RegulationofMAPKinasePathwaysThroughDualSpecificityPhosphatases
Mitogen-activated protein (MAP) kinases are important players in signal transduction pathways activated by a range of stimuli and mediate a number of physiological and pathological changes in cell function. There are three major subgroups in the MAPK family: ERK, p38, and JNK/SAPK. ERK is activated mainly by mitogenic stimuli, whereas p38 and JNK/SAPK are activated mainly by stress stimuli or inflammatory cytokines. ......阅读全文
Regulation－of－MAP－Kinase－Pathways－Through－Dual－Specificity－Phosphatases
Mitogen-activated protein (MAP) kinases are important players in signal transduction pathways activated by a range of stimuli and mediate a number of
Human－Cytomegalovirus－and－Map－Kinase－Pathways
To replicate in the host cell, viruses commandeer cellular signaling pathways. Cytomegalovirus (CMV) is a DNA virus with that is widespread in the pop
DUSP2基因突变与药物因子介绍
该基因编码的蛋白是双特异性蛋白磷酸酶亚家族的一员。这些磷酸酶通过磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基的去磷酸化使其靶激酶失活它们负性调节丝裂原活化蛋白激酶超家族（MAPK/ERK，SAPK/JNK，p38）的成员，这些成员与细胞增殖和分化有关双特异性磷酸酶家族的不同成员对不同的MAP激酶、不同的组织分
DUSP2基因编码功能及结构描述
该基因编码的蛋白是双特异性蛋白磷酸酶亚家族的一员。这些磷酸酶通过磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基的去磷酸化使其靶激酶失活它们负性调节丝裂原活化蛋白激酶超家族（MAPK/ERK，SAPK/JNK，p38）的成员，这些成员与细胞增殖和分化有关双特异性磷酸酶家族的不同成员对不同的MAP激酶、不同的组织分
DUSP6－基因突变与药物因子介绍
该基因编码的蛋白是双特异性蛋白磷酸酶亚家族的成员。这些磷酸酶通过磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基的去磷酸化来灭活其靶激酶。负性调节有丝分裂原激活蛋白（MAP）激酶超家族成员（MAPK/ERK，SAPK/JNK，p38），与细胞增殖和分化有关。双特异性磷酸酶家族的不同成员对不同的MAP激酶、不同的组
DUSP6基因编码功能及结构描述
该基因编码的蛋白是双特异性蛋白磷酸酶亚家族的成员。这些磷酸酶通过磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基的去磷酸化来灭活其靶激酶。负性调节有丝分裂原激活蛋白（MAP）激酶超家族成员（MAPK/ERK，SAPK/JNK，p38），与细胞增殖和分化有关。双特异性磷酸酶家族的不同成员对不同的MAP激酶、不同的组
DUSP4－基因突变与药物因子介绍
该基因编码的蛋白是双特异性蛋白磷酸酶亚家族的一员这些磷酸酶通过磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基的去磷酸化使其靶激酶失活。它们负性调节丝裂原活化蛋白激酶超家族（mapk/erk，sapk/jnk，p38）的成员，这些成员与细胞增殖和分化有关。双特异性磷酸酶家族的不同成员对不同的MAP激酶、不同的组织
DUSP4基因编码功能及结构描述
该基因编码的蛋白是双特异性蛋白磷酸酶亚家族的一员这些磷酸酶通过磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基的去磷酸化使其靶激酶失活。它们负性调节丝裂原活化蛋白激酶超家族（mapk/erk，sapk/jnk，p38）的成员，这些成员与细胞增殖和分化有关。双特异性磷酸酶家族的不同成员对不同的MAP激酶、不同的组织
Sprouty－regulation－of－tyrosine－kinase－signals
Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors,
TNF/Stress－Related－Signaling
TNF acts on several different signaling pathways through two cell surface receptors, TNFR1 and TNFR2 (See TNFR1 and TNFR2 Signaling Pathways) to regul
Regulation－of－Splicing－through－Sam68
While transcriptional regulation is often viewed as the most prevalent way extracellular signals to regulate gene expression, post-transcriptional reg
PPM1D基因编码的功能和结构描述
该基因编码的蛋白是ser/thr蛋白磷酸酶pp2c家族的成员。pp2c家族成员是细胞应激反应途径的负调控因子。该基因的表达在不同的环境胁迫下以p53依赖的方式诱导。在肿瘤抑制蛋白tp53/p53诱导下，这种磷酸酶负性调节p38-map激酶mapk/p38的活性，从而降低p53的磷酸化，进而抑制p53
PPM1D基因突变因子与药物介绍
该基因编码的蛋白是ser/thr蛋白磷酸酶pp2c家族的成员。pp2c家族成员是细胞应激反应途径的负调控因子。该基因的表达在不同的环境胁迫下以p53依赖的方式诱导。在肿瘤抑制蛋白tp53/p53诱导下，这种磷酸酶负性调节p38-map激酶mapk/p38的活性，从而降低p53的磷酸化，进而抑制p53
Map－Kinase－Inactivation－of－SMRT－Corepressor
