AKAP95roleinmitosisandchromosomedynamics
The chromatin packaging of the genome is dynamic, changing with the cell cycle and with transcriptional regulation. During mitosis, chromatin is condensed for segregation of chromosomes, while for transcription chromatin is more open. The nuclear matrix, or scaffold, is a protein network in the nucleus providing structure and regulating chromatin condensation. Regulated interactions of matrix proteins with each other......阅读全文
AKAP95-role-in-mitosis-and-chromosome-dynamics
The chromatin packaging of the genome is dynamic, changing with the cell cycle and with transcriptional regulation. During mitosis, chromatin is conde
Protein-Kinase-A-at-the-Centrosome
Protein kinase A regulatory subunit RIIalpha (PKA-RIIa) is tightly bound to centrosomal structures during interphase through interaction with the A-ki
Metaphase-chromosome-preparation
Materials: RPMI 1640 medium fetal calf serum (FCS), 20% Colcemid (e.g. Boehringer Mannheim cell biology reagents, Best.-Nr. 295892) cell cuture flask
与肺癌相关的AURKA基因编码功能描述
该基因编码的蛋白是一种细胞周期调节激酶,在染色体分离过程中似乎与纺锤体极的微管形成和/或稳定有关。编码蛋白存在于有丝分裂的间期细胞的中心体和纺锤体两极。该基因可能在肿瘤的发展和进展中起作用。在1号染色体上发现一个经过加工的假基因,在10号染色体上发现一个未经加工的假基因。已发现该基因的多个编码相同蛋
与肺癌相关的AURKA基因编码功能描述
该基因编码的蛋白是一种细胞周期调节激酶,在染色体分离过程中似乎与纺锤体极的微管形成和/或稳定有关。编码蛋白存在于有丝分裂的间期细胞的中心体和纺锤体两极。该基因可能在肿瘤的发展和进展中起作用。在1号染色体上发现一个经过加工的假基因,在10号染色体上发现一个未经加工的假基因。已发现该基因的多个编码相同蛋
AURKA与癌症相关的基因编码功能描述
该基因编码的蛋白是一种细胞周期调节激酶,在染色体分离过程中似乎与纺锤体极的微管形成和/或稳定有关。编码蛋白存在于有丝分裂的间期细胞的中心体和纺锤体两极。该基因可能在肿瘤的发展和进展中起作用。在1号染色体上发现一个经过加工的假基因,在10号染色体上发现一个未经加工的假基因。已发现该基因的多个编码相同蛋
与细胞周期信号通路相关因子介绍AURKA
该基因编码的蛋白是一种细胞周期调节激酶,在染色体分离过程中似乎与纺锤体极的微管形成和/或稳定有关。编码蛋白存在于有丝分裂的间期细胞的中心体和纺锤体两极。该基因可能在肿瘤的发展和进展中起作用。在1号染色体上发现一个经过加工的假基因,在10号染色体上发现一个未经加工的假基因。已发现该基因的多个编码相同蛋
细胞周期信号通路相关AURKA
该基因编码的蛋白是一种细胞周期调节激酶,在染色体分离过程中似乎与纺锤体极的微管形成和/或稳定有关。编码蛋白存在于有丝分裂的间期细胞的中心体和纺锤体两极。该基因可能在肿瘤的发展和进展中起作用。在1号染色体上发现一个经过加工的假基因,在10号染色体上发现一个未经加工的假基因。已发现该基因的多个编码相同蛋
与食管癌相关的VEGFA基因编码功能描述
该基因编码的蛋白是一种细胞周期调节激酶,在染色体分离过程中似乎与纺锤体极的微管形成和/或稳定有关。编码蛋白存在于有丝分裂的间期细胞的中心体和纺锤体两极。该基因可能在肿瘤的发展和进展中起作用。在1号染色体上发现一个经过加工的假基因,在10号染色体上发现一个未经加工的假基因。已发现该基因的多个编码相同蛋
AURKA基因突变与药物因子介绍
该基因编码的蛋白是一种细胞周期调节激酶,在染色体分离过程中似乎与纺锤体极的微管形成和/或稳定有关。编码蛋白存在于有丝分裂的间期细胞的中心体和纺锤体两极。该基因可能在肿瘤的发展和进展中起作用。在1号染色体上发现一个经过加工的假基因,在10号染色体上发现一个未经加工的假基因。已发现该基因的多个编码相同蛋
与乳腺癌相关的AURKA基因编码功能描述
该基因编码的蛋白是一种细胞周期调节激酶,在染色体分离过程中似乎与纺锤体极的微管形成和/或稳定有关。编码蛋白存在于有丝分裂的间期细胞的中心体和纺锤体两极。该基因可能在肿瘤的发展和进展中起作用。在1号染色体上发现一个经过加工的假基因,在10号染色体上发现一个未经加工的假基因。已发现该基因的多个编码相同蛋
AURKA基因编码功能及结构描述
该基因编码的蛋白是一种细胞周期调节激酶,在染色体分离过程中似乎与纺锤体极的微管形成和/或稳定有关。编码蛋白存在于有丝分裂的间期细胞的中心体和纺锤体两极。该基因可能在肿瘤的发展和进展中起作用。在1号染色体上发现一个经过加工的假基因,在10号染色体上发现一个未经加工的假基因。已发现该基因的多个编码相同蛋
AKAP8基因编码功能及结构描述
这个基因编码a激酶锚蛋白家族的一个成员。a激酶锚定蛋白是含有蛋白激酶a(pka)的ri/rii亚单位的结合域并将pka和其他信号分子募集到特定亚细胞位置的支架蛋白。该基因编码一个核a激酶锚定蛋白,该蛋白与pka的riiα亚单位结合,并可能通过将pka和condensin复合物靶向染色质在有丝分裂过程
AKAP8基因突变与药物因子介绍
这个基因编码a激酶锚蛋白家族的一个成员。a激酶锚定蛋白是含有蛋白激酶a(pka)的ri/rii亚单位的结合域并将pka和其他信号分子募集到特定亚细胞位置的支架蛋白。该基因编码一个核a激酶锚定蛋白,该蛋白与pka的riiα亚单位结合,并可能通过将pka和condensin复合物靶向染色质在有丝分裂过程
TISSUE-FIBROBLAST-CULTURES-FOR-CHROMOSOME-ANALYSIS
