TheroleofFYVEfingerproteinsinvesicletransport

Eukaryotic cells take up constituents of the extra-cellular environment and regulate the cell-surface level of membrane proteins via a recycling system of membrane vesicles called endosomes. When cells are taking up elements from the cell-surface it is called endocytosis, and when they are delivered to the cell-surface it is called exocytosis. The transferrin receptor (TfR) is often employed as a model protein for st......阅读全文

The-role-of-FYVEfinger-proteins-in-vesicle-transport

Eukaryotic cells take up constituents of the extra-cellular environment and regulate the cell-surface level of membrane proteins via a recycling syste

Rab-GTPases-Mark-Targets-In-The-Endocytotic-Machinery

The eukaryotic cell contains compartments with distinct functions bounded by lipid bilayer membranes. The movement of membrane vesicles between these

Gammaaminobutyric-Acid-Receptor-Life-Cycle

Gamma-amino butyric acid (GABA) is an inhibitory neurotransmitter that acts at synapses through binding to ligand-gated ion channels, the GABA recepto

Endocytotic-role-of-NDK,-Phosphins-and-Dynamin

Reliable neurotransmitter release requires the presence of sufficent numbers of synaptic vesicles. The process of synaptic vesicle endocytosis (SVE) i

Cycling-of-Ran-in-nucleocytoplasmic-transport

Ran is a member of the Ras family of small GTPases. Ran is an important component of many crucial nucleocytoplasmic transport pathways. The cycling of

Role-of-Ran-in-mitotic-spindle-regulation

One of the central features of mitotic cell division is the formation of the spindle that segregates chromosomes into each daughter cell. Chromosomes

Noninvasive-Microelectrode-Ion-Flux-Estimation-Technique-(MIFE)-for-the...

Noninvasive Microelectrode Ion Flux Estimation Technique (MIFE) for the Study of the Regulation of Root Membrane Transport by Cyclic NucleotidesCh

Adrenal-chromaffin-granule-(chromaffin-vesicle)-preparation

Adrenal chromaffin granule (chromaffin vesicle) preparationIntroduction. This prep is adapted from the classic paper of Smith and Winkler (Smith AD; W

Purification-of-MBP-(maLTosebinding-proteins)-Fused-Proteins

Express fusion proteins as per the GST-fused protocol up to Step 7 (Day 3). All steps in protein purification should be done at 4° C unless otherwise

HSPA5基因突变与药物因子介绍

该基因编码的蛋白是热休克蛋白70(hsp70)家族的成员。局限于内质网(ER)内腔,参与ER中蛋白质的折叠和组装。由于这种蛋白质与许多ER蛋白质相互作用,它可能在监测蛋白质通过细胞的转运中起到关键作用。The protein encoded by this gene is a member of t

HSPA5基因编码功能及结构描述

该基因编码的蛋白是热休克蛋白70(hsp70)家族的成员。局限于内质网(ER)内腔,参与ER中蛋白质的折叠和组装。由于这种蛋白质与许多ER蛋白质相互作用,它可能在监测蛋白质通过细胞的转运中起到关键作用。The protein encoded by this gene is a member of t

与结直肠癌相关的HSPA5基因编码功能描述

该基因编码的蛋白是热休克蛋白70(hsp70)家族的成员。局限于内质网(ER)内腔,参与ER中蛋白质的折叠和组装。由于这种蛋白质与许多ER蛋白质相互作用,它可能在监测蛋白质通过细胞的转运中起到关键作用。The protein encoded by this gene is a member of t

与肾癌相关的HSPA5基因编码功能描述

该基因编码的蛋白是热休克蛋白70(hsp70)家族的成员。局限于内质网(ER)内腔,参与ER中蛋白质的折叠和组装。由于这种蛋白质与许多ER蛋白质相互作用,它可能在监测蛋白质通过细胞的转运中起到关键作用。The protein encoded by this gene is a member of t

HSPA5基因编码功能及结构描述

该基因编码的蛋白是热休克蛋白70(hsp70)家族的成员。局限于内质网(ER)内腔,参与ER中蛋白质的折叠和组装。由于这种蛋白质与许多ER蛋白质相互作用,它可能在监测蛋白质通过细胞的转运中起到关键作用。The protein encoded by this gene is a member of t

GOLGIVESICLE-PREPARATION-FROM-PEA-HYPOCOTYLS

PREPARE SOLUTIONS1. 0.25 M Sucrose Solution:Mix 40 g of sucrose (0.25M), 50 mL of 1M KH2PO4, pH 6.65 (0.1M), 2.5 mL of 1M MgCl2 (5 mM), and dH2O to 50

