WIKI资讯
WIKI资讯
PTEN is a tumor suppressor gene. Recombinant PTEN is capable of dephosphorylating phosphatidylinositol 3,4,5-triphosphate[PI(3,4,5)P3], the product of phosphatidylinositol 3 -kinase. Many of the cancer-related mutations have been mapped to the phosphatase catalytic domain, it has been suggested that the phosphatase activity of PTEN is required for its tumor suppressor function. The activation of PKB/AKT is regulated ......阅读全文
Cyclin-dependent kinase inhibitor-2A (CDKN2A) goes by the colloquial designation p16, which is sometimes referred to as p16(INK4). The alpha transcrip
The focus of this pathway is to illustrate the role of Polo-like Kinase 3 (Plk3 also known as Prk and Fnk) as part of the regulatory cascade leading t
BTG2 is found to be one of the immediate early genes up-regulated by neural growth factor (NGF) and epidermal growth factor (EGF). Its transcriptional
Hypoxic stress, like DNA damage, induces p53 protein accumulation and p53-dependent apoptosis in oncogenically transformed cells. Unlike DNA damage, h
CTCF is central to signaling pathways in immature B cells elicited by cross-linking the Ig BCR and stimulation with TGF?. Both stimuli result in induc
线粒体荧光探针信息大全 （Probes for Mitochondria）包括各种常用探针，如JC-1，JC-9，TMRM，TMRE等Mitochondria are found in eukaryotic cells, where they make up as much as 10% of th
Over 1,000 papers and reviews have been written about the role of ceramide in the production of programmed cell death or apoptosis. Ceramide is a sphi
The PML nuclear bodies are ring-shaped nuclear substructures associated with the regulation of transcription, transformation, cell growth, and apoptos
3. 实验过程 通过分子生物学克隆技术, 应用单克隆细胞技术的筛选，将荧光素酶的基因稳定整合到预期观察的细胞的染色体内，培养出能稳定表达荧光素酶蛋白的细胞株。典型的成像过程是：小鼠经过麻醉系统被麻醉后放入成像暗箱平台，软件控制平台的升降到一个合适的视野，自动开启照明灯拍摄第一次背景图。下一步，自动关
二、细胞实验效果不错，那动物实验怎么做？稳定性、重复性较好的动物模型可在肿瘤基础性研究和抗肿瘤药物筛选中发挥重要作用。血液肿瘤常用的动物模型主要有：I皮下移植瘤模型；II血液模型。皮下移植瘤模型较容易建立，易于动态观察肿瘤的生长状态。血液模型则一般以生存天数作为观察终点，用活体成像、病理切片、流式细
血液肿瘤主要包括各类白血病、多发性骨髓瘤以及恶性淋巴瘤。急性白血病占常见恶性肿瘤的第八位，淋巴瘤也是在前十位，并且发病率逐年升高，多发性骨髓瘤的整个发病率在血液恶性肿瘤里面占10%。 血液肿瘤发病急，在传统的放疗、化疗、骨髓移植等治疗方式下，治疗周期长、费用高昂、过程痛苦，但治愈率却并不很
引言：上海吉凯基因化学技术有限公司成立于2002年，拥有国内最大的慢病毒文库，同时也是国内最大的疾病关键基因科研服务供应商，在疾病研究领域的实验积累已逾14年！在这里，我们为大家特别整理了10多个研究领域的经验所得，将最实用的精华分享给大家！肺癌作为世界范围内第一大常见肿瘤，这次就当仁不让先来分享，
引言：上海吉凯基因化学技术有限公司成立于2002年，拥有国内最大的慢病毒文库，同时也是国内最大的疾病关键基因科研服务供应商，在疾病研究领域的实验积累已逾14年！在这里，我们为大家特别整理了10多个研究领域的经验所得，将最实用的精华分享给大家！肺癌作为世界范围内第一大常见肿瘤，这次就当仁不让先来分
The epidermis, which provides a protective barrier that undergoes a constant renewal, is a multi-layered tissue with the proliferating cells located i
Rottlerin is a natural product isolated from Mallotus philippinensis. This polyphenolic compound, originally described as a selective inhibitor o
ANALYSIS OF CELL CYCLE Miriam Capri and Daniela Barbieri Dept. Biomedical Sciences, Sect. General Pathology,Via Campi, 287, University of Mo
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutate
【摘要】 1型糖尿病（type1diabetes，T1DM）是一种自身免疫性疾病（Autoimmune disease），由于某些遗传因素与环境因素的共同作用，引发了胰岛β细胞为主体的慢性自身免疫损害反应，β细胞可被细胞毒性T细胞、细胞因子或NO损伤，导致一种缓慢发生的、累积性加重的胰岛
TroubleshootingCritical Steps(1) Don’t trypsinize cells for too long when collecting them.(2) Rotation speed should be no more than 1500 rpm during ce
Objective: This experiment aims to discover if temperature has an effect on the rates of sea urchin embryonic development. By altering the extern
Cell cycle checkpoint controls at the G1 to S transition and the G2 to M transition prevent the cell cycle from progressing when DNA is damaged. The A
Chemical Induction of Apoptosis - 1 May 2001p53, p21WAF1, Myc, Bcl-2, Bax, Bcl-x and bak are among the proteins involved in the regulation of apoptosi
实验概要Apoptosis is a carefully regulated process of cell death that occurs as a normal part of development. Inappropriately regulated apopto
Chapter 1: Cell Death - Apoptosis and Necrosis1.1Introduction21.1.1Terminology of cell death21.1.2Differences between necrosis and apoptosis31.1.3Apop
Programmed cell death is induced by many different factors and involves numerous signaling pathways, some dependent on caspase proteases and others th
IntroductionFetal Alcohol Syndrome (FAS) is caused by exposure of the developing embryo to alcohol, one of several teratogenic agents which adversely
实验概要Live cell studies of cellular DNA content and cell cycle distribution are useful to detect variations of growth patterns due to a vari
实验概要Live cell studies of cellular DNA content and cell cycle distribution are useful to detect variations of growth patterns due to a vari
ASTRACTWe describe a rapid and quantitative flow cytometric method for determining the apoptotic or anti-apoptotic potential of a gene in various cell
IntroductionApoptosis is a normal physiological phenomenon put forward by Kerr [1]. It plays an important role in embryonic development, maintenance o