ActivationofCskbycAMPdependentProteinKinaseInhibitsSignaling
Interaction of T cell receptor with specific antigen in the context of MHC II activates a signal transduction pathway that leads to T cell activation. In the T cell receptor signaling pathway, the src family kinases Lck and Fyn are activated to phosphorylate proteins in the T cell receptor complex which recruit and activate the ZAP70 kinase. The activation of ZAP70 phosphorylates downstream targets that activate MAP ......阅读全文
Activation－of－Csk－by－cAMPdependent－Protein－Kinase－Inhibits－Signaling
Interaction of T cell receptor with specific antigen in the context of MHC II activates a signal transduction pathway that leads to T cell activation.
Activation－of－cAMPdependent－protein－kinase,－PKA
G-protein coupled receptors (GPCRs) are one of the largest gene families of signaling proteins. Residing in the plasma membrane with seven transmembra
Ca++/－Calmodulindependent－Protein－Kinase－Activation
The calcium/calmodulin-dependent kinases (CaMKs) are involved in a large number of cellular responses induced by hormones, neurotransmitters and other
Protein－Kinase－A－at－the－Centrosome
Protein kinase A regulatory subunit RIIalpha (PKA-RIIa) is tightly bound to centrosomal structures during interphase through interaction with the A-ki
Sprouty－regulation－of－tyrosine－kinase－signals
Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors,
Angiotensin－Protein－Kinase－Assay
James Hardwick's angiotensin assay protocolThis specific procedure was developed to assay the activity of the Lck kinase expressed from a retrovir
Signaling－of－Hepatocyte－Growth－Factor－Receptor
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutate
RhoSelective－Guanine－Exchange－FactorAKAP13－Mediates－Stress－Fiber－Formation
The A-kinase anchor protein 13 (AKAP13, also known as AKAP-LBC) is one of a group of structurally diverse proteins, which have the common function of
Human－Cytomegalovirus－and－Map－Kinase－Pathways
To replicate in the host cell, viruses commandeer cellular signaling pathways. Cytomegalovirus (CMV) is a DNA virus with that is widespread in the pop
Regulation－of－ck1/cdk5－by－type－1－glutamate－receptors
Cdk5 is a cyclin dependent protein kinase involved in dopaminergic signaling in the neostriatal region of the brain. The role of cdk5 in dopamine resp
TSP1－Induced－Apoptosis－in－Microvascular－Endothelial－Cell
As tissues grow they require angiogenesis to occur if they are to be supplied with blood vessels and survive. Factors that inhibit angiogenesis might
PTEN－dependent－cell－cycle－arrest－and－apoptosis
PTEN is a tumor suppressor gene. Recombinant PTEN is capable of dephosphorylating phosphatidylinositol 3,4,5-triphosphate[PI(3,4,5)P3], the product of
Multistep－Regulation－of－Transcription－by－Pitx2
Many transcription factors play essential roles in normal development by determining the proliferation and differentiation of cells. The coordinated t
Aspirin－Blocks－Signaling－Pathway－Involved－in－Platelet－Activation
Activation of the protease-activated GPCRs in platelets contributes to platelet activation in clotting. The protease-activated receptors PAR1 and PAR4
Inhibition－of－Cellular－Proliferation－by－Gleevec
The drug Gleevec (also known as imatinib mesylate or STI-571) was approved by the FDA in 2001 for the treatment of CML, chronic myeloid leukemia. Whil
Ras－Signaling－Pathway
Ras activates many signaling cascades. Here we illustrate some of the well-characterized cascades in a generic compilation of effector molecules. The
PAG1基因编码功能及结构描述
该基因编码的蛋白是一种与酪氨酸激酶csk蛋白结合的iii型跨膜衔接蛋白。它被认为参与调节T细胞的活化。The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyro
Keratinocyte－Differentiation
The epidermis, which provides a protective barrier that undergoes a constant renewal, is a multi-layered tissue with the proliferating cells located i
PAG1基因突变与药物因子介绍
该基因编码的蛋白是一种与酪氨酸激酶csk蛋白结合的iii型跨膜衔接蛋白。它被认为参与调节T细胞的活化[由RefSeq提供，2008年7月]The protein encoded by this gene is a type III transmembrane adaptor protein that
IL10－Antiinflammatory－Signaling－Pathway
IL-10 is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by
Rac－1－cell－motility－signaling－pathway
Rac-1 is a small G-protein in the Rho family that regulates cell motility in response to extracellular signals. Several changes in cytoskeletal struct
Actions－of－Nitric－Oxide－in－the－Heart
Nitric oxide (NO) has a number of important physiological actions in the cardiovascular system. In the heart, NO plays role in keeping the vessels pat
mTOR－Signaling－Pathway
mTOR (mammalian target of rapamycin) appears to play a central role in signaling caused by nutrients and mitogens such as growth factors to regulate t
Bioactive－Peptide－Induced－Signaling－Pathway
Many different peptides act as signaling molecules, including the proinflammatory peptide bradykinin, the protease enzyme thrombin, and the blood pres
Activation－of－Src－by－Proteintyrosine－phosphatase－alpha
Progression through the cell cycle is accompanied by activation of the proto-oncogene c-Src, a protein tyrosine kinase. Overexpression of Src leads to
Activation－of－PKC－through－G－protein－coupled－receptor
G-protein coupled receptors (GPCRs) transduce a variety of signals from the extracellular environment across the plasma membrane. One of the common si
Links－between－Pyk2－and－Map－Kinases
This diagram is a compilation of Pyk2 effort cascades. In specific cell types the receptor and effoectors will vary. Binding of a transmembrane recept
GPS2基因突变与药物因子介绍
该基因编码一种参与g蛋白丝裂原活化蛋白激酶（mapk）信号级联的蛋白。当该基因在哺乳动物细胞中过度表达时，可能会抑制ras和mapk介导的信号并干扰jnk活性，提示该基因的功能可能是信号抑制。编码蛋白是ncor1-hdac3（核受体辅加压素1-组蛋白脱乙酰基酶3）复合物的一个完整亚单位，研究表明，该
GPS2基因编码功能及结构描述
该基因编码一种参与g蛋白丝裂原活化蛋白激酶（mapk）信号级联的蛋白。当该基因在哺乳动物细胞中过度表达时，可能会抑制ras和mapk介导的信号并干扰jnk活性，提示该基因的功能可能是信号抑制。编码蛋白是ncor1-hdac3（核受体辅加压素1-组蛋白脱乙酰基酶3）复合物的一个完整亚单位，研究表明，该
GPS2基因编码功能及结构描述
该基因编码一种参与g蛋白丝裂原活化蛋白激酶（mapk）信号级联的蛋白。当该基因在哺乳动物细胞中过度表达时，可能会抑制ras和mapk介导的信号并干扰jnk活性，提示该基因的功能可能是信号抑制。编码蛋白是ncor1-hdac3（核受体辅加压素1-组蛋白脱乙酰基酶3）复合物的一个完整亚单位，研究表明，该