RegulationofBADphosphorylation
The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112,136 and 155). Phosphorylation at these sites results in loss of the ability of BAD to heterodimerize with the survival proteins BCL-XL or BCL-2. Phosphorylated BAD binds to 14-3-3 and is sequestered in the cytoplasm. While ser-136 phosphorylation is concordant with the activation of Akt, Ser-112 phosphorylation requ......阅读全文
Regulation－of－BAD－phosphorylation
The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112,136 and 155). Phosphorylation at these sites re
Regulation－of－p27－Phosphorylation－during－Cell－Cycle－Progression
p27/Kip1 regulates the cell cycle by inhibiting the checkpoint kinase cdk2/cyclin E and blocking cell cycle progression through the G1-S transition. C
Dephosphorylation－...
实验概要The method provides a protocol for removal of phosphate groups from proteins, before or after blotting. To demonstrate the specificity of an ant
Dephosphorylation－of－DNA
De-phosphorylation of DNAThe preferred method of de-phosphorylation uses the buffer system described by Pharmacia for most of their restriction endonu
Regulation－of－Spermatogenesis－by－CREM
The transcriptional regulator CREM plays a key role in spermatogenesis, acting as a central transcription factor triggering a cascade of transcription
Regulation－of－hematopoiesis－by－cytokines
The process of hematopoesis is regulated by various cytokines. The combination of cytokines stimulates the proliferation and/or differentiation of the
AKT－Signaling－Pathway
Many cell-surface receptors induce production of second messengers like PIP3, phosphatidylinositol 3,4,5-trisphosphate, that convey signals to the cyt
Regulation－And－Function－Of－ChREBP－in－Liver
Liver is the major site for carbohydrate metabolism (glycolysis and glycogen synthesis) and triglyceride synthesis (lipogenesis). While insulin was lo
Cyclins－and－Cell－Cycle－Regulation
The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted f
CDK－Regulation－of－DNA－Replication
Initiation of DNA replication in eukaryotes is a highly conserved, multi-step process (replication licensing) designed to restrict initiation events t
ChREBP－regulation－by－carbohydrates－and－cAMP
Although insulin and glucagon play important roles in regulating the response of cells to nutrients, cells also respond to carbohydrates through trans
Stress－Induction－of－HSP－Regulation
Mammalian cells can respond to a variety of stresses such as heat, cold, oxidative stress, metabolic disturbance, and environmental toxins through nec
Regulation－of－PGC1a
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nucl
Regulation－of－eIF2
Protein phosphorylation plays an important role in the control of translation by eukaryotic initiation factor-2 (eIF-2). eIF-2 binds GTP and Met-tRNAi
Regulation－of－transcriptional－activity－by－PML
The PML nuclear bodies are ring-shaped nuclear substructures associated with the regulation of transcription, transformation, cell growth, and apoptos
BAD基因编码功能及结构描述
这个基因编码的蛋白质是bcl-2家族的一员。bcl-2家族成员是细胞程序性死亡的调节者。该蛋白通过与bcl-xl和bcl-2形成异二聚体，并逆转其死亡抑制活性，从而对细胞凋亡起到积极的调节作用。这种蛋白的促凋亡活性是通过磷酸化调节的。蛋白激酶akt和map激酶以及蛋白磷酸酶钙调磷酸酶参与了该蛋白的调
BAD基因编码功能及结构描述
这个基因编码的蛋白质是bcl-2家族的一员。bcl-2家族成员是细胞程序性死亡的调节者。该蛋白通过与bcl-xl和bcl-2形成异二聚体，并逆转其死亡抑制活性，从而对细胞凋亡起到积极的调节作用。这种蛋白的促凋亡活性是通过磷酸化调节的。蛋白激酶akt和map激酶以及蛋白磷酸酶钙调磷酸酶参与了该蛋白的调
PKCcatalyzed－phosphorylation－of－inhibitory－phosphoprotein－of－phosphatase
The phosphorylation of myosin affects its role in smooth muscle contraction, platelet formation and possibly other processes. Phosphorylation by myosi
Role－of－Ran－in－mitotic－spindle－regulation
One of the central features of mitotic cell division is the formation of the spindle that segregates chromosomes into each daughter cell. Chromosomes
FXR－and－LXR－Regulation－of－Cholesterol－Metabolism
Cholesterol is essential for life and a key in the development of heart disease. Cholesterol homeostasis is achieved through regulation of cholesterol
Sprouty－regulation－of－tyrosine－kinase－signals
Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors,
BAD基因的结构特点和生理作用
这个基因编码的蛋白质是bcl-2家族的一员。bcl-2家族成员是细胞程序性死亡的调节者。该蛋白通过与bcl-xl和bcl-2形成异二聚体，并逆转其死亡抑制活性，从而对细胞凋亡起到积极的调节作用。这种蛋白的促凋亡活性是通过磷酸化调节的。蛋白激酶akt和map激酶以及蛋白磷酸酶钙调磷酸酶参与了该蛋白的调
BAD基因突变与药物因子介绍
这个基因编码的蛋白质是bcl-2家族的一员。bcl-2家族成员是细胞程序性死亡的调节者。该蛋白通过与bcl-xl和bcl-2形成异二聚体，并逆转其死亡抑制活性，从而对细胞凋亡起到积极的调节作用。这种蛋白的促凋亡活性是通过磷酸化调节的。蛋白激酶akt和map激酶以及蛋白磷酸酶钙调磷酸酶参与了该蛋白的调
Inhibition－of－Cellular－Proliferation－by－Gleevec
The drug Gleevec (also known as imatinib mesylate or STI-571) was approved by the FDA in 2001 for the treatment of CML, chronic myeloid leukemia. Whil
Ghrelin:－Regulation－of－Food－Intake－and－Energy－Homeostasis
The somatotropic axis. The synthesis and release of growth hormone (GH) from the pituitary are controlled by the hypothalamic hormones GH-releasing ho
Transcription－Regulation－by－Methyltransferase－of－CARM1
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
Signal－Dependent－Regulation－of－Myogenesis－by－Corepressor－MITR
The differentiation of muscle cells is regulated by many factors, including the MyoD/MEF2 family of transcription factors. The MyoD/MEF2 dimer binds t
Regulation－of－Splicing－through－Sam68
While transcriptional regulation is often viewed as the most prevalent way extracellular signals to regulate gene expression, post-transcriptional reg
CARM1－and－Regulation－of－the－Estrogen－Receptor
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
Role－of－nicotinic－acetylcholine－receptors－in－the－regulation－of－apoptosis
Nicotinic acetylcholine receptors are essential for neuromuscular signaling and are also expressed in non-neuronal tissues, where their function is le