WIKI资讯
WIKI资讯
Phosphorylation of SubstratesScott T. Eblen, N. Vinay Kumar, and Michael J. WeberDepartment of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, VA 22908Excerpted from Protein: Protein Interactions, Second EditionEdited by Erica A. Golemis and Peter D. AdamsABSTRACTIdeally, one would like to be able to directly phosphorylate substrates in an intact cell. This could potentiall......阅读全文
实验概要Ideally, one would like to be able to directly phosphorylate substrates in an intact cell. This could potentially be performed by intr
实验概要 Small synthetic peptide substrates are especially well suited for applications such as assays of tyrosine kinases
Progression through the cell cycle is accompanied by activation of the proto-oncogene c-Src, a protein tyrosine kinase. Overexpression of Src leads to
Protein kinase A regulatory subunit RIIalpha (PKA-RIIa) is tightly bound to centrosomal structures during interphase through interaction with the A-ki
Identification of a Mutant Kinase/ATP Analog PairScott T. Eblen, N. Vinay Kumar, and Michael J. WeberDepartment of Microbiology and Cancer Center, Uni
Screening Kinase Phosphorylation Motifs Using Peptide LibrariesIsaac A. Manke and Michael B. YaffeCenter for Cancer Research, Massachusetts Institute
The drug Gleevec (also known as imatinib mesylate or STI-571) was approved by the FDA in 2001 for the treatment of CML, chronic myeloid leukemia. Whil
长时间的清醒会导致认知障碍，而睡眠能够通过分子生物化学的改变来“刷新”大脑，这些变化影响着神经元的可塑性和大脑的功能。然而，多年来，“想睡觉”背后的分子基础一直没有被很好地理解。 目前关于睡眠-觉醒周期（sleep-wake cycle）的理论表明，觉醒编码记忆，而睡眠则巩固记忆并修复突触内稳
The binding of ?-arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kinase activation complex using ?-arrestin as a scaffold, with sub
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutate
Tyrosine Kinase Assay Using Synthetic Peptides (T. Miller)Small synthetic peptide substrates are especially well suited for applications such as