in extracellular matrix and that share in common multiple repea
GFP骨的冰冻切片实验方法
Protocol for Frozen section of GFP Bone:Fix the bone in 4% Paraformaldehyde at 4�C under constant agitation for 3 days.Decalcification in 14% EDTA sol
名词解释汇总:微量-X射线断层扫描相关监测指标(一)
CT值 CT值(CT number)是以水的CT值为零,而相对于其他物质X线的衰减值。例如,空气的CT值为 -1000,而骨密质的CT值为 +1000,人体除骨密质和肺以外,CT值基本在 -100~+100之间。CT值的标准单位是 HU(Hounsfield)。组织密
Dorsal-Root-Ganglion-Neuron-Culture-from-Adult-Rats
DescriptionProcedure for culturing and maintaining Dorsal Root Ganglion (DRG) neurons from adult rats. ProcedurePreparing Culture Surface- Collagen co