IonChannelsandTheirFunctionalRoleinVascularEndothelium
Endothelial cells (EC) form a multifunctional signal-transducing surface that performs different tasks dependent on its localization in the vessel tree. Arterial EC provide a pathway for delivery of oxygen from blood to tissue. They modulate the tone of vascular smooth muscle cells, which in turn controls blood pressure and blood flow by adjusting the caliber of arteries and arterioles. In the microvascular bed, EC r......阅读全文
Role－of－nicotinic－acetylcholine－receptors－in－the－regulation－of－apoptosis
Nicotinic acetylcholine receptors are essential for neuromuscular signaling and are also expressed in non-neuronal tissues, where their function is le
Role－of－Erk5－in－Neuronal－Survival
Axons extend significant distances to innervate target tissues. At the site of innervation, target tissues release neurotrophins including NGF, BDNF a
Role－of－arrestins－in－the－activation－and－targeting－of－MAP－kinases
The binding of ?-arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kinase activation complex using ?-arrestin as a scaffold, with sub
Role－of－Parkin－in－the－UbiquitinProteasomal－Pathway
The motor defects of Parkinson's disease are related to the loss of dopaminergic neurons in specific brain regions. Examination of these neurons i
Role－of－Tob－in－Tcell－activation
Regulation of T cell activation is a crucial component of balanced functioning of the immune system. If the T cell response is too great and activatio
异搏定和钆对青蛙骨骼肌纤维中咖啡因诱导的痉挛和钙...
异搏定和钆对青蛙骨骼肌纤维中咖啡因诱导的痉挛和钙离子流的影响许多研究证明咖啡因可以诱导骨骼肌的收缩，但Axelsson等科学家在青蛙的骨骼肌中注入咖啡因后却未发现收缩现象。面对这种现象，澳大利亚Tasmania大学的Lana Shabala等科学家推测咖啡因引起的青蛙慢骨骼肌纤维收缩的活性位点在胞外
Physcomitrella－patens－:－A－NonVascular－Plant－for－Recombinant－Protein...
The moss Physcomitrella patens is a long-standing model for studying plant development, growth and cell differentiation in particular. Interest in
离子阱质谱仪（Ion－trap，IT）
在离子阱质谱仪中，可以捕获离子，因此也可以积累离子。离子阱技术具有无法比拟的高灵敏度和快速数据采集能力。将离子阱技术与数据依赖性采集技术（data-dependent acquisition）结合起来，我们就能进行高通量的质谱检测。不过，离子阱质谱仪的分辨率有限，捕获离子的能力不高，再加上空间电荷效
离子阱质谱仪（Ion－trap，IT）
A：离子产物扫描法（Production scanning）是蛋白质组学研究里最常用的MS/MS质谱检测策略。该方法的目的就是要获得蛋白质片段离子的质谱图，然后据此鉴定出蛋白质的氨基酸序列。在本试验中，第一个质谱仪MS1是用来筛选出某一特定的母离子。随后，被选出的母离子在碰撞池中经由碰撞诱导解离作用
Role－of－EGF－Receptor－Transactivation－by－GPCRs－in－Cardiac－Hypertrophy
One of responses to increased blood pressure is cardiac hypertrophy through increased size of ventricular myocardial cells leading to increased thickn
The－role－of－FYVEfinger－proteins－in－vesicle－transport
Eukaryotic cells take up constituents of the extra-cellular environment and regulate the cell-surface level of membrane proteins via a recycling syste
Role－of－ERBB2－in－Signal－Transduction－and－Oncology
Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with the
AKAP95－role－in－mitosis－and－chromosome－dynamics