Corepressors are coregulators that interact with transcriptional silencers in a variety of pathways such as cell proliferation, differentiation and ap
RasIndependent－pathway－in－NK－cellmediated－cytotoxicity
NK (natural killer) cells are lymphocytes distinct from B and T cells that induce perforin-mediated lysis of tumor cells and virus-infected cells. NK
PTEN－dependent－cell－cycle－arrest－and－apoptosis
PTEN is a tumor suppressor gene. Recombinant PTEN is capable of dephosphorylating phosphatidylinositol 3,4,5-triphosphate[PI(3,4,5)P3], the product of
Phosphorylation－of－MEK1－by－cdk5/p35－down－regulates－the－MAP－kinase－pathway
Map kinases transduce responses to extracellular signals by a variety of routes, and communicate with other pathways through extensive crosstalk netwo
Integrin－Signaling－Pathway
Integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals in response to the extracellular ma
与肺癌相关的MAP2K7基因编码功能描述
该基因编码的蛋白是一种双特异性蛋白激酶，属于MAP激酶激酶家族。这种激酶专门激活MAPK8/JNK1和MAPK9/JNK2，这种激酶本身被包括MAP3K1/MEKK1、MAP3K2/MEKK2、MAP3K3/MEKK5和MAP4K2/GCK的MAP激酶激酶激酶磷酸化并激活。这种激酶参与调节细胞对促炎
MAP2K7基因突变与药物因子介绍
该基因编码的蛋白是一种双特异性蛋白激酶，属于MAP激酶激酶家族。这种激酶专门激活MAPK8/JNK1和MAPK9/JNK2，这种激酶本身被包括MAP3K1/MEKK1、MAP3K2/MEKK2、MAP3K3/MEKK5和MAP4K2/GCK的MAP激酶激酶激酶磷酸化并激活。这种激酶参与调节细胞对促炎
MAP2K7基因编码功能及结构描述
该基因编码的蛋白是一种双特异性蛋白激酶，属于MAP激酶激酶家族。这种激酶专门激活MAPK8/JNK1和MAPK9/JNK2，这种激酶本身被包括MAP3K1/MEKK1、MAP3K2/MEKK2、MAP3K3/MEKK5和MAP4K2/GCK的MAP激酶激酶激酶磷酸化并激活。这种激酶参与调节细胞对促炎
MAP2K7与癌症相关的基因编码功能描述
该基因编码的蛋白是一种双特异性蛋白激酶，属于MAP激酶激酶家族。这种激酶专门激活MAPK8/JNK1和MAPK9/JNK2，这种激酶本身被包括MAP3K1/MEKK1、MAP3K2/MEKK2、MAP3K3/MEKK5和MAP4K2/GCK的MAP激酶激酶激酶磷酸化并激活。这种激酶参与调节细胞对促炎
NFkB－activation－by－Nontypeable－Hemophilus－influenzae
The role of Hemophilus influenzae in ear infections and chronic obstructive pulmonary disease includes the induction of an inflammatory response throu
Bioactive－Peptide－Induced－Signaling－Pathway
Many different peptides act as signaling molecules, including the proinflammatory peptide bradykinin, the protease enzyme thrombin, and the blood pres
Nerve－growth－factor－pathway－(NGF)
Nerve growth factor (NGF) is one of a family of neurotrophins that induce the survival and proliferation of neurons. In cell culture NGF induces the f
Oxidative－Stress－Induced－Gene－Expression－Via－Nrf2
Reactive oxygen species (ROS) can damage biological macromolecules and are detrimental to cellular health. Electrophilic compounds, xenobiotics and an
p38－MAPK－Signaling－Pathway
p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are deli
Role－of－PI3K－subunit－p85－in－regulation－of－Actin－Organization
Migration of cells is involved in essential functions such as development, invasiveness of cancer cells, leukocyte movement toward chemotactic signals
MAP2K3基因突变与药物因子介绍
该基因编码的蛋白是一种双特异性蛋白激酶，属于MAP激酶家族。这种激酶被有丝分裂和环境胁迫激活，参与MAP激酶介导的信号级联它磷酸化，从而激活MAPK14/p38 MAPK这种激酶可被胰岛素激活，是葡萄糖转运蛋白表达所必需的RAS癌基因的表达导致该激酶活性形式的积累，从而导致MAPK14的组成性激活，
MAP2K3基因编码功能及结构描述
该基因编码的蛋白是一种双特异性蛋白激酶，属于MAP激酶家族。这种激酶被有丝分裂和环境胁迫激活，参与MAP激酶介导的信号级联它磷酸化，从而激活MAPK14/p38 MAPK这种激酶可被胰岛素激活，是葡萄糖转运蛋白表达所必需的RAS癌基因的表达导致该激酶活性形式的积累，从而导致MAPK14的组成性激活，