HumanCytomegalovirusandMapKinasePathways
To replicate in the host cell, viruses commandeer cellular signaling pathways. Cytomegalovirus (CMV) is a DNA virus with that is widespread in the population but usually causes disease only in immunocompromised individuals and is also a viral cause of birth defects. One of the actions of CMV in the host cell is to stimulate MAP kinase pathways. Both p38 and ERK kinases are activated by CMV infection through activatio......阅读全文
Human－Cytomegalovirus－and－Map－Kinase－Pathways
To replicate in the host cell, viruses commandeer cellular signaling pathways. Cytomegalovirus (CMV) is a DNA virus with that is widespread in the pop
Regulation－of－MAP－Kinase－Pathways－Through－Dual－Specificity－Phosphatases
Mitogen-activated protein (MAP) kinases are important players in signal transduction pathways activated by a range of stimuli and mediate a number of
Map－Kinase－Inactivation－of－SMRT－Corepressor
Corepressors are coregulators that interact with transcriptional silencers in a variety of pathways such as cell proliferation, differentiation and ap
NFkB－activation－by－Nontypeable－Hemophilus－influenzae
The role of Hemophilus influenzae in ear infections and chronic obstructive pulmonary disease includes the induction of an inflammatory response throu
fMLP－induced－chemokine－gene－expression－in－HMC1－cells
Neutrophils respond to bacterial infection by releasing reactive oxygen species that kill bacteria and by expressing chemokines that attract other imm
CCR3－signaling－in－Eosinophils
Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic reactions in skin and airway. The eosinophil response
Phosphorylation－of－MEK1－by－cdk5/p35－down－regulates－the－MAP－kinase－pathway
Map kinases transduce responses to extracellular signals by a variety of routes, and communicate with other pathways through extensive crosstalk netwo
Keratinocyte－Differentiation
The epidermis, which provides a protective barrier that undergoes a constant renewal, is a multi-layered tissue with the proliferating cells located i
TNF/Stress－Related－Signaling
TNF acts on several different signaling pathways through two cell surface receptors, TNFR1 and TNFR2 (See TNFR1 and TNFR2 Signaling Pathways) to regul
Bioactive－Peptide－Induced－Signaling－Pathway
Many different peptides act as signaling molecules, including the proinflammatory peptide bradykinin, the protease enzyme thrombin, and the blood pres
RasIndependent－pathway－in－NK－cellmediated－cytotoxicity
NK (natural killer) cells are lymphocytes distinct from B and T cells that induce perforin-mediated lysis of tumor cells and virus-infected cells. NK
Nerve－growth－factor－pathway－(NGF)
Nerve growth factor (NGF) is one of a family of neurotrophins that induce the survival and proliferation of neurons. In cell culture NGF induces the f
Stress－Induction－of－HSP－Regulation
Mammalian cells can respond to a variety of stresses such as heat, cold, oxidative stress, metabolic disturbance, and environmental toxins through nec
Multiple－antiapoptotic－pathways－from－IGF1R－signaling－lead－to－BAD－phosphory
IGF-1R, the type 1 receptor for insulin-like growth factor, mediates cell survival and growth in response to its ligands IGF-1 and IGF-2. This tyrosin
Stat3－Signaling－Pathway
STATs, Signal Transducers and Activators of Transcription, are transcription factors that are phosphorylated by JAK kinases in response to cytokine ac
EGF－Signaling－Pathway
The epidermal growth factor (EGF) peptide induces cellular proliferation through the EGF receptor, which has a tyrosine kinase cytoplasmic domain, a s
Feeder－Pathways－for－Glycolysis
The glycolytic pathway begins with the simple sugar glucose and leads to pyruvate and eventually the Kreb's cycle. Dietary carbohydrates include a
Trka－Receptor－Signaling－Pathway
Nerve growth factor (NGF) is a neurotrophic factor that stimulates neuronal survival and growth through TrkA, a member of the trk family of tyrosine k
Thrombin－signaling－and－proteaseactivated－receptors
Thrombin is an extracellular protease that is involved in the clotting of blood and inflammation through its action on platelets and endothelial cells
MAPKinase－Signaling－Pathway
The ever evolving mitogen-activated protein kinase (MAP kinase) pathways consist of four major groupings and numerous related proteins which constitut
EPOR基因编码功能及结构描述
该基因编码红细胞生成素受体，红细胞生成素受体是细胞因子受体家族的一员。在促红细胞生成素结合后，该受体激活JAK2酪氨酸激酶，激活不同的细胞内途径，包括：ras/map激酶、磷脂酰肌醇3激酶和stat转录因子。受刺激的促红细胞生成素受体似乎在红细胞存活中起作用。红细胞生成素受体缺陷可导致红白血病和家族
与白血病相关的EPOR基因编码功能描述
该基因编码红细胞生成素受体，红细胞生成素受体是细胞因子受体家族的一员。在促红细胞生成素结合后，该受体激活JAK2酪氨酸激酶，激活不同的细胞内途径，包括：ras/map激酶、磷脂酰肌醇3激酶和stat转录因子。受刺激的促红细胞生成素受体似乎在红细胞存活中起作用。红细胞生成素受体缺陷可导致红白血病和家族
EPOR基因突变与药物因子介绍
该基因编码红细胞生成素受体，红细胞生成素受体是细胞因子受体家族的一员。在促红细胞生成素结合后，该受体激活JAK2酪氨酸激酶，激活不同的细胞内途径，包括：ras/map激酶、磷脂酰肌醇3激酶和stat转录因子。受刺激的促红细胞生成素受体似乎在红细胞存活中起作用。红细胞生成素受体缺陷可导致红白血病和家族
The－41BBdependent－immune－response
The activation of T cells requires a co-stimulatory signal with T cell receptor activation, provided in many cases by activation of CD28 in resting T
Signaling－Pathway－from－GProtein－Families
G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP. In contrast Gai-coupled receptors inhibit AC and so reduce cA
Role－of－PI3K－subunit－p85－in－regulation－of－Actin－Organization
Migration of cells is involved in essential functions such as development, invasiveness of cancer cells, leukocyte movement toward chemotactic signals
Lck－and－Fyn－tyrosine－kinases－in－initiation－of－TCR－Activation
T cell activation is initiated by recognition of antigen by the T cell receptor (TCR) in the context of Class II MHC on an antigen-presenting cell. Th
Anthrax－Toxin－Mechanism－of－Action
One of the key causes of anthrax virulence is the production of three specific factors by the gram-positive spore forming bacteria Bacillus anthracis.
PTEN－dependent－cell－cycle－arrest－and－apoptosis
PTEN is a tumor suppressor gene. Recombinant PTEN is capable of dephosphorylating phosphatidylinositol 3,4,5-triphosphate[PI(3,4,5)P3], the product of
p38－MAPK－Signaling－Pathway
p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are deli