MechanismsoftranscriptionalrepressionbyDNAmethylation
Tumorigenesis is known to be a multistep process in which defects in various cancer genes accumulate. Epigenetic modifications, most importantly DNA methylation events, are frequently involved in transcriptional changes in both tumor suppressor genes and oncogenes. Methylation of cytosine at CpG dinucleotides is a common feature of a higher eukaryotic genomes. DNA methylation in the promoter regions of genes is gener......阅读全文
Mechanisms－of－transcriptional－repression－by－DNA－methylation
Tumorigenesis is known to be a multistep process in which defects in various cancer genes accumulate. Epigenetic modifications, most importantly DNA m
Repression－of－Pain－Sensation－by－the－Transcriptional－Regulator－DREAM
The molecular events that lead to the perception of pain are a key research field in medicine and drug discovery. The opioid receptors modulate pain s
Sumoylation－by－RanBP2－Regulates－Transcriptional－Repression
Current data indicates that nuclear pore complex (NPC) RanBP2 (SUMO E3 ligase) protein sumoylates Mdm2 and HDAC proteins during nuclear translocation.
Overview－of－telomerase－RNA－component－gene－hTerc－Transcriptional－Regulation
Telomerase is an enzyme which replicates the terminal sequences of eukaryotic chromosomes, namely the telomeres. Cells which have an unlimited replica
The－PRC2－Complex－Sets－Long－杢erm－Gene－Silencing－Through－Modification
Packaging of DNA into chromatin allows the cell to store its genetic information efficiently and has an important role in regulating gene expression.
Basic－Mechanisms－of－SUMOylation
Like ubiquitin, SUMO (small ubiquitin-related modifier) proteins are small protein tags that are conjugated to proteins to modify their function. The
The－informationprocessing－pathway－at－the－IFNbeta－enhancer
The packaging of eukaryotic DNA into nucleosomes inhibits the access of factors to DNA and results in the repression of transcription, replication and
SETDB1基因编码的功能和结构描述
这个基因编码一个组蛋白甲基转移酶，它调节组蛋白甲基化、基因沉默和转录抑制。鉴于基因沉默和转录功能障碍可能在亨廷顿病的发病机制中起作用，该基因已被确定为亨廷顿病治疗的靶点已经描述了该基因的选择性剪接转录变体。This gene encodes a histone methyltransferase w
SETDB1基因突变因子与药物介绍
这个基因编码一个组蛋白甲基转移酶，它调节组蛋白甲基化、基因沉默和转录抑制。鉴于基因沉默和转录功能障碍可能在亨廷顿病的发病机制中起作用，该基因已被确定为亨廷顿病治疗的靶点已经描述了该基因的选择性剪接转录变体。[由RefSeq提供，2011年6月]This gene encodes a histone
Protein－arginine－methylation
Typical modification sites: RGG box or RXR sequence motifs R-arginine, G-glycine,X-any aminoacid.Enzymes catalysing protein arginine methylation: PRMT
Methylation－Specific－PCR
Methylation Specific PCRProtocol written by James Herman*Methylation Specific PCR (MSP) is a simple rapid and inexpensive method to determine the meth
Regulation－of－transcriptional－activity－by－PML
The PML nuclear bodies are ring-shaped nuclear substructures associated with the regulation of transcription, transformation, cell growth, and apoptos
CARM1－and－Regulation－of－the－Estrogen－Receptor
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
METS－affect－on－Macrophage－Differentiation