Role-of-Mitochondria-in-Apoptotic-Signaling

Mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein

实体肿瘤检测DYNC2H1基因介绍

这个基因编码一个大的细胞质动力蛋白,它参与纤毛的逆行运输,并在鞭毛内运输中发挥作用,这是纤毛/鞭毛组装所必需的过程。该基因的突变引起与原发性纤毛功能改变有关的异质性疾病谱,常涉及多指畸形、骨骼发生和多囊肾。选择性剪接导致编码不同蛋白质的多个转录变体。This gene encodes a large

实体肿瘤检测DYNC2H1基因介绍

这个基因编码一个大的细胞质动力蛋白,它参与纤毛的逆行运输,并在鞭毛内运输中发挥作用,这是纤毛/鞭毛组装所必需的过程。该基因的突变引起与原发性纤毛功能改变有关的异质性疾病谱,常涉及多指畸形、骨骼发生和多囊肾。选择性剪接导致编码不同蛋白质的多个转录变体。This gene encodes a large

DYNC2H1-基因突变与药物因子介绍

这个基因编码一个大的细胞质动力蛋白,它参与纤毛的逆行运输,并在鞭毛内运输中发挥作用,这是纤毛/鞭毛组装所必需的过程。该基因的突变引起与原发性纤毛功能改变有关的异质性疾病谱,常涉及多指畸形、骨骼发生和多囊肾。选择性剪接导致编码不同蛋白质的多个转录变体。[由RefSeq提供,2010年1月]This g

DYNC2H1基因编码功能及结构描述

这个基因编码一个大的细胞质动力蛋白,它参与纤毛的逆行运输,并在鞭毛内运输中发挥作用,这是纤毛/鞭毛组装所必需的过程。该基因的突变引起与原发性纤毛功能改变有关的异质性疾病谱,常涉及多指畸形、骨骼发生和多囊肾。选择性剪接导致编码不同蛋白质的多个转录变体。[由RefSeq提供,2010年1月]This g

DYNC2H1基因突变与药物因子介绍

这个基因编码一个大的细胞质动力蛋白,它参与纤毛的逆行运输,并在鞭毛内运输中发挥作用,这是纤毛/鞭毛组装所必需的过程。该基因的突变引起与原发性纤毛功能改变有关的异质性疾病谱,常涉及多指畸形、骨骼发生和多囊肾。选择性剪接导致编码不同蛋白质的多个转录变体。[由RefSeq提供,2010年1月]This g

光合电子传递-(photosynthetic-electron-transport)

光合作用中,受光激发推动的电子从 H2 O到辅酶Ⅱ( NADP )的传递过程。光合色素吸收光能后,把能量聚集到反应中心——一种特殊状态的叶绿素 a分子,引起电荷分离和光化学反应。一方面将水氧化,放出氧气;另一方面把电子传递给辅酶Ⅱ( NADP ),将它还原成 NADPH,其间经过一系列中间(电

MultiDrug-Resistance-Factors

Cancer cells resistant to a diverse set of hydrophobic drugs are known as MDR cells (multidrug-resistant). Large membrane proteins overproduced in MDR

ABCC3基因编码功能及结构描述

该基因编码的蛋白是ATP结合盒(ABC)转运蛋白的超家族成员。ABC蛋白通过细胞外膜和细胞内膜转运各种分子。ABC基因分为7个不同的亚家族(abc1,mdr/tap,mrp,ald,oabp,gcn20,white)。这种蛋白是MRP亚家族的一员,它与多药耐药有关。这种蛋白质的具体功能尚未确定;然而

ABCC3基因突变与药物因子介绍

该基因编码的蛋白是ATP结合盒(ABC)转运蛋白的超家族成员。ABC蛋白通过细胞外膜和细胞内膜转运各种分子。ABC基因分为7个不同的亚家族(abc1,mdr/tap,mrp,ald,oabp,gcn20,white)。这种蛋白是MRP亚家族的一员,它与多药耐药有关。这种蛋白质的具体功能尚未确定;然而

与肺癌相关的ABCC3基因编码功能描述

该基因编码的蛋白是ATP结合盒(ABC)转运蛋白的超家族成员。ABC蛋白通过细胞外膜和细胞内膜转运各种分子。ABC基因分为7个不同的亚家族(abc1,mdr/tap,mrp,ald,oabp,gcn20,white)。这种蛋白是MRP亚家族的一员,它与多药耐药有关。这种蛋白质的具体功能尚未确定;然而

The-Role-of-Eosinophils-in-the-Chemokine-Network-of-Allergy

The inflammatory response associated with asthma is characterized by the recruitment of eosinophils from the bronchial microcirculation in response to

Structure-of-Mitochondria

The cytoplasm of nearly all eukaryotic cells contain mitochondria, although there is at least one exception, the protist Chaos (Pelomyxa) carolinensis

Mitochondria-Structure-and-Function--Theoretical-Details

Mitochondria Structure and Function - Theoretical DetailsIn an attempt to be concise and understandable, introductory level courses and textbooks freq

线粒体的结构与功能

In an attempt to be concise and understandable, introductory level courses and textbooks frequently present concepts that are technically correc