BasicmechanismofactionofPPARa,PPARb(d)andPPARgandeffects
Similar to other nuclear hormone receptores, PPAR acts as a ligand activated transcription factor. Upon binding fatty acids or hypolipidemic drugs, PPARa interacts with RXR and regulates the expression of target genes. These genes are involved in the catabolism of fatty acids. Conversely, PPARg is activated by prostaglandins, leukotrienes and anti-diabetic thiazolidinediones and affects the expression of genes involv......阅读全文
Basic－Method－for－Indirect－Immunofluorescence－Labeling
Basic Method for Indirect Immunofluorescence LabelingBackgroundThis is the method for indirect immunofluorescence labeling; that is, the antibodies do
Basic－Fluorescent－in－situ－Hybridization－(FISH)
实验概要Fluorescence in situ hybridization method is a kind of physical map drawing method, use fluorescent element mark probe, to detect probe and spli
Critical－Appraisal－of－the－MTT－Assay－in－the－Presence－of－Rottlerin－1
Rottlerin is a natural product isolated from Mallotus philippinensis. This polyphenolic compound, originally described as a selective inhibitor of PKC
Blockade－of－Neurotransmitter－Relase－by－Botulinum－Toxin
The neuromuscular junction communicates action potentials from motor neurons across a synapse to skeletal muscle. When an action impulse arrives at th
SUMOylation－as－a－mechanism－to－modulate－CtBPdependent－gene－responses
Covalent attachment of one eukaryotic protein to another is a prominent posttranslational modification and Ubiquitin is the most familiar of the prote
PPARG基因编码的功能和结构描述
该基因编码核受体过氧化物酶体增殖激活受体（ppar）亚家族的一个成员。ppar与维甲酸x受体（rxrs）形成异二聚体，这些异二聚体调节各种基因的转录。已知三种ppar亚型：pparα、pparδ和pparγ。该基因编码的蛋白是pparγ，是脂肪细胞分化的调节因子。此外，pparγ还与许多疾病的病理学
Basic－procedures－for－bacteria－culture2
E. Elution of DNA fragments from agaroseDNA fragments are eluted from low-melting temperature agarose gels using an unpublished procedure first develo
Basic－procedures－for－bacteria－culture1
A. Phenol extraction of DNA samplesPhenol extraction is a common technique used to purify a DNA sample (1). Typically, an equal volume of TE-saturated
核受体信号通路－PPARG基因的临床解释
该基因编码核受体过氧化物酶体增殖激活受体（ppar）亚家族的一个成员。ppar与维甲酸x受体（rxrs）形成异二聚体，这些异二聚体调节各种基因的转录。已知三种ppar亚型：pparα、pparδ和pparγ。该基因编码的蛋白是pparγ，是脂肪细胞分化的调节因子。此外，pparγ还与许多疾病的病理学
PPARG基因突变因子与药物介绍
该基因编码核受体过氧化物酶体增殖激活受体（ppar）亚家族的一个成员。ppar与维甲酸x受体（rxrs）形成异二聚体，这些异二聚体调节各种基因的转录。已知三种ppar亚型：pparα、pparδ和pparγ。该基因编码的蛋白是pparγ，是脂肪细胞分化的调节因子。此外，pparγ还与许多疾病的病理学
彭丽：非诺贝特治疗“糖网”，这类患者获益最大
引言：研究发现，非诺贝特对糖尿病视网膜病变的有益作用受PPARA基因多态性的影响，并由FGF-21水平增加而介导。rs6008845 T/T纯合子突变基因型糖尿病视网膜病变患者是非诺贝特治疗受益最大的人群。 非诺贝特是过氧化物酶体增殖物激活受体α（PPARA）的激动剂，多项试验表明，非诺贝特对
Realspace－and－realtime－dynamics－of－CRISPRCas9－visualized－by－...（一）
Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopyAbstractThe CRISPR-associated endonuclease Cas9 bind
Basic－Theory－and－Use－of－GCMS（二）
For ionisation to take place at all, chemical reaction between the sample and the reagent gas must be exothermic. The grater the heat of the reaction,
AvaSoftBasic标准版软件
AvaSoft-Basic标准版软件AvaSoft-Basic标准版软件是是随每套AvaSpec光谱仪系统免费赠送的标准软件包。AvaSoft-Basic软件界面友好，由鼠标指向控制下拉菜单。点击鼠标可以控制数据指针的移动，可以即时读取波长﹑像素值和 Y轴幅值。而按住鼠标左键或右键并拖曳可以方便并精
Basic－Theory－and－Use－of－GCMS（一）
BASIC THEORY AND USE OF GC-MSbyDr. Eugenia SobolevaContent1. Introduction.2. GC-MS systems and components.3. Vacuum system3.1. Rotary pump3.2. Di
筛分仪Sieve－Shaker－AS－450－basic简介
AS450 basic是强力振荡筛分仪AS450 control的基础版。 它用于干筛，筛分范围从 25 μm至125 mm，最大负载达15 kg。时间和振幅都是数字可调，可储存1组参数。对于需要大量样品干筛和湿筛的客户，AS450 basic是即经济又可靠的选择。应用实例化学制品, 土壤, 塑料,
异搏定和钆对青蛙骨骼肌纤维中咖啡因诱导的痉挛和钙...
