NitrogendepedentregulationofRtg1andRtg3inTORpathway
Many key signaling molecules are conserved from yeast to man. mTOR is a protein kinase involved in nutrient and growth factor signaling in humans that has a yeast homolog with a similar role, TOR1. Like its human counterpart, yeast TOR1 is also inhibited by rapamycin. Signaling downstream of the TOR kinase pathways regulates the nuclear localization of several transcription factors in response to the carbon and nitro......阅读全文
Nitrogendepedent－regulation－of－Rtg1－and－Rtg3－in－TOR－pathway
Many key signaling molecules are conserved from yeast to man. mTOR is a protein kinase involved in nutrient and growth factor signaling in humans that
RHEB基因编码的功能和结构描述
该基因是小GTP酶超家族的成员，编码一种脂质锚定的细胞膜蛋白，具有5个重复的ras相关GTP结合区。由于这种蛋白在胰岛素/Tor/S6K信号通路中的作用，它在调节生长和细胞周期进程中是至关重要的。蛋白质具有GTP酶活性，在GDP结合形式和GTP结合形式之间穿梭，这种活性需要蛋白质的法呢酰化。已经绘制
RHEB基因突变因子与药物介绍
该基因是小GTP酶超家族的成员，编码一种脂质锚定的细胞膜蛋白，具有5个重复的ras相关GTP结合区。由于这种蛋白在胰岛素/Tor/S6K信号通路中的作用，它在调节生长和细胞周期进程中是至关重要的。蛋白质具有GTP酶活性，在GDP结合形式和GTP结合形式之间穿梭，这种活性需要蛋白质的法呢酰化。已经绘制
与肾癌相关的RHEB基因编码功能描述
该基因是小GTP酶超家族的成员，编码一种脂质锚定的细胞膜蛋白，具有5个重复的ras相关GTP结合区。由于这种蛋白在胰岛素/Tor/S6K信号通路中的作用，它在调节生长和细胞周期进程中是至关重要的。蛋白质具有GTP酶活性，在GDP结合形式和GTP结合形式之间穿梭，这种活性需要蛋白质的法呢酰化。已经绘制
mTOR－Signaling－Pathway
mTOR (mammalian target of rapamycin) appears to play a central role in signaling caused by nutrients and mitogens such as growth factors to regulate t
Regulation－of－BAD－phosphorylation
The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112,136 and 155). Phosphorylation at these sites re
Regulation－of－hematopoiesis－by－cytokines
The process of hematopoesis is regulated by various cytokines. The combination of cytokines stimulates the proliferation and/or differentiation of the
Regulation－of－Spermatogenesis－by－CREM
The transcriptional regulator CREM plays a key role in spermatogenesis, acting as a central transcription factor triggering a cascade of transcription
Complement－Pathway
The complement pathway consists of a series of over thirty proteins in plasma that are part of the immune response. Activation of the complement syste
Prion－Pathway
Transmissible spongiform encephalopathy (TSE) is thought to result from the structural conversion of cellular prion protein, PrP(C), into a misfolded
Dicer－Pathway
The degradation of endogenous mRNA in a sequence-specific manner can be induced by dsRNA [RNA interfernce (RNAi)], antisense transcription, or viral i
Antisense－Pathway
About 8% of human genes have been estimated to carry out transcription from both DNA strands, resulting in significant level of endogenous antisense R
Glycolysis－Pathway
Glycolysis was one of the first metabolic pathways studied and is one of the best understood, in terms of the enzymes involved, their mechanisms of ac
Fibrinolysis－Pathway
Clot formation and fibrinolysis is a balance of plasmin activation/inhibition and thrombin-thrombomodulin activity that regulates fibrin polymer forma
Regulation－of－eIF2
Protein phosphorylation plays an important role in the control of translation by eukaryotic initiation factor-2 (eIF-2). eIF-2 binds GTP and Met-tRNAi
CDK－Regulation－of－DNA－Replication
Initiation of DNA replication in eukaryotes is a highly conserved, multi-step process (replication licensing) designed to restrict initiation events t
Cyclins－and－Cell－Cycle－Regulation
The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted f
Stress－Induction－of－HSP－Regulation
Mammalian cells can respond to a variety of stresses such as heat, cold, oxidative stress, metabolic disturbance, and environmental toxins through nec
ChREBP－regulation－by－carbohydrates－and－cAMP
Although insulin and glucagon play important roles in regulating the response of cells to nutrients, cells also respond to carbohydrates through trans
Regulation－And－Function－Of－ChREBP－in－Liver
Liver is the major site for carbohydrate metabolism (glycolysis and glycogen synthesis) and triglyceride synthesis (lipogenesis). While insulin was lo
Regulation－of－PGC1a
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nucl
Regulation－of－transcriptional－activity－by－PML
The PML nuclear bodies are ring-shaped nuclear substructures associated with the regulation of transcription, transformation, cell growth, and apoptos
TOR：保持长寿和健康衰老的秘密所在
从酵母到猴子，只要没有营养不良，限制热量的饮食都已经被证明可以延长所有生命体的寿命和健康寿命。虽然没有长期研究证明限制卡路里对人类寿命的好处，但短期研究表明，它确实能改善健康。它可能是这样工作的。 我们的身体通过细胞中特定的分子来监测和感知营养物质的含量。根据我们吃的食物的数量，这些分子调节我
Role－of－Ran－in－mitotic－spindle－regulation
One of the central features of mitotic cell division is the formation of the spindle that segregates chromosomes into each daughter cell. Chromosomes
Sprouty－regulation－of－tyrosine－kinase－signals
Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors,
FXR－and－LXR－Regulation－of－Cholesterol－Metabolism
Cholesterol is essential for life and a key in the development of heart disease. Cholesterol homeostasis is achieved through regulation of cholesterol
WNT－Signaling－Pathway
Wnt family members are secreted glycoproteins who bind to cell surface receptors such as Frizzled. Wnt members can play a role in the expression of ma
TPO－Signaling－Pathway
Thrombopoietin (TPO) binds to its receptor inducing aggregation and activation. TPO signals its growth regulating effects to the cell through several
Insulin－Signaling－Pathway
The appropriate signaling through the insulin pathway is critical for the regulation of glucose levels and the avoidance of diabetes. Insulin forms a
Phosphatidylcholine－Biosynthesis－Pathway
The main components of biological membranes are phosphoglyceride lipids composed of a glycerol unit esterified to two fatty acids and a polar alcohol