Terminal differentiation of cells is often accompanied by repression of cellular proliferation, suggesting that there is a mechanism by which these ce
Methylation－of－Fatty－Acids－(Kropinski－Method)
Methylation of Fatty Acids (Kropinski Method)OBJECTIVE:To methylate fatty acids in whole cells or lipopolysaccharide.REAGENTS :Methanol-Hydrochloride
Transcriptional－activation－of－dbpb－from－mRNA
Endothelial cells respond to treatment with the protease thrombin with increased secretion of the PDGF B-chain. This activation occurs at the transcri
MethPrimer－－Design－Primers－for－Methylation－PCRs
Welcome to MethPrimer MethPrimer is a program for designing bisulfite-conversion-based Methylation PCR Primer. Currently, it can design primers for tw
人工转录因子的部件——人类锌指结构1
Human zinc fingers as building blocks in the construction of artificial transcription factorsKwang-Hee Bae1, 4, Young Do Kwon1, 2, 4, Hyun-Chul Shin1,
Signal－Dependent－Regulation－of－Myogenesis－by－Corepressor－MITR
The differentiation of muscle cells is regulated by many factors, including the MyoD/MEF2 family of transcription factors. The MyoD/MEF2 dimer binds t
HDAC7基因突变与药物因子介绍
组蛋白在转录调控、细胞周期进展和发育事件中起着关键作用。组蛋白乙酰化/去乙酰化改变染色体结构并影响转录因子对dna的获取。该基因编码的蛋白质与组蛋白脱乙酰酶家族成员具有序列同源性。该基因与小鼠hdac7基因同源，其蛋白通过转录辅压子smrt介导抑制作用。另外，已经发现该基因编码不同亚型的剪接转录变体
HDAC7基因编码功能及结构描述
组蛋白在转录调控、细胞周期进展和发育事件中起着关键作用。组蛋白乙酰化/去乙酰化改变染色体结构并影响转录因子对dna的获取。该基因编码的蛋白质与组蛋白脱乙酰酶家族成员具有序列同源性。该基因与小鼠hdac7基因同源，其蛋白通过转录辅压子smrt介导抑制作用。另外，已经发现该基因编码不同亚型的剪接转录变体
HDAC7基因编码功能及结构描述
组蛋白在转录调控、细胞周期进展和发育事件中起着关键作用。组蛋白乙酰化/去乙酰化改变染色体结构并影响转录因子对dna的获取。该基因编码的蛋白质与组蛋白脱乙酰酶家族成员具有序列同源性。该基因与小鼠hdac7基因同源，其蛋白通过转录辅压子smrt介导抑制作用。另外，已经发现该基因编码不同亚型的剪接转录变体
RNAi术语表
RNAi GlossaryDicer - Dicer is a member of the RNase III family of nucleases that specifically cleave double-stranded RNAs. Dicer processes long dsRNA
Snf1－in－Yeast－Glucose－Repression/Derepression
The Snf1 protein kinase is a central component of the signalling pathway for glucose repression in yeast. On removal of glucose, gene repression is re
Transcription－Regulation－by－Methyltransferase－of－CARM1
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
RNAi相关的名词解释[英文]
Argonaute - A family of proteins containing multiple domains and involved in RNA interference (RNAi). Argonatue is the main component of RNAi effector
Overview－of－telomerase－protein－component－gene－hTert－Transcriptional
Telomerase is an enzyme which replicates the terminal sequences of eukaryotic chromosomes, namely the telomeres. Cells which have an unlimited replica
CBFA2T3基因突变与药物因子介绍
该基因编码髓系易位基因家族的一个成员，该家族与DNA结合转录因子相互作用，并招募一系列共加压因子以促进转录抑制。T（16；21）（q24；q22）易位是急性髓性白血病较少见的核型异常之一。易位产生一个由RUNT相关转录因子1基因的5’-区与该基因的3’-区融合构成的嵌合基因。这个基因也是一个假定的乳
CABFA2T3基因编码功能及结构描述
该基因编码髓系易位基因家族的一个成员，该家族与DNA结合转录因子相互作用，并招募一系列共加压因子以促进转录抑制。T（16；21）（q24；q22）易位是急性髓性白血病较少见的核型异常之一。易位产生一个由RUNT相关转录因子1基因的5’-区与该基因的3’-区融合构成的嵌合基因。这个基因也是一个假定的乳
与白血病相关的CBFA2T3基因编码功能描述
该基因编码髓系易位基因家族的一个成员，该家族与DNA结合转录因子相互作用，并招募一系列共加压因子以促进转录抑制。T（16；21）（q24；q22）易位是急性髓性白血病较少见的核型异常之一。易位产生一个由RUNT相关转录因子1基因的5’-区与该基因的3’-区融合构成的嵌合基因。这个基因也是一个假定的乳