I. Purpose:A: Skin tissue may be used for chromosome analysis in special cases when the results from peripheral blood are inconclusive, e.g. suspected
TISSUE-FIBROBLAST-CULTURES-FOR-CHROMOSOME-ANALYSIS
实验概要 Skin tissue may be used for chromosome analysis in special cases when the results from peripheral blood are inconclusive, e.g. suspect
SOLID-TUMOR-CULTURES-FOR-CHROMOSOME-ANALYSIS
I. Purpose:A. Samples of solid tumors or lymph nodes may be sent from patients with cancer. These samples should be processed directly and also set up
Role-of-Ran-in-mitotic-spindle-regulation
One of the central features of mitotic cell division is the formation of the spindle that segregates chromosomes into each daughter cell. Chromosomes
Exercise-12.9--Eukaryote-Growth-Dynamics
Exercise 12.9 - Eukaryote Growth DynamicsLEVEL IIMaterialsSuspension cultures set up from Exercise 12.8Sterile transfer pipettesMaterials for viabilit
Role-of-Mitochondria-in-Apoptotic-Signaling
Mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein
Preparation-Of-Peripheral-Blood-Cells-For-Chromosome-Analysis
实验概要Lymphocytes are differentiated cells which normally do not undergo subsequent cell divisions. By culturing lymphocytes in the presence of a mito
Culture-of-Peripheral-Blood-Lymphocytes-for-Chromosome-Analysis
实验概要Provide information about chromosomal abnormalities.实验原理The blood cell karyotyping method was developed to provide information about chromosomal
Cell-Cycles--Introduction
The onion root tip and the whitefish blastula remain as the standard introduction to the study of mitosis. The onion has easily observable chromosomes
The-Role-of-Eosinophils-in-the-Chemokine-Network-of-Allergy
The inflammatory response associated with asthma is characterized by the recruitment of eosinophils from the bronchial microcirculation in response to
Endocytotic-role-of-NDK,-Phosphins-and-Dynamin
Reliable neurotransmitter release requires the presence of sufficent numbers of synaptic vesicles. The process of synaptic vesicle endocytosis (SVE) i
Flow-Cell-Assays-with-Microtubules:-Motility/Dynamics-in-Fluorescence
Flow cell assays are very useful for studying microtubule motility, microtubule dynamics, kinetochore-microtubule interactions and action of severing/
Role-of-nicotinic-acetylcholine-receptors-in-the-regulation-of-apoptosis
Nicotinic acetylcholine receptors are essential for neuromuscular signaling and are also expressed in non-neuronal tissues, where their function is le
Role-of-Tob-in-Tcell-activation
Regulation of T cell activation is a crucial component of balanced functioning of the immune system. If the T cell response is too great and activatio
Role-of-Parkin-in-the-UbiquitinProteasomal-Pathway
The motor defects of Parkinson's disease are related to the loss of dopaminergic neurons in specific brain regions. Examination of these neurons i
Role-of-Erk5-in-Neuronal-Survival
Axons extend significant distances to innervate target tissues. At the site of innervation, target tissues release neurotrophins including NGF, BDNF a