RoleofPPARgammaCoactivatorsinObesityandThermogenesis
Nuclear hormone receptors are transcription factors that bind DNA and regulate transcription in a ligand-dependent manner. PPAR-gamma is a member of this gene family that is activated by fatty acids and thiazolidinedione drugs that plays a role in insulin sensitivity and adipogenesis (See Visceral Fat Deposits and the Metabolic Syndrome pathway). Like PPAR-alpha and other members of this gene family, PPAR-gamma activ......阅读全文
Role－of－PPARgamma－Coactivators－in－Obesity－and－Thermogenesis
Nuclear hormone receptors are transcription factors that bind DNA and regulate transcription in a ligand-dependent manner. PPAR-gamma is a member of t
PPARG基因突变因子与药物介绍
该基因编码核受体过氧化物酶体增殖激活受体（ppar）亚家族的一个成员。ppar与维甲酸x受体（rxrs）形成异二聚体，这些异二聚体调节各种基因的转录。已知三种ppar亚型：pparα、pparδ和pparγ。该基因编码的蛋白是pparγ，是脂肪细胞分化的调节因子。此外，pparγ还与许多疾病的病理学
核受体信号通路相关因子PPARG
该基因编码核受体过氧化物酶体增殖激活受体（ppar）亚家族的一个成员。ppar与维甲酸x受体（rxrs）形成异二聚体，这些异二聚体调节各种基因的转录。已知三种ppar亚型：pparα、pparδ和pparγ。该基因编码的蛋白是pparγ，是脂肪细胞分化的调节因子。此外，pparγ还与许多疾病的病理学
PPARG基因编码的功能和结构描述
该基因编码核受体过氧化物酶体增殖激活受体（ppar）亚家族的一个成员。ppar与维甲酸x受体（rxrs）形成异二聚体，这些异二聚体调节各种基因的转录。已知三种ppar亚型：pparα、pparδ和pparγ。该基因编码的蛋白是pparγ，是脂肪细胞分化的调节因子。此外，pparγ还与许多疾病的病理学
Visceral－Fat－Deposits－and－the－Metabolic－Syndrome
Obesity is associated with many adverse health effects, including an increased risk of diabetes and heart disease. The combined condition of obesity,
Nature：脂肪与肌肉之间的联系
专题：Nature报道 本期封面所示为棕色脂肪，在其中，PRDM16的表达被shRNA抑制，肌肉细胞标记为红色，脂肪细胞和其他细胞类型标记为蓝色核。封面美术：Eric Smith。 人体中有两种类型的脂肪组织：一种是棕色脂肪，主要功能是燃烧卡路里，产生身体所需热量；另一种
Role－of－Mitochondria－in－Apoptotic－Signaling
Mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein
研究表明棕色脂肪有助于减肥
加拿大渥太华大学科学家使用肌肉干细胞，在实验室老鼠身上制造出可以燃烧卡路里的棕色脂肪，有助于治疗加拿大人日渐普遍的肥胖症。据介绍，棕色脂肪是哺乳类动物身体制造的两种脂肪之一。棕色脂肪与白色脂肪相比，属于好脂肪，因为它属于发热组织，能够燃烧掉存在白色脂肪中的卡路里。棕色脂肪多在新生婴儿及冬眠动物体内发
Transcription－Regulation－by－Methyltransferase－of－CARM1
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
The－Role－of－Eosinophils－in－the－Chemokine－Network－of－Allergy
The inflammatory response associated with asthma is characterized by the recruitment of eosinophils from the bronchial microcirculation in response to
Endocytotic－role－of－NDK,－Phosphins－and－Dynamin
Reliable neurotransmitter release requires the presence of sufficent numbers of synaptic vesicles. The process of synaptic vesicle endocytosis (SVE) i
Role－of－Ran－in－mitotic－spindle－regulation
One of the central features of mitotic cell division is the formation of the spindle that segregates chromosomes into each daughter cell. Chromosomes
CARM1－and－Regulation－of－the－Estrogen－Receptor
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
能量代谢测量技术—肠道菌群研究案例（二）
典型案例3 Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation. Yongguo Li, Katharina Schnabl, Sarah-Madeleine Gabler, et al.
Ion－Channels－and－Their－Functional－Role－in－Vascular－Endothelium
Endothelial cells (EC) form a multifunctional signal-transducing surface that performs different tasks dependent on its localization in the vessel tre
Role－of－nicotinic－acetylcholine－receptors－in－the－regulation－of－apoptosis
Nicotinic acetylcholine receptors are essential for neuromuscular signaling and are also expressed in non-neuronal tissues, where their function is le
Role－of－Erk5－in－Neuronal－Survival
Axons extend significant distances to innervate target tissues. At the site of innervation, target tissues release neurotrophins including NGF, BDNF a
Role－of－Tob－in－Tcell－activation
Regulation of T cell activation is a crucial component of balanced functioning of the immune system. If the T cell response is too great and activatio
Role－of－arrestins－in－the－activation－and－targeting－of－MAP－kinases
The binding of ?-arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kinase activation complex using ?-arrestin as a scaffold, with sub
Role－of－Parkin－in－the－UbiquitinProteasomal－Pathway
The motor defects of Parkinson's disease are related to the loss of dopaminergic neurons in specific brain regions. Examination of these neurons i
Adiponectin－Replenishment－Ameliorates－ObesityRelated－Hypertension（四）
Discussion The major findings of the present study were the following: (1) adiponectin supplementation reduced the SBP of spontaneously hyperte
Obesity：吃货更瘦？！是真的吗？
试想一下你是一个资深吃货，即一个爱冒险的食客，这常常和个人嗜好吃美食且过量吃东西密切相关；然而近日，一项来自康奈尔大学食品研究实验室的最新研究表明，我们往往会认为资深吃货应该是比较肥胖且体重较重的个体，然而实际上恰恰相反，资深吃货往往体重较轻，而且相比并不爱冒险饮食的食客他们更加健康一些。 相
Adiponectin－Replenishment－Ameliorates－ObesityRelated－Hypertension（二）
Methods Animal and Animal Treatment KKAy male mice were purchased from Japan CLEA (Tokyo, Japan). This strain is a cross between black KK fema
Adiponectin－Replenishment－Ameliorates－ObesityRelated－Hypertension（六）
Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor
Adiponectin－Replenishment－Ameliorates－ObesityRelated－Hypertension（五）
Perspectives Obesity is closely associated with hypertension. The mechanisms underlying hypertension in obesity, however, have not been fully c
Adiponectin－Replenishment－Ameliorates－ObesityRelated－Hypertension（一）
Adiponectin Replenishment Ameliorates Obesity-Related Hypertension作者：Koji Ohashi; Shinji Kihara; Noriyuki Ouchi; Masahiro Kumada; Koichi Fujita; Aki
Adiponectin－Replenishment－Ameliorates－ObesityRelated－Hypertension（三）
Results Adiponectin Supplementation Decreases Blood Pressure in Obese Diabetic KKAy Mice We studied genetically obese KKAy mice, which develop
Role－of－MAL－in－RhoMediated－Activation－of－SRF
Serum response factor (SRF) is a transcription factor, which binds to a serum response element (SRE) associated with a variety of genes including (i)i
Role－of－EGF－Receptor－Transactivation－by－GPCRs－in－Cardiac－Hypertrophy
One of responses to increased blood pressure is cardiac hypertrophy through increased size of ventricular myocardial cells leading to increased thickn
The－role－of－FYVEfinger－proteins－in－vesicle－transport
Eukaryotic cells take up constituents of the extra-cellular environment and regulate the cell-surface level of membrane proteins via a recycling syste