E2F1DestructionPathway
E2F-1 is a transcription factor that regulates the expression of genes involved in the cell cycle and that is involved in progression of the cell cycle from G1 into S phase. Over-expression of E2F-1 can induce cellular transformation and its under-expression can repress apoptosis. Association with the tumor suppressor Rb represses E2F-1 activity, and this repression is relieved when the cdk2/cyclin E complex at the G......阅读全文
FAS－signaling－pathway－(－CD95－)
Receptors in the TNF receptor family are associated with the induction of apoptosis, as well as inflammatory signaling. The Fas receptor (CD95) mediat
SODD/TNFR1－Signaling－Pathway
The tumor necrosis factor (TNF) receptor superfamily contains several members with homologous cytoplasmic domains known as death domains (DD). The int
p38－MAPK－Signaling－Pathway
p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are deli
D4GDI－Signaling－Pathway
D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras related Rho Family of GTPases. Since the rho GTPases promote cytoskeletal and m
Aspirin－Blocks－Signaling－Pathway－Involved－in－Platelet－Activation
Activation of the protease-activated GPCRs in platelets contributes to platelet activation in clotting. The protease-activated receptors PAR1 and PAR4
Signaling－Pathway－from－GProtein－Families
G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP. In contrast Gai-coupled receptors inhibit AC and so reduce cA
Rgt1－in－Yeast－Glucose－Induction－Pathway
Yeast sense glucose in their environment and alter gene expression to match their nutritional needs. In a glucose-rich environment, glycolysis is acti
IL22－Soluble－Receptor－Signaling－Pathway
IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surfa
碳4途径（C4pathway）
亦称四碳二羧酸循环（ C4 -dicarboxylic cycle）。光合碳同化的辅助途径。起源于热带及亚热带的一些植物，在其光合作用的暗反应中，二氧化碳首次被固定的接受体是磷酸烯醇式丙酮酸（ PEP）。在 PEP羧化酶催化下形成 C4 -羧酸——草酰乙酸。在 NADP-苹果酸脱氢酶催化下，还原为苹
Lowdensity－lipoprotein－(LDL)－pathway－during－atherogenesis
Low-density lipoprotein (LDL) is a plasma lipoprotein particle whose lipid component includes cholesterol and triglycerides and is commonly referred t
IL10－Antiinflammatory－Signaling－Pathway
IL-10 is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by
Skeletal－muscle－hypertrophy－is－regulated－via－AKT/mTOR－pathway
Skeletal muscle atrophies with disuse while with increased use and increased load skeletal muscle exhibits hypertrophy, with an increase in the size o
The－informationprocessing－pathway－at－the－IFNbeta－enhancer
The packaging of eukaryotic DNA into nucleosomes inhibits the access of factors to DNA and results in the repression of transcription, replication and
NO2dependent－IL－12－Pathway－in－NK－cells
Macrophages and NK cells help provide innate immunity against infection by intracellular parasites and communicate with each other to regulate this pr
RasIndependent－pathway－in－NK－cellmediated－cytotoxicity
