FunctionofSLRPinBone:AnIntegratedView
SLRPs (Small leucine-rich proteoglycans) are extracellular molecules that bind to TGF-betas, collagens and other matrix molecules. In vitro, SLRPs were shown to regulate collagen fibrillogenesis, a process essential in development, tissue repair, and metastasis. The resilience and strength of bone is due to the orderly mineralization of a specialized extracellular matrix (ECM) composed of type I collagen (90%) and a ......阅读全文
Function－of－SLRP－in－Bone:－An－Integrated－View
SLRPs (Small leucine-rich proteoglycans) are extracellular molecules that bind to TGF-betas, collagens and other matrix molecules. In vitro, SLRPs wer
Small－Leucinerich－Proteoglycan－(SLRP)－molecules
The small leucine-rich proteoglycans (SLRPs) are a family of proteins that are present in extracellular matrix and that share in common multiple repea
Bone－Remodelling
Bone density and structure is maintained through a balance of bone resorption by osteoclasts and bone deposition by osteoblasts. The combination of si
Regulation－And－Function－Of－ChREBP－in－Liver
Liver is the major site for carbohydrate metabolism (glycolysis and glycogen synthesis) and triglyceride synthesis (lipogenesis). While insulin was lo
Regulators－of－Bone－Mineralization
Osteoblasts mineralize bone matrix by promoting hydroxyapatite crystal formation and growth in the interior of membrane-limited matrix vesicles (MVs)
Isolation－of－bone－marrow
(contributed by Chris Jackson (chris.jackson@bris.ac.uk))A protocol I have used to isolate rat bone marrow is: 1. Kill the rat and dissect out the fem
Mitochondria－Structure－and－Function－－Theoretical－Details
Mitochondria Structure and Function - Theoretical DetailsIn an attempt to be concise and understandable, introductory level courses and textbooks freq
Reverse－Transfection－for－Gene－Function－Analysis
This guide describes a microarray-based system for the functional analysis in mammalian cells of many genes in parallel. Mammalian cells are cultured
Open－Integrated－Factory－中的称重模块
汉诺威工业博览会上展出了一件展品，该产品采用一个通过具有统一架构的开放平台通信技术提交数据的称重模块，为制造执行系统与质量控制设备之间的无缝通信提供了可能。通过以下网址了解关于 WMS 称重模块的更多信息 2017 年汉诺威工业博览会上展出了 SAP 研发的 Open Integrated Fac
whats－the－function－of－compressed－air－filter
Compressed air is an essential utility in many industrial applications, including pneumatic tools, packaging, and conveying systems. It is a clean, ef
Transcriptome－Coexpression－Analysis－Using－ATTEDII－for－Integrated－...
Transcriptome coexpression analysis is an excellent tool for predicting the physiological functions of genes. It is based on the “guilt-by-associa
Bone－Res－|－新发现！
南京大学曹望森/蒋青揭示跑步预防骨质疏松症的潜在机理 骨质疏松症（OP）是一种常见的骨骼疾病，涉及低骨矿物质密度（BMD），通常会导致脆性骨折，并且其发展受多种细胞病变的影响，与成骨基因的显性表观遗传改变有关。适当的体育锻炼有益于骨骼健康和骨质疏松症，据报道具有表观遗传调控能力。然而，运动对OP的
Determining－the－effects－of－nicotine－on－bone－－in－chicks
ObjectiveThe purpose of this experiment is to determine how the development of bone and cartilage in a chick are affected by treating the embryo with
Isolation－of－osteoblasts－from－human－bone.
Bone samples were cleaned of adherent soft tissue and osteoblasts isolated by two methods.a. The bone was cut into small pieces (2 mm × 2 mm), washed
Angiotensinconverting－enzyme－2－regulates－heart－function
Cardiovascular diseases are predicted to be the most common cause of death worldwide by 2020. The major regulator of blood pressure homeostasis is the
Isolation－and－Culture－of－Multipotent－Stem－Cells－from－Human－Bone－Morrow
Bone marrow contains three types of stem cells:1. Hematopoietic stem cells give rise to the three classes of blood cells that are found in the circu
DIRECT－AND－SHORTTERM－PROCEDURE－FOR－HARVESTING－BONE－MARROW－CHROMOSOMES
I. PurposeTo identify chromosome anomalies in hematopoietic cells. Used especially for chromosome studies for hematological disorders such as preleuke
VIEW：新兴光流控技术在生物诊断方面的应用
光流控是一门综合了微流控和光学优势的新兴交叉学科，它将高精度的流体操控和高灵敏的光学检测有机结合在一起，能提供强大的生化检测功能，近年来将光流控技术应用于生物诊断方向的研究发展非常迅速，特别是在疾病的早期诊断方面，生物标志物的超低含量以及定期常规的检测需求急需一种既有高灵敏度又便捷低成本的检测方
Functional－Genomics－and－Structural－Biology－in－the－Definition－of－Gene...
