BasicmechanismofactionofPPARa,PPARb(d)andPPARgandeffects

Basic－mechanism－of－action－of－PPARa,－PPARb(d)－and－PPARg－and－effects

Similar to other nuclear hormone receptores, PPAR acts as a ligand activated transcription factor. Upon binding fatty acids or hypolipidemic drugs, PP

Anthrax－Toxin－Mechanism－of－Action

One of the key causes of anthrax virulence is the production of three specific factors by the gram-positive spore forming bacteria Bacillus anthracis.

Mechanism－of－Gene－Regulation－by－Peroxisome－Proliferators－via－PPARa(alpha)

The most recognized mechanism by which peroxisome proliferators regulated gene expresssion is through a PPAR/RXR heterodimeric complex binding to a pe

Calcium－Signaling－by－HBx－of－Hepatitis－B－virus

Hepatitis B is a small DNA virus that contains only 4 open reading frames in its genome. Three of these ORFs have been identified as the envelope, cap

Presenilin－action－in－Notch－and－Wnt－signaling

 Presenilin-1 (PS1) is associated with gamma secretase activity that cleaves amyloid precursor protein (APP) and is implicated in Alzheimer's dis

Mechanism－of－Acetaminophen－Activity－and－Toxicity

Acetaminophen is one of the worlds most commonly used drugs, used for the treatment of pain and fever. Like other NSAIDs (non-steroidal anti-inflammat

Mechanism－of－Protein－Import－into－the－Nucleus

Nuclear pore complexes (NPCs) are large proteinaceous assemblies that provide the only known portals for exchanging macromolecules between the nucleus

Basic－PCR

实验概要The  following basic protocol serves as a general guideline and a starting  point for any PCR amplification. Optimal reaction conditions (incubati

Metabolomics:肥胖、糖尿病、心血管病等代谢性疾病治疗新途径

　　代谢性疾病,如:肥胖、糖尿病、心血管病等，已在全球范围内造成重大健康危害。巨噬细胞作为先天免疫细胞，广泛存于体内各种组织。代谢性疾病微环境信号，如：炎症、氧化压力、营养过剩等，影响巨噬细胞代谢，而巨噬细胞代谢反馈调控其功能。此外，巨噬细胞代谢可作为代谢性疾病治疗的理想靶点。因而，通过重组巨噬细胞

Basic－Mechanisms－of－SUMOylation

Like ubiquitin, SUMO (small ubiquitin-related modifier) proteins are small protein tags that are conjugated to proteins to modify their function. The

Basic－ELISA－Protocol

实验概要        There are many different types of ELISAs, which can detect the presence of protein in serum or supernatent. One of the most common typ

The－Effects－of－Ethanol－on－Zebrafish－Development

Introduction:The early stages of zebrafish, Danio rerio development are characterized by meroblastic dicoidal cleavage. Initially cell division only o

Effects－of－calcineurin－in－Keratinocyte－Differentiation

The differentiation of keratinocytes constantly replenishes the upper layers of human skin we lose each day. One factor that contributes to terminal k

The－Effects－of－Ultraviolet－Light－on－the－Fertilization

Jill K. Flemming, Franklin & Marshall College, Class of 2001IntroductionThe objective of this project is to observe the effects of UV radiation on bot

Developmental－Effects－of－Transplantation－of－Cell

From the various microsurgical procedures of Spemann and others, several developmental principles have emerged about amphibian embryos. One of the mos

Pelp1－Modulation－of－Estrogen－Receptor－Activity

Proline-,glutamic acid-,leucine-rich protein 1 (Pelp1 also known as:modulator of nongenomic activity of estrogen or MNAR) is a recently discovered tra

Determining－the－effects－of－nicotine－on－bone－－in－chicks

ObjectiveThe purpose of this experiment is to determine how the development of bone and cartilage in a chick are affected by treating the embryo with

The－Developmental－Effects－of－Nicotine－on－Chick－Embryos

More than 22 million American women smoke and approximately 25% of these women continue to smoke during pregnancy (Lambers and Clark 1996). Cigarette

Basic－Protein－Chemistry－Techniques

实验概要Basic Protein Chemistry Techniques实验步骤Coomassie Blue Stain:  (for gels) 1) Combine 225 ml Methanol with 225 ml ddH2O. 2) Add 0.5 grams of Coomassi

Basic－Methods－of－Culturing－Drosophila

实验概要Basic Methods of Culturing Drosophila实验步骤Stockkeeping1. Mechanics        Most stocks can be successfully cultured by periodic mass transfer of a

Basic－Protein－Chemistry－Techniques

Coomassie Blue Stain:  (for gels) 1) Combine 225 ml Methanol with 225 ml ddH2O. 2) Add 0.5 grams of Coomassie Blue. 3) Just before use, add 50 ml acet

PPARG的结构特点和生理作用

该基因编码核受体过氧化物酶体增殖激活受体（ppar）亚家族的一个成员。ppar与维甲酸x受体（rxrs）形成异二聚体，这些异二聚体调节各种基因的转录。已知三种ppar亚型：pparα、pparδ和pparγ。该基因编码的蛋白是pparγ，是脂肪细胞分化的调节因子。此外，pparγ还与许多疾病的病理学

核受体信号通路相关因子PPARG

该基因编码核受体过氧化物酶体增殖激活受体（ppar）亚家族的一个成员。ppar与维甲酸x受体（rxrs）形成异二聚体，这些异二聚体调节各种基因的转录。已知三种ppar亚型：pparα、pparδ和pparγ。该基因编码的蛋白是pparγ，是脂肪细胞分化的调节因子。此外，pparγ还与许多疾病的病理学

Biosynthesis－of－neurotransmitters

Neurotransmitters are signaling molecules used by neurons to communicate across chemical synapses. The receptors for neurotransmitters include G-prote

Regulation－of－PGC1a

Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nucl

Testing－the－effects－of－retinoic－acid－on－tail－formation

DEVELOPMENTAL－EFFECTS－OF－LITHIUM－CHLORIDE－ON－XENOPUS－EMBRYOS

PURPOSE: The objective of this experiment is to study the effect of lithium chloride treatment on early blastula xenopus embryos.INTRODUCTION: When th

The－Effects－of－NiCl2on－Spicule－Formation

The Effects of NiCl2on Spicule FormationJessica Ann Billet, Franklin and Marshall, Class of 2000Background and ObjectiveSea urchins exhibit radial hol

The－effects－ofdifferent－concentrations－oflithium－chloride－on－thedevelopment

AbstractPrevious studies by Stachel and colleagues indicate that lithium chloride induction of post-midblastular Brachydanio rerio embryos results in

筛分仪－AS－200－basic简介

德国RETSCH（莱驰）的AS200系列分析筛分仪广泛应用于科研与开发，原材料、半成品和成品的质量控制及生产监控等领域。其可控电磁驱动能为每一产品提供最优的配置。尖锐样品也能在短时间内过筛。AS200basic具有RETSCH 产品一贯的可靠性和质量保证。该机型采用模拟制式下的振幅和筛分时间设置。所