NK (natural killer) cells are lymphocytes distinct from B and T cells that induce perforin-mediated lysis of tumor cells and virus-infected cells. NK
gSecretase－mediated－ErbB4－Signaling－Pathway
The HER4/erbB4 receptor tyrosine kinase is a member of the EGF1 receptor family. HER4 is a receptor for the neuregulins (NRGs), a family of growth and
Erk1/Erk2－Mapk－Signaling－pathway
The p44/42 MAP Kinase pathway consists of a protein kinase cascade linking growth and differentiation signals with transcription in the nucleus. Growt
上海交大Nature子刊发表肝癌新成果
来自上海交通大学医学院的研究人员在新研究中证实，POH1去泛素化及稳定E2F1促进了肿瘤形成。这一研究发现发布在10月29日的《自然通讯》（Nature Communications）杂志上。 文章的通讯作者是上海交通大学医学院的刘永忠（Yongzhong Liu）博士。其主要研究方向包括肿瘤
Pathway－Genomics付款4百万美元用于回扣指控
分析测试百科网讯 政府机构近日宣布，Pathway Genomics已同意支付约4百万美元用于解决美国司法部的指控，指控其向医生和医生组织非法支付回扣以交换转诊病人。 美国律师Laura Duffy在声明中说道：“给医疗服务提供者回扣用于换取病人的转诊削弱医师的医疗判断，并且利用了患者的信任。
Novus助力HIPPO信号通路研究
Hippo信号通路是近年来在果蝇中研究发现的一个高度保守的生长控制信号通路，其对器官大小及细胞增殖和凋亡都具有关键的调节作用。该通路由多种抑癌基因及一种候选癌基因组成，此通路的失活或者异常表达在动物实验中参与多种疾病的发生。 Hippo通路的生物学效应有：调控器官体积，保持细胞增殖凋亡
GADD34mediated－Dephosphorylatoin－of－eIF2a－in－Stress－Response－Pathway
NON-Clickable Image Translation initiation is inhibited in cells exposed to different stressful conditions. The phosphorylation of the aContributor:RE
Angiotensin－II－mediated－activation－of－JNK－Pathway－via－Pyk2－dependent
Ang II binding to AT1-R triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to the Pyk2 and further to the small G prote
cdc25－and－chk1－Regulatory－Pathway－in－response－to－DNA－damage
Cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells i
Interleukin6－Induced－Acute－Phenotypic－Microenvironment－Promote...（一）
Interleukin-6 Induced Acute Phenotypic Microenvironment Promotes Th1 Anti-Tumor ImmunityTing Xue1, Ping Liu1, Yong Zhou2, Kun Liu1, Li Yang2, Robert L
Nitrogendepedent－regulation－of－Rtg1－and－Rtg3－in－TOR－pathway
Many key signaling molecules are conserved from yeast to man. mTOR is a protein kinase involved in nutrient and growth factor signaling in humans that
IL12－and－Stat4－Dependent－Signaling－Pathway－in－Th1－Development
Interleukin-12 (IL-12) promotes cell-mediated immunity by inducing Th1 cell differentiation and activation of both T cells and NK cells. Dendritic cel
青岛大学Nature子刊发布miRNA研究新发现
来自青岛大学、中国医学科学院的研究人员证实，E2F1依赖性的miR-421通过靶向Pink1调控了线粒体破裂和心肌梗塞。这一研究发现发布在7月17日的《自然通讯》（Nature Communications）杂志上。青岛大学转化医学研究院院长李培峰（Pei-Feng Li）教授及中国医学科学院的
以生物路径丛(Pathway－Cluster)概念从事复杂疾病之基因分析1
在后基因体时代，基因芯片 (microarray) 的出现让研究人员得以宏观的视野来探讨分子机转。在许多努力和资源投入到寻找新的疾病基因后，许多单基因疾病已成功地找出致病基因。然而，在复杂疾病 (例如高血压、糖尿病及一些常见癌症) 的研究上，收获却不如期待中的丰富。大多数复杂疾病的研究中
以生物路径丛(Pathway－Cluster)概念从事复杂疾病之基因分析2
结论 这一年来华联快讯介绍基因芯片在各领域的应用，在年末我们希望藉这期简短的介绍，带大家认识生物路径丛的概念，拓展基因芯片数据在构建与表型相关之分析模块的可能方向。面对复杂疾病或表型的异质与多源性，我们预期这个生物路径丛概念的运用应能帮助简化复杂疾病或表型的面向，而有效定位疾病或表型，并协助找
Phosphorylation－of－MEK1－by－cdk5/p35－down－regulates－the－MAP－kinase－pathway
Map kinases transduce responses to extracellular signals by a variety of routes, and communicate with other pathways through extensive crosstalk netwo