The chromatin packaging of the genome is dynamic, changing with the cell cycle and with transcriptional regulation. During mitosis, chromatin is conde
Role－of－PPARgamma－Coactivators－in－Obesity－and－Thermogenesis
Nuclear hormone receptors are transcription factors that bind DNA and regulate transcription in a ligand-dependent manner. PPAR-gamma is a member of t
Role－of－MAL－in－RhoMediated－Activation－of－SRF
Serum response factor (SRF) is a transcription factor, which binds to a serum response element (SRE) associated with a variety of genes including (i)i
KCNJ3基因编码功能及结构描述
钾通道存在于大多数哺乳动物细胞中，它们参与了广泛的生理反应该基因编码的蛋白是一个完整的膜蛋白和内向整流型钾通道编码的蛋白质受g蛋白控制，在调节心跳中起着重要作用，这种蛋白质更倾向于让钾流入细胞而不是流出细胞。它与其他三个g蛋白激活的钾通道结合，形成一个异多聚成孔复合物，该复合物还与大脑中的神经递质受
什么是Liion电池？
Li-ion是锂电池发展而来。所以在介绍Li-ion之前，先介绍锂电池。举例来讲，以前照相机里用的扣式电池就属于锂电池。锂电池的正极材料是锂金属，负极是碳。当对电池进行充电时，电池的正极上有锂离子生成，生成的锂离子经过电解液运动到负极。而作为负极的碳呈层状结构，它有很多微孔，达到负极的锂离子就嵌
医学研究：电刺激可帮助控制大鼠出血（三）
Finite element computational modeling of the resistive heating during the maximum exposure (150 V, 100 μs/phase, 10 Hz, 30 s) demonstrated that the
Isolation－and－characterization－of－rat－glomerular－endothelial－cells
Glomerular endothelial cells (GECs) from the kidney are in close juxtaposition to other cell types, such as mesangial cells, and may respond to as
Nanodisc配合冷冻电镜提升膜蛋白的分辨率
Toxic, hot, and spicy: Nanodiscs improve membrane protein resolution in cryo-EM(作者：Cube Biotech) N
Role－of－MEF2D－in－Tcell－Apoptosis
Mef2 (Myocyte enhancer factor 2) transcription factors play a role in T-Cell Calcium Induced Apoptosis. Several factors regulate Mef2 transcription fa
、Liion电池有哪些优点？
a) 单体电池的工作电压高达3.6-3.8V： b) 比能量大，目前能达到的实际比能量为100-115Wh/kg和240-253Wh/L（2倍于Nl-Cd，1.5倍于Ni-MH）,未来随着技术发展,比能量可高达150Wh/kg和400 Wh/L c) 循环寿命长,一般均可达到500次以上,甚
Visual－Signal－Transduction
The signal transduction cascade responsible for sensing light in vertebrates is one of the best studied signal transduction processes, and is initiate
靶向骨骼内皮减少骨流失，促进骨愈合
骨质疏松是一种以单位体积内骨组织量减少为特点的代谢性骨病变，以骨形成（成骨）弱于骨吸收（破骨）作用所致。患者持续伴有骨骼疼痛、易骨折等特征，严重影响生活质量，而绝经后女性是骨质疏松的高危人群。甲状旁腺素（parathyroid hormone，PTH）类似物是临床上用于靶向成骨细胞（osteobla
液相超级光驱动器！我国院士Advanced－Functional－Materials发文
近日，中国科学院院士、中国科学院理化技术研究所研究员江雷与研究员王京霞，在Advanced Functional Materials上，发表了题为《Janus结构与溶剂/热/光协同促进的液相超级光驱动器》（Liquid-phase Super Photoactuator through the
Eph－Kinases－and－ephrins－support－platelet－aggregation
Eph kinases are a family of receptor tyrosine kinases with an extracellular domain that binds their ligand, the ephrins, and an intracellular kinase d
GentleMACS/单细胞悬液制备文献集锦
种属 处理组织 文章名称 human
哥伦比亚大学杨建教授访问上海药物所
8月12日，哥伦比亚大学杨建教授应李扬研究员邀请来上海药物研究所学术交流，并作了题为Ion Channels as Drug Targets and an Odd TRP to the Assembly of a Receptor/Ion Channel Complex的报告。
Gammaaminobutyric－Acid－Receptor－Life－Cycle
Gamma-amino butyric acid (GABA) is an inhibitory neurotransmitter that acts at synapses through binding to ligand-gated ion channels, the GABA recepto