By mid-2007, the three-dimensional (3D) structures of some 45,000 proteins have been solved, over a period where the linear structures of millions
骨碱性磷酸酶（bone－alkaline－phosphatase）临床意义
正常参考范围：女:10~22U/L男:12~33U/L临床意义：1反映成骨细胞的活性或骨形成情况，成骨细胞活性和骨形成增加，骨碱性磷酸酶活性增加。2升高可见于patet`s病、原发性甲状旁腺机能亢进、骨软化和肾性营养不良等。
SCI杂志IF分析：CR的影响因子最高，Bone－Res暂未公布
我们经过检索，发现了268个SCI杂志（如果不全，可以补充）：经过iNature预测Cell Research是17.576，实际上是17.848（越来越高，呈直线上升）；Bone Research预测是15.771（短短几年，影响因子变化非常大），但实际上这一次SCI影响因子的公布，没有Bon
Bone－Research：靶向血管生成治疗炎症性疾病骨折不愈合
萎缩性骨折不愈合是一个重要的临床问题，治疗干预有限。在这项研究中，作者利用血清转移诱导的类风湿性关节炎(RA)建立了一种独特的临床相关性高的骨不连模型。关节炎小鼠骨折不愈合，骨折痂消失，血管生成减少，纤维化瘢痕组织形成导致生物力学性能失效，是临床萎缩性骨折不愈合的主要表现。机制上，作者证明了在R
Purification－of－Lin,－ckit+,－Sca1+－bone－marrow－cells－for－Culture
MATERIALSMedia:Heat inactivated FBS (56°C x 30 min)PBS + 2% heat-inactivated FBSIMDM + 20% heat-inactivated FBSViral transduction: Iscove's + 20%
Ghrelin:－Regulation－of－Food－Intake－and－Energy－Homeostasis
The somatotropic axis. The synthesis and release of growth hormone (GH) from the pituitary are controlled by the hypothalamic hormones GH-releasing ho
A－Collection－of－PlantSpecific－Genomic－Data－and－Resources－at－NCBI
The National Center for Biotechnology Information (NCBI) provides a data-rich environment in support of genomic research by collecting the biologi
名词解释汇总：微量－X射线断层扫描相关监测指标（一）
CT值 CT值（CT number）是以水的CT值为零，而相对于其他物质X线的衰减值。例如，空气的CT值为 -1000，而骨密质的CT值为 +1000，人体除骨密质和肺以外，CT值基本在 -100～+100之间。CT值的标准单位是 HU（Hounsfield）。组织密
Bone－Res：揭示经典Wnt信号途径介导YAP对骨稳态的调节
对成年人来说，骨始终处在流失和重建的稳态平衡状态，一个关键的调控基因应该既能够促进骨生成又能抑制脂肪细胞的生成。YAP是受Hippo信号途径负调控的一个转录因子，众多研究已经证明Hippo/YAP是一个在多器官发育和大小调节方面非常保守的信号途径。但YAP在骨稳态维持方面的确切功能还存在争议。最
Bone－Res：揭示经典Wnt信号途径介导YAP对骨稳态的调节
对成年人来说，骨始终处在流失和重建的稳态平衡状态，一个关键的调控基因应该既能够促进骨生成又能抑制脂肪细胞的生成。YAP是受Hippo信号途径负调控的一个转录因子，众多研究已经证明Hippo/YAP是一个在多器官发育和大小调节方面非常保守的信号途径。但YAP在骨稳态维持方面的确切功能还存在争议。最
解决非特异吸附的新方法
免疫分析中，非特异的蛋白吸附常常是阻碍高灵敏度的一个重要的因素。来自中科院等单位的研究小组开发了一种新的固相载体，有望达到"0"非特异吸附。以下是他们在 Analytical Chemistry 的文章摘要。Integrated Poly(dimethysiloxane) with an Intri
14日直播｜清华大学教授讲述柔性电子技术
原文地址：http://news.sciencenet.cn/htmlnews/2023/4/498426.shtm 直播时间：2023年4月14日（周五）20:00-21:30 直播平台： 科学网APP （科学网微博直播间链接） 科学网微博 科学网视