异搏定和钆对青蛙骨骼肌纤维中咖啡因诱导的痉挛和钙离子流的影响许多研究证明咖啡因可以诱导骨骼肌的收缩，但Axelsson等科学家在青蛙的骨骼肌中注入咖啡因后却未发现收缩现象。面对这种现象，澳大利亚Tasmania大学的Lana Shabala等科学家推测咖啡因引起的青蛙慢骨骼肌纤维收缩的活性位点在胞外
How－to－use－Basic－Local－Alignment－Search－Tool－(BLAST)
DescriptionThe BLAST algorithm was developed as a way to perform DNA and protein sequence similarity searches by an algorithm that is faster than FAST
Basic－handson－course－in－thermal－analysis－software－(English)
METTLER TOLEDO is pleased to announce their series of one-day training courses, which are designed to familiarize users with thermal analysis theo
Critical－Appraisal－of－the－MTT－Assay－in－the－Presence－of－Rottlerin－6
Our experience indicates that it may not be sufficient to change the medium containing Rottlerin and to wash the cells before adding MTT to avoid a po
The－Effects－of－CalciumFree－Seawater－onthe－Development－ofSea－Urchin－Embryos
ObjectiveThe purpose of this experiment is to determine the effects of calcium-free seawater on the development of sea urchin embryos. Embryos were pl
Role－of－nicotinic－acetylcholine－receptors－in－the－regulation－of－apoptosis
Nicotinic acetylcholine receptors are essential for neuromuscular signaling and are also expressed in non-neuronal tissues, where their function is le
Metabolism－of－Anandamide,－an－Endogenous－Cannabinoid
The lipid anandamide derived from arachidonic acid binds to the cannabinoid G-protein coupled receptors CB-1 and CB-2 to exert its biological effects.
IMAGINGPAM相关文献集（二）
51. Krupenina NA, Bulychev AA. Action potential-induced changes in photosynthetic pattern of a plant cell Comparative Biochemistry and Phys
Opposing－roles－of－AIF－in－Apoptosis－and－Cell－Survival
Programmed cell death is induced by many different factors and involves numerous signaling pathways, some dependent on caspase proteases and others th
表界面科学最新文献KSV－NIMA
1. Name：Tuning structure and properties of ultra-low cross-linked temperature-sensitive microgels at interfaces via the adsorption pathwaysAuth
Thrombin－signaling－and－proteaseactivated－receptors
Thrombin is an extracellular protease that is involved in the clotting of blood and inflammation through its action on platelets and endothelial cells
IL10－Antiinflammatory－Signaling－Pathway
IL-10 is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by
Nature：靶向核受体分子－治疗贫血新策略
近日，来自美国麻省理工学院的研究人员在著名国际学术期刊nature在线发表了一项最新研究进展，他们发现PPARa激动剂对于治疗红细胞生成素抵抗性贫血症具有重要作用。 许多急性和慢性贫血症，包括红细胞溶解，脓毒病以及遗传性骨髓衰竭如Diamond-Blackfan贫血，对于红细胞生成素（Epo）
基本无菌化技术2
STERILIZATIONSterilization is the process that is intended to kill or remove all types of micro-organisms. There are two principal st erilization meth